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Entry version 49 (07 Oct 2020)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Arginine-glutamic acid dipeptide repeats

Gene

RERE

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Arginine-glutamic acid dipeptide repeatsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REREImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri30611 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

AcetylationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
30611.ENSOGAP00000011069

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 283BAHInterPro annotationAdd BLAST181
Domaini284 – 387ELM2InterPro annotationAdd BLAST104
Domaini391 – 443SANTInterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 90DisorderedSequence analysisAdd BLAST90
Regioni464 – 495DisorderedSequence analysisAdd BLAST32
Regioni542 – 1124DisorderedSequence analysisAdd BLAST583
Regioni1152 – 1237DisorderedSequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 38PolyampholyteSequence analysisAdd BLAST38
Compositional biasi50 – 75PolyampholyteSequence analysisAdd BLAST26
Compositional biasi464 – 486PolarSequence analysisAdd BLAST23
Compositional biasi556 – 571PolyampholyteSequence analysisAdd BLAST16
Compositional biasi605 – 626PolarSequence analysisAdd BLAST22
Compositional biasi627 – 670PolyampholyteSequence analysisAdd BLAST44
Compositional biasi671 – 687PolarSequence analysisAdd BLAST17
Compositional biasi688 – 707PolyampholyteSequence analysisAdd BLAST20
Compositional biasi708 – 748PolarSequence analysisAdd BLAST41
Compositional biasi773 – 788Pro-richSequence analysisAdd BLAST16
Compositional biasi887 – 902PolarSequence analysisAdd BLAST16
Compositional biasi903 – 939Pro-richSequence analysisAdd BLAST37
Compositional biasi970 – 1055Pro-richSequence analysisAdd BLAST86
Compositional biasi1152 – 1200PolyampholyteSequence analysisAdd BLAST49

Keywords - Domaini

Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2133, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005292_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0X6R3

