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Protein

Glucosylceramidase

Gene

GBA

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
Biological processLipid metabolism, Sphingolipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
Gene namesi
Name:GBAImported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_500354651340 – 537GlucosylceramidaseSequence analysisAdd BLAST498

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000021360

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 466Glyco_hydro_30InterPro annotationAdd BLAST350
Domaini469 – 532Glyco_hydro_30CInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2566 Eukaryota
COG5520 LUCA
GeneTreeiENSGT00390000009464
InParanoidiH0XZ17
OMAiTYCDSLD
OrthoDBiEOG091G06I4
TreeFamiTF314254

Family and domain databases

Gene3Di2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR033452 GH30_C
IPR001139 Glyco_hydro_30
IPR033453 Glyco_hydro_30_TIM-barrel
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11069 PTHR11069, 1 hit
PfamiView protein in Pfam
PF02055 Glyco_hydro_30, 1 hit
PF17189 Glyco_hydro_30C, 1 hit
PRINTSiPR00843 GLHYDRLASE30
SUPFAMiSSF51445 SSF51445, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

H0XZ17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFSSPSREE CPKHLGREGV MAASFTALLL LQAVSWASGA RPCIPKSFGY
60 70 80 90 100
SSVVCVCNAT YCDSLDPLTL PAPGTFSRYE STRSGRRMEL STGTIEANHT
110 120 130 140 150
GTGLLLTLQP EQRFQKMKGF GGAMTDAAAL NILALSPPAQ DLLLKSYFSE
160 170 180 190 200
EGIEYNIIRV PMASCDFSIR IYTYADTPDD FQLHNFSLPE EDTKLKIPLI
210 220 230 240 250
HRALKLSQRH VSLFASPWTS PTWLKTNGAV NGKGSLKGQP GDIYHQSWAK
260 270 280 290 300
YFVKFLDAYA EQKLQFWAVT AENEPSAGLM SGYPFQCLGF TPEHQRDFIA
310 320 330 340 350
RDLGPTLANS THRNVHLLML DDNRLLLPHW AQVVLKDPEA AKYVHGIAVH
360 370 380 390 400
WYLDFLAPAE ATLGETHRLF PNTMLFASEA CVGSKFWEQS VRLGSWDRGM
410 420 430 440 450
QYSHSIITNL LYHVVGWTDW NLALNPEGGP NWVRNFVDSP IIVDINKDTF
460 470 480 490 500
YKQPMFYHLG HFSKFIPEGS QRVGLVASEK SHLDTVALIH PDGSAAVAVV
510 520 530
LNRSSKDVPL TIKDPALGFL KTISPGYSIQ TYLWRRQ
Length:537
Mass (Da):59,967
Last modified:February 22, 2012 - v1
Checksum:iD4BAA0D47DE98A4F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0XMQ0H0XMQ0_OTOGA
Glucosylceramidase
GBA
331Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03119144 Genomic DNA No translation available.
AAQR03119145 Genomic DNA No translation available.
RefSeqiXP_012664043.1, XM_012808589.1

Genome annotation databases

EnsembliENSOGAT00000030916; ENSOGAP00000021360; ENSOGAG00000031511
GeneIDi100957640

Similar proteinsi

Entry informationi

Entry nameiH0XZ17_OTOGA
AccessioniPrimary (citable) accession number: H0XZ17
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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