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Protein

Galactose-1-phosphate uridylyltransferase

Gene

GALT

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.PROSITE-ProRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184ZincPROSITE-ProRule annotation1
Active sitei186Tele-UMP-histidine intermediateUniRule annotation1
Metal bindingi202IronUniRule annotation1
Metal bindingi301IronUniRule annotation1
Metal bindingi319IronUniRule annotation1
Metal bindingi321IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processCarbohydrate metabolism, Galactose metabolismUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferaseUniRule annotation (EC:2.7.7.12UniRule annotation)
Gene namesi
Name:GALTImported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000021522

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 196GalP_UDP_transfInterPro annotationAdd BLAST173
Domaini203 – 367GalP_UDP_tr_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2958 Eukaryota
COG1085 LUCA
GeneTreeiENSGT00390000016188
InParanoidiH0XZH9
OMAiHAIYYPP
OrthoDBiEOG091G0ER8
TreeFamiTF300018

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit

Sequencei

Sequence statusi: Complete.

H0XZH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCSGADLDR RQQASEADIP VAAFQASDHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPHYD ATFLFDNDFP
110 120 130 140 150
ALQPDAPSPG PSDHPLFQAE AARGVCKVMC FHPWSDMTLP LMSVPEIRAV
160 170 180 190 200
VDAWASVTEE LGVQYPWVQI FENKGSMMGC SNPHPHCQVW ASSFLPDIAQ
210 220 230 240 250
REERSQRAYQ SQHGVPLLME YSRQELIKKE RLVLTSEHWL VLVPFWAVWP
260 270 280 290 300
YQTLLLPRRH VRRLPELTSA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGSAAG DNWDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRA LPEVHYCLRQ KDRETAAIA
Length:379
Mass (Da):43,344
Last modified:February 22, 2012 - v1
Checksum:i4D576BDF526A7DEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03161459 Genomic DNA No translation available.
RefSeqiXP_003800307.1, XM_003800259.2

Genome annotation databases

EnsembliENSOGAT00000035040; ENSOGAP00000021522; ENSOGAG00000025118
GeneIDi100954354

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03161459 Genomic DNA No translation available.
RefSeqiXP_003800307.1, XM_003800259.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000021522

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOGAT00000035040; ENSOGAP00000021522; ENSOGAG00000025118
GeneIDi100954354

Organism-specific databases

CTDi2592

Phylogenomic databases

eggNOGiKOG2958 Eukaryota
COG1085 LUCA
GeneTreeiENSGT00390000016188
InParanoidiH0XZH9
OMAiHAIYYPP
OrthoDBiEOG091G0ER8
TreeFamiTF300018

Enzyme and pathway databases

UniPathwayi
UPA00214

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0XZH9_OTOGA
AccessioniPrimary (citable) accession number: H0XZH9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 10, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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