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCRRLNS

TreeFam database of animal gene trees

More...
TreeFami
TF328554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202, ZnF_GATA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002951, Atrophin-like
IPR001025, BAH_dom
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03154, Atrophin-1, 1 hit
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H0X6R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENSRPRRS CTLEGGAKNY
60 70 80 90 100
AESDHSEDED NDNNSATTEE STKKNKKKPP KKKSRYERTD TGEITSYITE
110 120 130 140 150
DDVIYRPGDC VYIESRRPNT PYFICSIQDF KLVHTSQACC RSPTPALCDP
160 170 180 190 200
PACSLPVASQ PPQHLSEAGR GPVGSKRDHL LMNVKWYYRQ SEVPDSVYQH
210 220 230 240 250
LVQDRHNEND SGRELVITDP VIKNRELFIS DYVDTYHAAA LRGKCNISHF
260 270 280 290 300
SDIFAAREFK ARVDSFFYIL GYNPETRRLN STQGEIRVGP SHQAKLPDLQ
310 320 330 340 350
PFPSPDGDTV TQHEELVWMP GVNDCDLLMY LRAARSMAAF AGMCDGGSTE
360 370 380 390 400
DGCVAASRDD TTLNALNTLH ESGYDAGKAL QRLVKKPVPK LIEKCWTEDE
410 420 430 440 450
VKRFVKGLRQ YGKNFFRIRK ELLPNKETGE LITFYYYWKK TPEAASSRAH
460 470 480 490 500
RRHRRQAVFR RIKTRTASTP VSTPSRPPSS EFLDLSSASE DDFDSEDSEQ
510 520 530 540 550
ELKGYACRHC FTTTSKDWHH GGRENILLCT DCRIHFKKYG ELPPIEKPVD
560 570 580 590 600
PPPFMFKPVK EEDDGLSGKH SMRTRRSRGS MSTLRSGRKK QPASPDGRAS
610 620 630 640 650
PINEDIRSSG RNSPSAASTS SNDSKAETVK KSAKKVKEEA SSPLKSTKRQ
660 670 680 690 700
REKVASDTEE ADRTSSKKTK TQEISRPNSP SEGEGESSDS RSVNDEGSSD
710 720 730 740 750
PKDIDQDNRS TSPSIPSPQD NESDSDSSAQ QQMLQAQPPA LQAPSGANPA
760 770 780 790 800
PSTAPPGTPQ LPIAGPTTSA GPPQGSPAAP PPPNQPQAPA VSAAHTHIQQ
810 820 830 840 850
APALHPQRLP SPHPPLQPLT GPAGQTSAPP HAQPPLHSQG PPGPHSLQAG
860 870 880 890 900
SLLQHPGPPQ PFGLPPQASQ GQAPLGTPPA AAHPHTTLQL PASQSALQAQ
910 920 930 940 950
QPPREQPLPP APLAMPHIKP PPTTPIPQLP APQAHKHPPH LSGPSPFSMN
960 970 980 990 1000
ANLPPPPALK PLSSLSTHHP PSAHPPPLQL MPQSQPLPSS PAQPPGLTQS
1010 1020 1030 1040 1050
QSLPPPAAPH PPTGLHQVPP QPPFAQHPFV PGGPPPITPP TCPSTSTPPA
1060 1070 1080 1090 1100
GPSTSAQPPC AAAVSSGGSV PAGASCQLPT VQIKEEALDD AEEPESPPPP
1110 1120 1130 1140 1150
PRSPSPEPTV VDTPSHASQS ARFYKHLDRG YNSCARTDLN FMPLAGSKLA
1160 1170 1180 1190 1200
KKREEAIEKA KREAEQKARE EREREKEKEK ERERERERER EAERAAQKAS
1210 1220 1230 1240 1250
SSAHEGRLSD PQLSGPGHMR PSFEPPPTTI AAVPPYIGPD TPALRTLSEY
1260 1270 1280 1290 1300
ARPHVMSPTN RNHPFYMPLN PADPLLAYHM PGLYNVDPTI RERELREREI
1310 1320 1330 1340 1350
REREIREREL RERMKPGFEV KPPELDPLHP ATNPMEHFAR HSALTIPPTA
1360 1370 1380 1390 1400
GPHPFASFHP GLNPLERERL ALAGPQLRPE MSYPDRLAAE RIHAERMASL
1410 1420 1430 1440 1450
TSDPLARLQM FNVTPHHHQH SHIHSHLHLH QQDPLHQGSA GPVHPLVDPL
1460 1470 1480 1490 1500
TAGPHLARFP YPPGTLPNPL LGQPPHEHEM LRHPVFGAPY PRDLPGAIPP
1510 1520 1530 1540 1550
PMSAAHQLQA MHAQSAELQR LAMEQQWLHG HPHMHGGHLP SQEDYYSRLK

KEGDKQL
Length:1,557
Mass (Da):171,381
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82D8AA90B6410A83
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAQR03101333 Genomic DNA No translation available.
AAQR03101334 Genomic DNA No translation available.
AAQR03101335 Genomic DNA No translation available.
AAQR03101336 Genomic DNA No translation available.
AAQR03101337 Genomic DNA No translation available.
AAQR03101338 Genomic DNA No translation available.
AAQR03101339 Genomic DNA No translation available.
AAQR03101340 Genomic DNA No translation available.
AAQR03101341 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOGAT00000012371; ENSOGAP00000011069; ENSOGAG00000012363

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03101333 Genomic DNA No translation available.
AAQR03101334 Genomic DNA No translation available.
AAQR03101335 Genomic DNA No translation available.
AAQR03101336 Genomic DNA No translation available.
AAQR03101337 Genomic DNA No translation available.
AAQR03101338 Genomic DNA No translation available.
AAQR03101339 Genomic DNA No translation available.
AAQR03101340 Genomic DNA No translation available.
AAQR03101341 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000011069

Genome annotation databases

EnsembliENSOGAT00000012371; ENSOGAP00000011069; ENSOGAG00000012363

Phylogenomic databases

eggNOGiKOG2133, Eukaryota
GeneTreeiENSGT00940000153615
HOGENOMiCLU_005292_1_0_1
InParanoidiH0X6R3
OMAiPCRRLNS
TreeFamiTF328554

Family and domain databases

CDDicd00202, ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR002951, Atrophin-like
IPR001025, BAH_dom
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA
PfamiView protein in Pfam
PF03154, Atrophin-1, 1 hit
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit
SMARTiView protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0X6R3_OTOGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0X6R3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 7, 2020
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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