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Protein
Submitted name:

Leucine rich repeat containing 8 VRAC subunit B

Gene

LRRC8B

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine rich repeat containing 8 VRAC subunit BImported
Gene namesi
Name:LRRC8BImported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei316 – 338HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000021794

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 334Pannexin_likeInterPro annotationAdd BLAST334

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148937
InParanoidiH0Y0A1
OMAiNSQDKVE
OrthoDBiEOG091G01ER
TreeFamiTF331443

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR038960 LRRC8
IPR021040 LRRC8_Pannexin-like
PANTHERiPTHR43945 PTHR43945, 1 hit
PfamiView protein in Pfam
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 1 hit
PF12534 Pannexin_like, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

H0Y0A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITLTELKCL ADTQASYHIL KPWWDVFWYY ITLIMLLVAV LAGALQLTQS
60 70 80 90 100
RVLCCLPCKV EFDNHCAVPW DILKASANAS SNPETPFPLP LRIQNDLHRQ
110 120 130 140 150
QYSYIDAVCY EKQLHWFAKF FPYLVLLHTL IFAACSNFWL HYPSTSSRLE
160 170 180 190 200
HFVAILHKCF DSPWTTRALS ETVAEQSVRP MKLSKSKILL SSSGCSADVD
210 220 230 240 250
SSKQSLPYPQ PGLESAGIES PTSSVLDKKE GEQAKAIFEK VKRFRMHVEQ
260 270 280 290 300
KDIIYRVYLK QIIVKVILFA LIITYVPYFL TYISLEIDCS IDVQAFTGYK
310 320 330 340 350
HYQCVYSLAE IFKVLASFYV ILVILYGLTS SYSLWWMLRS SLKQYSFEAL
360 370 380 390 400
REKSNYSDIP DVKNDFAFIL HLADQYDPLY SKRFSIFLSE VSENKLKQIN
410 420 430 440 450
LNNEWTVEKL KSKLVKNAQD KIELHLFMLN GLPDNVFELT EMEVLSLELI
460 470 480 490 500
PEVKLPSAVS QLVNLKELRV YHSSLVVDHP ALAFLEENLK ILRLKFTEMG
510 520 530 540 550
KIPRWVFHLK NLKELYLSGC VLPEQLGTMQ LEGFQDLKNL RTLYLKSSLS
560 570 580 590 600
RIPQVVTDLL PSLQKLSLDN EGSKLVVLNN LKKMVNLKSL ELISCDLERI
610 620 630 640 650
PHSIFSLNNL HELDLKENNL KTVEEIISFQ HLQNLSCLKL WHNNIAYIPA
660 670 680 690 700
QIGALSNLEQ LSLDHNNIEN LPLQLFLCTK LHYLDLSYNH LTFIPEEIQY
710 720 730 740 750
LSNLQYFAVT NNNIEVLPDG LFQCKKLQCL LLGKNSLMNL SPLVGELLNL
760 770 780 790 800
TYLELVGNYL ETLPPELEGC QSLKRSCLIV EENLLNTLPN PVTERLQTCL

DKC
Length:803
Mass (Da):92,331
Last modified:February 22, 2012 - v1
Checksum:i0BD4B2E7DC3B024F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03023082 Genomic DNA No translation available.
AAQR03023083 Genomic DNA No translation available.
RefSeqiXP_012657121.1, XM_012801667.1

Genome annotation databases

EnsembliENSOGAT00000030924; ENSOGAP00000021794; ENSOGAG00000032246
GeneIDi100947733

Similar proteinsi

Entry informationi

Entry nameiH0Y0A1_OTOGA
AccessioniPrimary (citable) accession number: H0Y0A1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 20, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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