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Protein
Submitted name:

Adenylate cyclase 9

Gene

ADCY9

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandNucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 9Imported
Gene namesi
Name:ADCY9Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei142 – 165HelicalSequence analysisAdd BLAST24
Transmembranei172 – 193HelicalSequence analysisAdd BLAST22
Transmembranei242 – 261HelicalSequence analysisAdd BLAST20
Transmembranei788 – 809HelicalSequence analysisAdd BLAST22
Transmembranei821 – 845HelicalSequence analysisAdd BLAST25
Transmembranei866 – 884HelicalSequence analysisAdd BLAST19
Transmembranei890 – 910HelicalSequence analysisAdd BLAST21
Transmembranei977 – 996HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSCPOG00000019749 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000015052

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 521Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini1058 – 1198Guanylate cyclaseInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3618 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000119042
InParanoidiH0VWH4
OMAiFETNIHF
OrthoDBiEOG091G0285
TreeFamiTF313845

Family and domain databases

CDDicd06174 MFS, 1 hit
Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR020846 MFS_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequencei

Sequence statusi: Complete.

H0VWH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN SHPKHCKYSI
60 70 80 90 100
SSSCSSSGDS GGLPRRVGGR SRLRRQRKLP QLFERASSRW WDPKFDSVNL
110 120 130 140 150
EEACLERCFP QTQRRFRYAL FYVGFACLLW SIYFAVHMRS KLIVMVAPPL
160 170 180 190 200
CFLVVCVGFF LFTFTKLYTR HYAWTSLALT LLVFALTLAA QFQVLTPLSG
210 220 230 240 250
HVDSSNRTPT ARPADICLSQ VGSFSMCIEV LFLLYTVMHL PLYLSLFLGV
260 270 280 290 300
VYSVLFETFG FHFRDEDCFP SPEARALHWE LLSRALLHVC IHAIGIHLFV
310 320 330 340 350
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG
360 370 380 390 400
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI
410 420 430 440 450
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EETKCEKIST LGDCYYCVAG
460 470 480 490 500
CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL
510 520 530 540 550
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGKV
560 570 580 590 600
IERLGQSMVA DQLKGLKTYL ISGQRAKESH CSCAEALLSG FEAIDGSRVS
610 620 630 640 650
SGPRGQGTAS SGSVSDLAQT VKTFDNLKTC PSRGIVFAPK SEGGAEGGTV
660 670 680 690 700
QNGCQDESKT STKISGGPSS KAQNGLLSPP QEEKLTNSQT SLCEILQEKG
710 720 730 740 750
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF
760 770 780 790 800
SLNFLDQELE RSYKTSYQEE VIKNSPVKTF ASATFSSLLD VLLSTTVFLI
810 820 830 840 850
LSVTCFLKYG ATATPPSPAA LAIFGAALLL EVLSLVVSIR MVFFLEDVMV
860 870 880 890 900
CTQRLLEWIA GWLPRHCIGA VLVSLPALAV YSHITSEFET NVHFTVFTSS
910 920 930 940 950
AVLVAVVHYC NFCQLSSWMR SSLATIVGAG PLLLLYISLC PDSSIVISPL
960 970 980 990 1000
DVAQNFSAAR SPCNSSLTLD SRRPTSLVGK ELILAFFLLL LLVWFLNREF
1010 1020 1030 1040 1050
EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY
1060 1070 1080 1090 1100
SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD
1110 1120 1130 1140 1150
YNSIEKIKTI GATYMAASGL NTAQCQEGSH PQEHLRILFE FAKEMMRVVD
1160 1170 1180 1190 1200
DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT
1210 1220 1230 1240 1250
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCVDNGV
1260 1270 1280 1290 1300
VPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVPYSDK TSLGSDDNTP
1310 1320 1330 1340 1350
AKDTHLYSKR PWKEPIKVEE RCQFGKAIEK DDCEDMGMEE ANELTKLNVS

KSV
Length:1,353
Mass (Da):151,221
Last modified:February 22, 2012 - v1
Checksum:i6EE3DD01ABEC4031
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02007428 Genomic DNA No translation available.
RefSeqiXP_005007521.1, XM_005007464.2

Genome annotation databases

EnsembliENSCPOT00000020317; ENSCPOP00000015052; ENSCPOG00000019749
ENSCPOT00000040128; ENSCPOP00000025845; ENSCPOG00000019749
GeneIDi100717226

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02007428 Genomic DNA No translation available.
RefSeqiXP_005007521.1, XM_005007464.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000015052

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000020317; ENSCPOP00000015052; ENSCPOG00000019749
ENSCPOT00000040128; ENSCPOP00000025845; ENSCPOG00000019749
GeneIDi100717226

Organism-specific databases

CTDi115

Phylogenomic databases

eggNOGiKOG3618 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000119042
InParanoidiH0VWH4
OMAiFETNIHF
OrthoDBiEOG091G0285
TreeFamiTF313845

Gene expression databases

BgeeiENSCPOG00000019749 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd06174 MFS, 1 hit
Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR020846 MFS_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0VWH4_CAVPO
AccessioniPrimary (citable) accession number: H0VWH4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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