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Protein
Submitted name:

ATP binding cassette subfamily C member 11

Gene

ABCC11

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi547 – 554ATPPROSITE-ProRule annotation8
Nucleotide bindingi1183 – 1190ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP binding cassette subfamily C member 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri30611 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei163 – 184HelicalSequence analysisAdd BLAST22
Transmembranei199 – 226HelicalSequence analysisAdd BLAST28
Transmembranei275 – 299HelicalSequence analysisAdd BLAST25
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei380 – 404HelicalSequence analysisAdd BLAST25
Transmembranei416 – 438HelicalSequence analysisAdd BLAST23
Transmembranei809 – 832HelicalSequence analysisAdd BLAST24
Transmembranei870 – 890HelicalSequence analysisAdd BLAST21
Transmembranei939 – 961HelicalSequence analysisAdd BLAST23
Transmembranei967 – 986HelicalSequence analysisAdd BLAST20
Transmembranei1052 – 1073HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
30611.ENSOGAP00000005712

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini164 – 443ABC transmembrane type-1InterPro annotationAdd BLAST280
Domaini514 – 735ABC transporterInterPro annotationAdd BLAST222
Domaini813 – 1077ABC transmembrane type-1InterPro annotationAdd BLAST265
Domaini1149 – 1383ABC transporterInterPro annotationAdd BLAST235

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162968

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0WU37

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEGVYYG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01TC

TreeFam database of animal gene trees

More...
TreeFami
TF352085

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF168 PTHR24223:SF168, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H0WU37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRKKTYWVP NSSGGLVNLG MDLQDDRVSG LSYKTYPLKD SLWSQQESKP
60 70 80 90 100
EAREGTDVLP SGKYDTAWKN MIPFRPKPRF PAPNPVDDAG LFSYLTVSWL
110 120 130 140 150
TPLMIQGLRN RLDENTIPPL SVHDASAKNV QRLHRLWEEE VSRRGTEKAS
160 170 180 190 200
VLRVMLRFQR TRIVLSGLAC CCFIIMSVLG PTLIVPRILE YSAEQSGDIV
210 220 230 240 250
YGVGLCFTLF LSECLKSVSF CSTWIINQRT GMRFRGAISC FAFEKLLQFR
260 270 280 290 300
SLTHITSGEA INFFTSDINY LFEGVYYGPL LLIAAMSLIA CTIATCFILG
310 320 330 340 350
PTALVAIFCY LLVFPVEAFI TRLILKMQHH ISEVSDQRIR ATSEVLTCIK
360 370 380 390 400
LIKMYTWEKP FAKVIEDLRR KERKLMEKSG FLQSLTTVSL FINPTVAMAV
410 420 430 440 450
MILIHVSLKR KLTATLAFTT MATLNLLRLS AFILPFAAKG LTNSKSALER
460 470 480 490 500
FKKFFLQESP VFYVQELQDP SKAVVLEEAT LSWQQTCPGM VNGALELEQN
510 520 530 540 550
GHASEGMTRA QPPLDALRPE YKEHSLAPAL LKINLVVSKG TLVGVCGNTG
560 570 580 590 600
SGKSSLLSGI LGEMHLIEGS VGVCGTLAYV PQQAWIIQGS VRDNILMGGQ
610 620 630 640 650
YDKARYLQVL SCCSLSRDLE LLPFGDMTEI GERGLNLSGG QKQRISMARA
660 670 680 690 700
VYSDRQLYLL DDPLSAVDVH VGKHIFEECI KKILKEKTVV LVTHQLQHQH
710 720 730 740 750
LCQRIVLLED GKICEHGTHS ELMQKKGQYA QLFQKIYPEE ATQDIPQDTA
760 770 780 790 800
ETAKKSQAED QAQATSQEDS LSENADLVPE HQLTYEEKME EGALSWSVYH
810 820 830 840 850
RYMQAAGGYV VSFLALLLLV VFICLTIFNF WWLSYWLEQG SGTNSSQESN
860 870 880 890 900
RTTADPGDIM DNPQLSFYEM VYGLSLVFLV CVGVCSSGVF TKVTRKASTA
910 920 930 940 950
LHNQLFSKVF RCPMSFFDTT PTGRLLNCFA GDLDELDQFL PVAAEQFLLL
960 970 980 990 1000
SLLIIAILLL IVMLSPYVLL LTAVVMGFCL IYYKVFRRVI NLFKRLDSYS
1010 1020 1030 1040 1050
RSPVFSHILT SLHGLSSIHV YEKTEAFFNR FKRLTDTQNN YQLLFLASTR
1060 1070 1080 1090 1100
WAALRLEIMI NLLTLAVALF LAFDISSTSQ SYRAMAIGLL LQLASNFQAT
1110 1120 1130 1140 1150
ARIGSETEAH FTAIERMLKY MKNKMCVSEA PLHVEGTSCP PGWPQQGQIT
1160 1170 1180 1190 1200
FQDYEMKYRD NTPVVLHGIN LTIHGREVVG IVGRTGSGKS SLGMALFRLV
1210 1220 1230 1240 1250
EPAAGRILID GVDICSIGLE DLRSKLSVIP QDPVLLSGTI RFNLDPFDCY
1260 1270 1280 1290 1300
TDEQIWDVLE RTFLAKIISR LPSRLQAEVL ENGENFSVGQ RQLLCIARAL
1310 1320 1330 1340 1350
LRNSKIVLID EATASIDMET DALIQCTIRE AFQGCTVLVI AHRITTILNC
1360 1370 1380 1390
DRILVMDSGR VLEFDRPEVL QKQPGSVFAA LLARASSSLS
Length:1,390
Mass (Da):155,515
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62EEEEC5E2C8E437
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAQR03091946 Genomic DNA No translation available.
AAQR03091947 Genomic DNA No translation available.
AAQR03091948 Genomic DNA No translation available.
AAQR03091949 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOGAT00000006396; ENSOGAP00000005712; ENSOGAG00000006391

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03091946 Genomic DNA No translation available.
AAQR03091947 Genomic DNA No translation available.
AAQR03091948 Genomic DNA No translation available.
AAQR03091949 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000005712

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOGAT00000006396; ENSOGAP00000005712; ENSOGAG00000006391

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000162968
InParanoidiH0WU37
OMAiFEGVYYG
OrthoDBiEOG091G01TC
TreeFamiTF352085

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF168 PTHR24223:SF168, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0WU37_OTOGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0WU37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: December 5, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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