Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

FDXR

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51FAD; via amide nitrogenUniRule annotation1
Binding sitei72FADUniRule annotation1
Binding sitei80FAD; via amide nitrogenUniRule annotation1
Binding sitei116FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei243NADPUniRule annotation1
Binding sitei401FAD; via amide nitrogenUniRule annotation1
Binding sitei408NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 190NADPUniRule annotation4
Nucleotide bindingi231 – 232NADPUniRule annotation2
Nucleotide bindingi408 – 410FADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrialUniRule annotation (EC:1.18.1.6UniRule annotation)
Gene namesi
Name:FDXRImported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000015105

Structurei

3D structure databases

ProteinModelPortaliH0XGA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 198FAD/NAD-binding_domInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1800 Eukaryota
COG0493 LUCA
GeneTreeiENSGT00390000013574
InParanoidiH0XGA9
OMAiWGLRFFR
OrthoDBiEOG091G0EIW
TreeFamiTF314193

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Complete.

H0XGA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRCWFWWR WSAWPRTRPP FAGSTPTPGL LQQFSTQEKT PQICVVGSGP
60 70 80 90 100
AGFYTAQHLL KHHPQAQVDI YEKQFVPFGL VRFGVAPDHP EVKNVINTFT
110 120 130 140 150
QTAHSDRCAF WGNVEVGRDV TVPELQEAYH AVVLSYGAED HQPLGIPGEE
160 170 180 190 200
LPGVLSARTF VGWYNGLPEN RELTPDLSCD TVVILGQGNV ALDVARILLT
210 220 230 240 250
PPEHLERTDI TKAALEVLRQ SQVKTVWIVG RRGPLQVAFT IKELREMIQL
260 270 280 290 300
PGTRPILDSE NFLGLQDRIK EVPRPRKRLT ELLLQTATQK PSGEETAHQA
310 320 330 340 350
LASRVWGLRF FRSPQQVLPS PDGRRVAGIR LAVTRLEGVG EATRAVPTGD
360 370 380 390 400
TEDLPCGLVL SSVGYKSRPI DPSVPFDPKL GVIPNTEGRV VDVPGLYCSG
410 420 430 440 450
WVKRGPTGVI ATTMSDSFLT GQTLLQDLKA GLLPSGPRPG SVAIQTLLRS
460 470 480 490
RGVRPVSFSD WEKLDAEEVA RGQGAGKPRE KLVDPREMLQ LLGH
Length:494
Mass (Da):54,443
Last modified:February 22, 2012 - v1
Checksum:i6D0E563BF42F8DAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03041617 Genomic DNA No translation available.
AAQR03041618 Genomic DNA No translation available.
RefSeqiXP_003786199.1, XM_003786151.2

Genome annotation databases

EnsembliENSOGAT00000016873; ENSOGAP00000015105; ENSOGAG00000016869
GeneIDi100954175

Similar proteinsi

Entry informationi

Entry nameiH0XGA9_OTOGA
AccessioniPrimary (citable) accession number: H0XGA9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: May 23, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health