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Entry version 54 (26 Feb 2020)
Sequence version 2 (22 Nov 2017)
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Protein
Submitted name:

AT-rich interaction domain 1A

Gene

ARID1A

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AT-rich interaction domain 1AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID1AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCavia porcellus (Guinea pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10141 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005447 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCPOG00000010387 Expressed in brain and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10141.ENSCPOP00000009330

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini632 – 723ARIDInterPro annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 437DisorderedSequence analysisAdd BLAST437
Regioni593 – 620DisorderedSequence analysisAdd BLAST28
Regioni728 – 1097DisorderedSequence analysisAdd BLAST370
Regioni1119 – 1249DisorderedSequence analysisAdd BLAST131
Regioni1359 – 1399DisorderedSequence analysisAdd BLAST41
Regioni1503 – 1524DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 28PolarSequence analysisAdd BLAST16
Compositional biasi35 – 98PolarSequence analysisAdd BLAST64
Compositional biasi108 – 134PolarSequence analysisAdd BLAST27
Compositional biasi149 – 257PolarSequence analysisAdd BLAST109
Compositional biasi273 – 301PolarSequence analysisAdd BLAST29
Compositional biasi317 – 332PolarSequence analysisAdd BLAST16
Compositional biasi344 – 415PolarSequence analysisAdd BLAST72
Compositional biasi742 – 772PolarSequence analysisAdd BLAST31
Compositional biasi789 – 837PolarSequence analysisAdd BLAST49
Compositional biasi916 – 987PolarSequence analysisAdd BLAST72
Compositional biasi1007 – 1051PolarSequence analysisAdd BLAST45
Compositional biasi1081 – 1095PolarSequence analysisAdd BLAST15
Compositional biasi1119 – 1137PolarSequence analysisAdd BLAST19
Compositional biasi1164 – 1190Pro-richSequence analysisAdd BLAST27
Compositional biasi1383 – 1399AcidicSequence analysisAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2510 Eukaryota
ENOG410Y034 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155194

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000974_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0VGS4

Database of Orthologous Groups

More...
OrthoDBi
256110at2759

TreeFam database of animal gene trees

More...
TreeFami
TF320364

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.60, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
IPR030094 BAF250a

