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Protein
Submitted name:

TNF receptor superfamily member 1A

Gene

TNFRSF1A

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor superfamily member 1AImported
Gene namesi
Name:TNFRSF1AImported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500354479230 – 465Sequence analysisAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Interactioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000010804

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 125TNFR-CysInterPro annotationAdd BLAST43
Repeati83 – 125TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini126 – 166TNFR-CysInterPro annotationAdd BLAST41
Repeati126 – 166TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini366 – 451DeathInterPro annotationAdd BLAST86

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
GeneTreeiENSGT00530000064001
InParanoidiH0X648
OMAiGCLEDIE
OrthoDBiEOG091G07LE
TreeFamiTF333916

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd10576 TNFRSF1A, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020419 TNFR_1A
IPR033994 TNFRSF1A_death
IPR033993 TNFRSF1A_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01918 TNFACTORR1A
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 3 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

H0X648-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VLMVMVSPLI LSQVFPTLLM GIHPSGVIGL VPLLGDREKR DSLCPQGKYS
60 70 80 90 100
HPEDNTICCT KCHKGTYLYK DCPFPGQETD CRQCENGTFT ASENHLRSCL
110 120 130 140 150
TCSQCRKELG QVEISPCTVD RDTVCGCRKN QYRHYWSDNL FQCFECKLCL
160 170 180 190 200
NGTVVLPCQE KQNTVCTCHF GYYLKENDCV PCSDCKKKEC LKLCQIRGSE
210 220 230 240 250
PVNSPSNPDT SVLLPLVIFL GLCLLSLLFI CLMCRYQKWK PKLYSIVCGR
260 270 280 290 300
PTPEKEGELE GITTKPLASV PGFSPTLGFT PTSAFSPTSG FSPSPGFSPI
310 320 330 340 350
PCPTFTPTHT FIPSSNYTPM TSPREVAPPH LGAEPILNTP PASTLSPTLL
360 370 380 390 400
QKPEDTAHTL RSDTDPAMLY AVVDGVPPSR WKEFVRRLGL SEHEIERLEI
410 420 430 440 450
QNGRCLREAH YSMLEAWRRR TPRREATLEL LGRVLGDMDL LGCLEDIIEA
460
LRGPASLSSA PRLPR
Length:465
Mass (Da):51,707
Last modified:February 22, 2012 - v1
Checksum:iFE0B10FE009564F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03127907 Genomic DNA No translation available.
AAQR03127908 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSOGAT00000012076; ENSOGAP00000010804; ENSOGAG00000012073

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03127907 Genomic DNA No translation available.
AAQR03127908 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000010804

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOGAT00000012076; ENSOGAP00000010804; ENSOGAG00000012073

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
GeneTreeiENSGT00530000064001
InParanoidiH0X648
OMAiGCLEDIE
OrthoDBiEOG091G07LE
TreeFamiTF333916

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd10576 TNFRSF1A, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020419 TNFR_1A
IPR033994 TNFRSF1A_death
IPR033993 TNFRSF1A_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01918 TNFACTORR1A
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 3 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0X648_OTOGA
AccessioniPrimary (citable) accession number: H0X648
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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