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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene

MED6

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6UniRule annotation
Alternative name(s):
Mediator complex subunit 6UniRule annotation
Gene namesi
Name:MED6Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSCPOG00000012529 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Component of the Mediator complex.UniRule annotation

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011273

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3169 Eukaryota
COG5097 LUCA
GeneTreeiENSGT00390000017666
InParanoidiH0VLM8
OMAiYARYHPN
OrthoDBiEOG091G0MJA
TreeFamiTF313577

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H0VLM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV
60 70 80 90 100
KMQRLTLEHL NQMVGIEYIL LHAQEPILFI IRKQQRQSPA QVIPLADYYI
110 120 130 140 150
IAGVIYQAPD LGSVINSRVL TAVHGIQSAF DEAMSYCRYH PSKGYWWHFK
160 170 180 190 200
DHEEQDKVKP KAKRKEEPSS IFQRQRVDAL LVDLRQRFPP KFVQQKSGEK
210 220 230 240
PIPVDQTKKE AEPIPETVKS EEKETIKNVQ QTLNTKGPPE KRIRLQ
Length:246
Mass (Da):28,485
Last modified:February 22, 2012 - v1
Checksum:i67F80FFCD766B423
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286XJ09A0A286XJ09_CAVPO
Mediator of RNA polymerase II trans...
MED6
196Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02025255 Genomic DNA No translation available.
RefSeqiXP_003472437.1, XM_003472389.3

Genome annotation databases

EnsembliENSCPOT00000012649; ENSCPOP00000011273; ENSCPOG00000012529
GeneIDi100725663

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02025255 Genomic DNA No translation available.
RefSeqiXP_003472437.1, XM_003472389.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011273

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000012649; ENSCPOP00000011273; ENSCPOG00000012529
GeneIDi100725663

Organism-specific databases

CTDi10001

Phylogenomic databases

eggNOGiKOG3169 Eukaryota
COG5097 LUCA
GeneTreeiENSGT00390000017666
InParanoidiH0VLM8
OMAiYARYHPN
OrthoDBiEOG091G0MJA
TreeFamiTF313577

Gene expression databases

BgeeiENSCPOG00000012529 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0VLM8_CAVPO
AccessioniPrimary (citable) accession number: H0VLM8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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