The PANTHER Classification System

More...
PANTHERi
PTHR12656 PTHR12656, 1 hit
PTHR12656:SF12 PTHR12656:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H0VGS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQMGKMRPQ PYGGTNPYSQ QQGPPSGPQQ GHGYPGQPYG SQTPQRYPMT
60 70 80 90 100
MQSRAQSAMG SLSYAQQIPP YGQQGPSGYG QQGQTPYYNQ QSPHPQQQQP
110 120 130 140 150
PYSQQPPSQT PHAQSSYQQQ PQSQPQLQSS QPPYSQQPSQ PPHQQSPTPY
160 170 180 190 200
PSQQSTTQQH PQSQPPYSQP QAQSPYQQQQ PQQPASSTLS QQAAYPQPQS
210 220 230 240 250
QQPQQTAYSQ QRFPPPQELS QDSFGSQASS APSMTSSKGG QEDMNLSLQS
260 270 280 290 300
RPSSLPDLSG SIDDLPMGTE GALSPGVSTS GISSSQGEQS NPAQSPFSPH
310 320 330 340 350
TSPHLPGIRG PSPSPVGSPA SVAQSRSGPL SPAAVPGNQM PPRPPSGQSD
360 370 380 390 400
SIMHPSMNQS SIAQDRGYMQ RNPQMPQYSS PQPGSALSPR QPSGGQMHTG
410 420 430 440 450
MGSYQQNSMG SYGPQGGQYG PQGGYPRQPN YNALPNANYP SAGMAGSMNP
460 470 480 490 500
MGAGGQMHGQ PGIPPYGTLP PGRMSHASMG NRPYGPNMAN MPPQVGSGMC
510 520 530 540 550
PPPGSMNRKT QESAVAMHVA ANSIQNRPPG YPNMNQGGMM GTGPPYGQGI
560 570 580 590 600
NSMAGMINPQ GPPYPMGGTM ANNSGMAASP EMMGLGDVKL TPATKMNNKA
610 620 630 640 650
DGTPKTESKS KKSSSSTTTN EKITKLYELG GEPERKMWVD RYLAFTEEKA
660 670 680 690 700
MGMTNLPAVG RKPLDLYRLY VSVKEIGGLT QVNKNKKWRE LATNLNVGTS
710 720 730 740 750
SSAASSLKKQ YIQCLYAFEC KIERGEDPPP DIFAAADSKK SQPKIQPPSP
760 770 780 790 800
AGSGSMQGPQ TPQSTSSSMA EGGDLKPPTP ASTPHSQIPP LPGMRSNSVG
810 820 830 840 850
IQDTFPDGSD PTFQKRNSMT PNPGYQPSMN TSDMMGRMSY EPNKDPYGSM
860 870 880 890 900
RKAPGSDPFM SSGQGPNGSG MGDPYSRTAG PGLGNVSMGP RQHYPYGGPY
910 920 930 940 950
DRVRTEPGIG PEGNMGTGAP QQNLMPSTPD SGMYSPSRYP PQQQQQQQQR
960 970 980 990 1000
HDSYGNQFST QGTPSGNPFP SQQTTMYQQQ QQNYKRPMDG TYGPPAKRHE
1010 1020 1030 1040 1050
GEMYSVPYST GQGQPQQQLP PAQSQSASQQ QAAQPSPQQD VYNQYGNAYP
1060 1070 1080 1090 1100
ATATAATERR PAGGPQNQFP FQFGRDRVSA PPGSNAQQNM PPQMMGGPIQ
1110 1120 1130 1140 1150
ASAEVAQQGT MWQGRNDMTY NYANRQSTGS APQGPTYHGV NRTDEMLHTD
1160 1170 1180 1190 1200
QRANHEGPWP SHGSRQPPYG PSAPVPPMTR PPPSNYQPPP SMQNHIPQVS
1210 1220 1230 1240 1250
SPAPLPRPME NRTSPSKSPF LHSGMKMQKA GPPVPASHIA PTPVQPPMIR
1260 1270 1280 1290 1300
RDITFPPGSV EATQPVLKQR RRLTMKDIGT PEAWRVMMSL KSGLLAESTW
1310 1320 1330 1340 1350
ALDTINILLY DDNSIMTFNL SQLPGLLELL VEYFRRCLIE IFGILKEYEV
1360 1370 1380 1390 1400
GDPGQRTLLD PGRFSKVSSP TPTEGEEEEE LLSPKLKEEE EEEEEEEIVE
1410 1420 1430 1440 1450
NDEEMAFLGK DKPALENSEE KLISKFDKLP VKIVQKNDPF VVDCSDKLGR
1460 1470 1480 1490 1500
VQEFDSGLLH WRIGGGDTTE HIQTHFESKT ELLPSRSPVP CSTAPRKHVV
1510 1520 1530 1540 1550
TVEGTAGRTT EQEGPPPDGL PEKRITATMD DMLSTRSSTL TEEGAKNAEA
1560 1570 1580 1590 1600
AKESSKFPFG ISPAQSHRNI KILEDEPHSK DETPLCTLLD WQDSLAKRCI
1610 1620 1630 1640 1650
CVSNTIRSLS FVPGNDFEMS KHPGLLLILG KLILLHHKHP ERKQAPLTYE
1660 1670 1680 1690 1700
KEEEQDQGVS CNKVEWWWDC LEMLRENTLV TLANISGQLD LSPYPESICL
1710 1720 1730 1740 1750
PVLDGLLHWA VCPSAEAQDP FSTLGPNAVL SPQRLVLETL SKLSIQDNNV
1760 1770 1780 1790 1800
DLILATPPFS RLEKLYSTMV RFLSDRKNPV CREMAVVLLA NLAQGDSLAA
1810 1820 1830 1840 1850
RAIAVQKGSI GNLLGFLEDS LAATQFQQSQ ASLLHMQNPP FEPTSVDMMR
1860 1870 1880 1890 1900
RAARALLALA KVDENHSEFT LYESRLLDIS VSPLMNSLVS QVICDVLFLI

GQS
Length:1,903
Mass (Da):206,601
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88C3CC008C31CEA7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAKN02028653 Genomic DNA No translation available.
AAKN02028654 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005004325.1, XM_005004268.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCPOT00000010481; ENSCPOP00000009330; ENSCPOG00000010387

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100714305

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02028653 Genomic DNA No translation available.
AAKN02028654 Genomic DNA No translation available.
RefSeqiXP_005004325.1, XM_005004268.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000009330

Genome annotation databases

EnsembliENSCPOT00000010481; ENSCPOP00000009330; ENSCPOG00000010387
GeneIDi100714305

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8289

Phylogenomic databases

eggNOGiKOG2510 Eukaryota
ENOG410Y034 LUCA
GeneTreeiENSGT00940000155194
HOGENOMiCLU_000974_1_1_1
InParanoidiH0VGS4
OrthoDBi256110at2759
TreeFamiTF320364

Gene expression databases

BgeeiENSCPOG00000010387 Expressed in brain and 2 other tissues

Family and domain databases

Gene3Di1.10.150.60, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
IPR030094 BAF250a
PANTHERiPTHR12656 PTHR12656, 1 hit
PTHR12656:SF12 PTHR12656:SF12, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0VGS4_CAVPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0VGS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: November 22, 2017
Last modified: February 26, 2020
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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