UniProtKB - H0XBH5 (H0XBH5_OTOGA)
Protein
IRF tryptophan pentad repeat domain-containing protein
Gene
IRF4
Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- positive regulation of interleukin-10 production Source: Ensembl
- positive regulation of interleukin-13 production Source: Ensembl
- positive regulation of interleukin-2 production Source: Ensembl
- positive regulation of interleukin-4 production Source: Ensembl
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: IRF tryptophan pentad repeat domain-containing proteinInterPro annotation |
Gene namesi | Name:IRF4Imported |
Organismi | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported |
Taxonomic identifieri | 30611 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Strepsirrhini › Lorisiformes › Galagidae › Otolemur |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 129 | IRF tryptophan pentad repeatInterPro annotationAdd BLAST | 109 |
Phylogenomic databases
eggNOGi | ENOG502QUE4, Eukaryota |
GeneTreei | ENSGT00940000159059 |
HOGENOMi | CLU_031544_1_1_1 |
InParanoidi | H0XBH5 |
OMAi | EQPHPEI |
TreeFami | TF328512 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H0XBH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLEGGGRGG EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF
60 70 80 90 100
RIPWKHAGKQ DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA
110 120 130 140 150
LNKSNDFEEL VERSQLDISD PYKVYRIVPE GAKKGAKQLT LEDPQMTMNH
160 170 180 190 200
PYTMAAPYTP LPAQQVHNYV MPPLDRSWRD YVPDQPHPEI PYQCPMPFGP
210 220 230 240 250
RSHHWQGPAC ENANAGCQVT GTFYACAPPE SQAPGIPTEP SIRSAEALAL
260 270 280 290 300
SDCRLHICLY YREILVKELT TSSPEGCRIS HGHTYDASNL DQVLFPYPED
310 320 330 340 350
NGQRKNIEKL LSHLERGVVL WMAPDGLYAK RLCQSRIYWD GPLALCSDRP
360 370 380 390 400
NKLERDQTCK LFDTQQFLSE LQAFAHHSRP LPRFQVTLCF GEEFPDPQRQ
410 420 430 440 450
RKLITAHVEP LLARQLYYFA QQNSGHFLRG YDMSEHISSP EDYHRSIRHS
SIQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAQR03152356 Genomic DNA No translation available. AAQR03152357 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSOGAT00000014578; ENSOGAP00000013057; ENSOGAG00000014574 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAQR03152356 Genomic DNA No translation available. AAQR03152357 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 30611.ENSOGAP00000013057 |
Genome annotation databases
Ensembli | ENSOGAT00000014578; ENSOGAP00000013057; ENSOGAG00000014574 |
Phylogenomic databases
eggNOGi | ENOG502QUE4, Eukaryota |
GeneTreei | ENSGT00940000159059 |
HOGENOMi | CLU_031544_1_1_1 |
InParanoidi | H0XBH5 |
OMAi | EQPHPEI |
TreeFami | TF328512 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0XBH5_OTOGA | |
Accessioni | H0XBH5Primary (citable) accession number: H0XBH5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | October 7, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |