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Protein

Heparan-sulfate 6-O-sulfotransferase

Gene

HS6ST2

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.UniRule annotation

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferaseUniRule annotation (EC:2.8.2.-UniRule annotation)
Gene namesi
Name:HS6ST2Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei154 – 172HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSCPOG00000021403

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3955 Eukaryota
ENOG410XSW4 LUCA
GeneTreeiENSGT00390000013468

Family and domain databases

InterProiView protein in InterPro
IPR010635 Heparan_SO4-6-sulfoTrfase
IPR027417 P-loop_NTPase
IPR005331 Sulfotransferase
PANTHERiPTHR12812 PTHR12812, 1 hit
PfamiView protein in Pfam
PF03567 Sulfotransfer_2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

H0W1Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPACAARA LGPPLQPEHG APARTTCPRR HSRVEAELAA SRPGSVSASV
60 70 80 90 100
RAGPPRGVSH GFNSRQLLDE PLKASASLAG ALRAPLFALL PRGRRRRMND
110 120 130 140 150
LRRRWDLGSL CRALLTRGLA ALGHSLKHVL SAIFSKIFGP LASVGNMDEK
160 170 180 190 200
SNKLLLALVM FFLFAVIVLQ YVCPGTECQL LRLQAFSSPL PDPYRSEDES
210 220 230 240 250
SARFVPRYNF SRGDLLRKVD FDINGDDLIV FLHIQKTGGT TFGRHLVRNI
260 270 280 290 300
QLEQPCECRV GQKKCTCHRP GKRETWLFSR FSTGWSCGLH ADWTELTSCV
310 320 330 340 350
PAVVDGKRDA RLRPSRNFHY ITILRDPVSR YLSEWRHVQR GATWKASLHV
360 370 380 390 400
CDGRPPTSEE LPSCYTGDDW SGCPLKEFMD CPYNLANNRQ VRMLSDLTLV
410 420 430 440 450
GCYNLSVMPE KQRNKVLLES AKSNLKHMAF FGLTEFQRKT QYLFEKTFNM
460 470 480 490 500
NFISPFTQYN TTRASSVEIN EDIQKRIERL NFLDMELYSY AKDLFLQRYQ
510 520 530 540 550
FMRQKEHQEA RRKRQEQRKF LKGRFLQTHF QSQSQSQSQN PSQNQSQNPN
560 570 580 590 600
PNANQSLTQN LIQNLTQNSS QNLSQKENRS NQKQSPGHKQ NDSSSGSSGT
610
NDYIGSVEKW R
Length:611
Mass (Da):69,547
Last modified:November 22, 2017 - v2
Checksum:iD4281793B246E519
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02053325 Genomic DNA No translation available.
AAKN02053326 Genomic DNA No translation available.
RefSeqiXP_003462707.1, XM_003462659.3

Genome annotation databases

EnsembliENSCPOT00000023221; ENSCPOP00000016970; ENSCPOG00000021403
GeneIDi100721660

Similar proteinsi

Entry informationi

Entry nameiH0W1Y0_CAVPO
AccessioniPrimary (citable) accession number: H0W1Y0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 33 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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