Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 56 (29 Sep 2021)
Sequence version 1 (22 Feb 2012)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

SP140 nuclear body protein

Gene

SP140

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SP140 nuclear body proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SP140Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri30611 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
30611.ENSOGAP00000020888

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 119HSRInterPro annotationAdd BLAST117
Domaini534 – 616SANDInterPro annotationAdd BLAST83
Domaini646 – 692PHD-typeInterPro annotationAdd BLAST47
Domaini751 – 785BromoInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 154DisorderedSequence analysisAdd BLAST21
Regioni238 – 340DisorderedSequence analysisAdd BLAST103
Regioni372 – 408DisorderedSequence analysisAdd BLAST37
Regioni423 – 488DisorderedSequence analysisAdd BLAST66
Regioni501 – 529DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi279 – 296Polar residuesSequence analysisAdd BLAST18
Compositional biasi381 – 398Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi432 – 449Polar residuesSequence analysisAdd BLAST18
Compositional biasi450 – 470Basic residuesSequence analysisAdd BLAST21
Compositional biasi501 – 528Basic residuesSequence analysisAdd BLAST28

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162129

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015844_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0XXP5

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGNSDEC

TreeFam database of animal gene trees

More...
TreeFami
TF335091

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.10.390.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR004865, HSR_dom
IPR010919, SAND-like_dom_sf
IPR000770, SAND_dom
IPR043563, Sp110/Sp140/Sp140L
IPR030411, Sp140
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR46386, PTHR46386, 2 hits
PTHR46386:SF6, PTHR46386:SF6, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 1 hit
PF03172, HSR, 1 hit
PF01342, SAND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00249, PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit
SSF63763, SSF63763, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51414, HSR, 1 hit
PS50864, SAND, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H0XXP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RMDTDSQNTD NKDLDELIFP QLLLKHFREN KVEIATAITQ PFPFLMSLRD
60 70 80 90 100
RAFISQTMFE NFQEACRNLI PVPRVMYDVL SELERTFDPS LLETLFSKVN
110 120 130 140 150
LKAYPDLNEI FRSFQKVWDA LICEHHTLNL KRENDDEEEP HIHSFQDRRD
160 170 180 190 200
SNAYPEMHDV EEPQEALRSP PRCGPGKEGC HFLVSLWFPG RDARETLKLL
210 220 230 240 250
PGGGGCWKLT PQTDGEESEE IPRLLPYDRE GRFQINGRVD QSMSYQEATG
260 270 280 290 300
MWEGEKRGRN RPVKRNKSRP KVPREADRQQ AQKSCNTATP QMTNEELDKV
310 320 330 340 350
LSLLPSEGEE GGNTCLEMCD GKEPQEASSP PPTCGPENRC LTAEDGFARQ
360 370 380 390 400
MTNEEEPEEV PRQLVLEGEV SGELEDQQTD EEGGSDQHTS RLPCDDEPGA
410 420 430 440 450
EQPEDGNGKC SCVMCFTKDV PEDPEARTAT GQPRGSRDTV ITGNNSTLGQ
460 470 480 490 500
PRRKRRRKKG HSWSRIKRRR YKPIQQNEND KADGQLVSSK NNMTHQPLAK
510 520 530 540 550
LKVRKRRRRR KCFTRRDRAP RKRGRARASR IPRDPTMDFQ APLLTVTCGE
560 570 580 590 600
AKGTLHKKKL KQGYQLYKCL HCEDGRNLSP IAVKVKWEKS LQRKNSMTTR
610 620 630 640 650
TVAEAVLWIF QGGMLPHPSR VYNGRKKRRI LKSHDTNSDD PSLGNMDECE
660 670 680 690 700
VCRDGGFLYC CDTCSRAFHE DCHIPPVEIE QNPWSCIFCS MKEFPEDQQC
710 720 730 740 750
YQEFEILEKQ MGPEEQLKCE FLLLKVYCCS ESSFFAKIPY YYYLGEACQG
760 770 780 790 800
LKEPMWLNKI KKKLHEKGYP RVEGFVQDMR LIFQNHRASY KYNNFGQMGF
810 820
RLEAEFEKNF KEMFAIQEKD ENS
Length:823
Mass (Da):95,194
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i102A3E5D30ED3B7A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAQR03030278 Genomic DNA No translation available.
AAQR03030279 Genomic DNA No translation available.
AAQR03030280 Genomic DNA No translation available.
AAQR03030281 Genomic DNA No translation available.
AAQR03030282 Genomic DNA No translation available.
AAQR03030283 Genomic DNA No translation available.
AAQR03030284 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOGAT00000029723; ENSOGAP00000020888; ENSOGAG00000030726

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03030278 Genomic DNA No translation available.
AAQR03030279 Genomic DNA No translation available.
AAQR03030280 Genomic DNA No translation available.
AAQR03030281 Genomic DNA No translation available.
AAQR03030282 Genomic DNA No translation available.
AAQR03030283 Genomic DNA No translation available.
AAQR03030284 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000020888

Genome annotation databases

EnsembliENSOGAT00000029723; ENSOGAP00000020888; ENSOGAG00000030726

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000162129
HOGENOMiCLU_015844_1_0_1
InParanoidiH0XXP5
OMAiLGNSDEC
TreeFamiTF335091

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.10.390.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR004865, HSR_dom
IPR010919, SAND-like_dom_sf
IPR000770, SAND_dom
IPR043563, Sp110/Sp140/Sp140L
IPR030411, Sp140
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR46386, PTHR46386, 2 hits
PTHR46386:SF6, PTHR46386:SF6, 2 hits
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF03172, HSR, 1 hit
PF01342, SAND, 1 hit
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00249, PHD, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit
SSF63763, SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51414, HSR, 1 hit
PS50864, SAND, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0XXP5_OTOGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0XXP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 29, 2021
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again