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Protein
Submitted name:

Transmembrane protein 131-like

Gene

TMEM131L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane protein 131-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM131LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121210.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29146 TMEM131L

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000121210

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H0Y2M0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H0Y2M0

PRoteomics IDEntifications database

More...
PRIDEi
H0Y2M0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121210 Expressed in 188 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0Y2M0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
H0Y2M0, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
H0Y2M0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3620 Eukaryota
ENOG410Z7NH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063614

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039877 TMEM131-like

The PANTHER Classification System

More...
PANTHERi
PTHR22050 PTHR22050, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0Y2M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PVPCRVIPAM GKTSFRIIFL PTEEGSIESS LFINTSSYGV LSYHVSGIGT
60 70 80 90 100
RRISTEGSAK QLPNAYFLLP KVQSIQLSQM QAETTNTSLL QVQLECSLHN
110 120 130 140 150
KVCQQLKGCY LESDDVLRLQ MSIMVTMENF SKEFEENTQH LLDHLSIVYV
160 170 180 190 200
ATDESETSDD SAVNMYILHS GNSLIWIQDI RHFSQRDALS LQFEPVLLPT
210 220 230 240 250
STTNFTKIAS FTCKAATSCD SGIIEDVKKT THTPTLKACL FSSVAQGYFR
260 270 280 290 300
MDSSATQFHI ETHENTSGLW SIWYRNHFDR SVVLNDVFLS KETKHMLKIL
310 320 330 340 350
NFTGPLFLPP GCWNIFSLKL AVKDIAINLF TNVFLTTNIG AIFAIPLQIY
360 370 380 390 400
SAPTKEGSLG FEVIAHCGMH YFMGKSKAGN PNWNGSLSLD QSTWNVDSEL
410 420 430 440 450
ANKLYERWKK YKNGDVCKFG TDMQMINFTT GEFQLTEACP YLGTHSEESR
460 470 480 490 500
FGILHLHLQP LEMKRVGVVF TPADYGKVTS LILIRNNLTV IDMIGVEGFG
510 520 530 540 550
ARELLKVGGR LPGAGGSLRF KVPESTLMDC RRQLKDSKQI LSITKNFKVE
560 570 580 590 600
NIGPLPITVS SLKINGYNCQ GYGFEVLDCH QFSLDPNTSR DISIVFTPDF
610 620 630 640 650
TSSWVIRDLS LVTAADLEFR FTLNVTLPHH LLPLCADVVP GPSWEESFWR
660 670 680 690 700
LTVFFVSLSL LGVILIAFQQ AQYILMEFMK TRQRQNASSS SQQNNGPMDV
710 720 730 740 750
ISPHSYKSNC KNFLDTYGPS DKGRGKNCLP VNTPQSRIQN AAKRSPATYG
760 770 780 790 800
HSQKKHKCSV YYSKHKTSTA AASSTSTTTE EKQTSPLGSS LPAAKEDICT
810 820 830 840 850
DAMRENWISL RYASGINVNL QKNLTLPKNL LNKEENTLKN TIVFSNPSSE
860 870 880 890 900
CSMKEGIQTC MFPKETDIKT SENTAEFKER ELCPLKTSKK LPENHLPRNS
910 920 930 940 950
PQYHQPDLPE ISRKNNGNNQ QVPVKNEVDH CENLKKVDTK PSSEKKIHKT
960 970 980 990 1000
SREDMFSEKQ DIPFVEQEDP YRKKKLQEKR EGNLQNLNWS KSRTCRKNKK
1010 1020 1030 1040 1050
RGVAPVSRPP EQSDLKLVCS DFERSELSSD INVRSWCIQE STREVCKADA
1060 1070 1080 1090 1100
EIASSLPAAQ REAEGYYQKP EKKCVDKFCS DSSSDCGSSS GSVRASRGSW
1110 1120 1130 1140 1150
GSWSSTSSSD GDKKPMVDAQ HFLPAGDSVS QNDFPSEAPI SLNLSHNICN
1160 1170 1180 1190 1200
PMTVNSLPQY AEPSCPSLPA GPTGVEEDKG LYSPGDLWPT PPVCVTSSLN
1210 1220 1230 1240 1250
CTLENGVPCV IQESAPVHNS FIDWSATCEG QFSSAYCPLE LNDYNAFPEE
1260 1270 1280 1290 1300
NMNYANGFPC PADVQTDFID HNSQSTWNTP PNMPAAWGHA SFISSPPYLT
1310 1320 1330 1340 1350
STRSLSPMSG LFGSIWAPQS DVYENCCPIN PTTEHSTHME NQAVVCKEYY
1360 1370 1380
PGFNPFRAYM NLDIWTTTAN RNANFPLSRD SSYCGNV
Length:1,387
Mass (Da):154,748
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67F9B45B1AFA405E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2VDJ0T131L_HUMAN
Transmembrane protein 131-like
TMEM131L KIAA0922
1,609Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEQ2F8WEQ2_HUMAN
Transmembrane protein 131-like
TMEM131L
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000240487; ENSP00000240487; ENSG00000121210

UCSC genome browser

More...
UCSCi
uc063aib.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y2M0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiH0Y2M0, 2 interactors

Proteomic databases

jPOSTiH0Y2M0
MaxQBiH0Y2M0
PRIDEiH0Y2M0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240487; ENSP00000240487; ENSG00000121210
UCSCiuc063aib.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000121210.15
HGNCiHGNC:29146 TMEM131L
OpenTargetsiENSG00000121210

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3620 Eukaryota
ENOG410Z7NH LUCA
GeneTreeiENSGT00530000063614

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA0922 human

Gene expression databases

BgeeiENSG00000121210 Expressed in 188 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiH0Y2M0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR039877 TMEM131-like
PANTHERiPTHR22050 PTHR22050, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y2M0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y2M0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: January 16, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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