Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 44 (05 Jun 2019)
Sequence version 2 (22 Nov 2017)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

KANSL1

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KANSL1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCavia porcellus (Guinea pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10141 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005447 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCPOG00000013025 Expressed in 3 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10141.ENSCPOP00000011725

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini880 – 1030PEHEInterPro annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni156 – 181DisorderedSequence analysisAdd BLAST26
Regioni224 – 249DisorderedSequence analysisAdd BLAST26
Regioni397 – 422DisorderedSequence analysisAdd BLAST26
Regioni687 – 716DisorderedSequence analysisAdd BLAST30
Regioni729 – 851DisorderedSequence analysisAdd BLAST123
Regioni933 – 995DisorderedSequence analysisAdd BLAST63
Regioni1011 – 1031DisorderedSequence analysisAdd BLAST21
Regioni1044 – 1100DisorderedSequence analysisAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili282 – 309Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 180PolarSequence analysisAdd BLAST24
Compositional biasi778 – 798PolyampholyteSequence analysisAdd BLAST21
Compositional biasi799 – 848PolarSequence analysisAdd BLAST50
Compositional biasi933 – 989PolarSequence analysisAdd BLAST57
Compositional biasi1014 – 1028PolarSequence analysisAdd BLAST15
Compositional biasi1046 – 1067PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1068 – 1100PolarSequence analysisAdd BLAST33

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKZN Eukaryota
ENOG410ZYQQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063688

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0VMS9

Database of Orthologous Groups

More...
OrthoDBi
191128at2759

TreeFam database of animal gene trees

More...
TreeFami
TF336511

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026180 NSL1
IPR029332 PEHE_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22443 PTHR22443, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15275 PEHE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01300 PEHE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H0VMS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAMAPALTD AAAEAHHIRF KLAPPSSTLS PGSAENNGNA NILIAANGTK
60 70 80 90 100
RKAIAAEDPS LDFRNKPKED LGKLQPLVAS YLCSDVTSVP QKESLKLQGV
110 120 130 140 150
FSKQAVLKSH PLLSQSYEFR AELLGRQPVL EFSLENLRTM NTSGQMALPQ
160 170 180 190 200
APVNGLAKKL TKSSTHSDHD NSSPLNGGKR ALTSALQGGE VGISDSGDLK
210 220 230 240 250
GGMTNCTLPH RSLDVEHTTL YSNNSTANKS SVNSVEQPAL QGSSRLLPGT
260 270 280 290 300
DCSPNLGSVK LEGKKSHMSS ILLSALDSDT RITALLRRQA DIESRARRLQ
310 320 330 340 350
KRLQVVQAKQ VERHLQHQLG GFLEKTLSKL PNLESLKSRS QLMLTRKAEA
360 370 380 390 400
ALRKAASETT TSEGLSNFLK SDSISEELER FTVSGIANLR CSEQAFDSDI
410 420 430 440 450
TDSSSGGESD IEEEELTRAD SEQCHVPLKR RSEWKWAADR AAIVSRWNWL
460 470 480 490 500
QAHVSDLEYR IRQQTDIYKQ IRANKGLIVL GEASPSEHTT DVLLPLGSEV
510 520 530 540 550
KTDHGTDKFI ESVSQPLENR GPPVGHISES LSTKSCGTLR PVNGVINTLQ
560 570 580 590 600
PVLADHVPGD SSDAEEQLHK KQRLNLVSSS DGTCVAARTR PVLSCKKRRL
610 620 630 640 650
VRPSSIVPLS KKVHRNSITR FGCDVNTSCA LCGSSSVNTV PPEIHYEAPL
660 670 680 690 700
LERLSQLDSC IHPVLAFPDD VPTSLHFQSM LKSQWQNKPF DKSKPPKKFS
710 720 730 740 750
LKHRAPMQSS VTDPTRKDRH KLVNSFLTTA KLSHHQTRPD RTHRQHLDDV
760 770 780 790 800
GAVPMVERVT APKAERLLNP PPPVHDPNHS KMRLRDHSSE RSEVLKHHTD
810 820 830 840 850
ISSSSYLATT HHTPHSPLVR QLSASSDTSV PTSSSSQVSA STSQPVRRRR
860 870 880 890 900
GESSFDINNI VIPMSVAATT RVEKLQYKEI LTPSWREVDL QSLKGNPDEE
910 920 930 940 950
SEEIEDLSDA AFAALHAKCE EMERARWLWT TSVPPQRRGS RSYRSSDGRT
960 970 980 990 1000
TPQLGSANPS TPQPASPDVS SSHSLSEFSH CQSPRSPISP ELHSAPLTPV
1010 1020 1030 1040 1050
ARDTLRHLAS EDTRCSTPEL SLDEQSVQPW ERRTFPLPYS PQAECEDHLD
1060 1070 1080 1090 1100
PQERAARCTR RTSGSKTGRE TEMAPTSPPT VTLKSRHLAA TVTAQRPTHR
Length:1,100
Mass (Da):120,909
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D10F9C444FE186A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286Y2Q6A0A286Y2Q6_CAVPO
Uncharacterized protein
KANSL1
1,037Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAKN02045153 Genomic DNA No translation available.
AAKN02045154 Genomic DNA No translation available.
AAKN02045155 Genomic DNA No translation available.
AAKN02045156 Genomic DNA No translation available.
AAKN02045157 Genomic DNA No translation available.
AAKN02045158 Genomic DNA No translation available.
AAKN02045159 Genomic DNA No translation available.
AAKN02045160 Genomic DNA No translation available.
AAKN02045161 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_003465965.1, XM_003465917.3
XP_005002024.1, XM_005001967.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCPOT00000013151; ENSCPOP00000011725; ENSCPOG00000013025
ENSCPOT00000034541; ENSCPOP00000024938; ENSCPOG00000013025

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100713349

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02045153 Genomic DNA No translation available.
AAKN02045154 Genomic DNA No translation available.
AAKN02045155 Genomic DNA No translation available.
AAKN02045156 Genomic DNA No translation available.
AAKN02045157 Genomic DNA No translation available.
AAKN02045158 Genomic DNA No translation available.
AAKN02045159 Genomic DNA No translation available.
AAKN02045160 Genomic DNA No translation available.
AAKN02045161 Genomic DNA No translation available.
RefSeqiXP_003465965.1, XM_003465917.3
XP_005002024.1, XM_005001967.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011725

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000013151; ENSCPOP00000011725; ENSCPOG00000013025
ENSCPOT00000034541; ENSCPOP00000024938; ENSCPOG00000013025
GeneIDi100713349

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284058

Phylogenomic databases

eggNOGiENOG410IKZN Eukaryota
ENOG410ZYQQ LUCA
GeneTreeiENSGT00530000063688
InParanoidiH0VMS9
OrthoDBi191128at2759
TreeFamiTF336511

Gene expression databases

BgeeiENSCPOG00000013025 Expressed in 3 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR026180 NSL1
IPR029332 PEHE_dom
PANTHERiPTHR22443 PTHR22443, 1 hit
PfamiView protein in Pfam
PF15275 PEHE, 1 hit
SMARTiView protein in SMART
SM01300 PEHE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0VMS9_CAVPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0VMS9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: November 22, 2017
Last modified: June 5, 2019
This is version 44 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again