UniProtKB - H0V6E8 (H0V6E8_CAVPO)
Protein
Homeobox domain-containing protein
Gene
GSX2
Organism
Cavia porcellus (Guinea pig)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 191 – 250 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: Ensembl
- sequence-specific double-stranded DNA binding Source: Ensembl
GO - Biological processi
- forebrain dorsal/ventral pattern formation Source: Ensembl
- forebrain morphogenesis Source: Ensembl
- hindbrain morphogenesis Source: Ensembl
- neuron fate specification Source: Ensembl
- olfactory bulb interneuron differentiation Source: Ensembl
- positive regulation of Notch signaling pathway Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- regulation of cell migration Source: Ensembl
- regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
- spinal cord association neuron differentiation Source: Ensembl
- subpallium neuron fate commitment Source: Ensembl
- telencephalon regionalization Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox domain-containing proteinInterPro annotation |
Gene namesi | Name:GSX2Imported |
Organismi | Cavia porcellus (Guinea pig)Imported |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 189 – 249 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 140 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 271 – 293 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 100 – 114 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000156043 |
HOGENOMi | CLU_077153_0_0_1 |
InParanoidi | H0V6E8 |
OMAi | PRRYHCL |
OrthoDBi | 1341872at2759 |
TreeFami | TF315938 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR042191, GSH2 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
PANTHERi | PTHR47421, PTHR47421, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H0V6E8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRSFYVDSL IIKDSSRPAP PLPEPHPGPD FFIPLGMPSP LVMSVSGPGC
60 70 80 90 100
PSCKSGALCV CPLCVTSHLH SSRAPAGAGG GGSGAGDAGV GGSGATGGTG
110 120 130 140 150
TLPLLKSQFS SGPGDAQFCP RVSHAHHHHH QPQQPASAAA AAAAAAAAAA
160 170 180 190 200
ALGHPQHHAP VCAATTYNVA DPRRFHCLTM GGSDTSQVSN GKRMRTAFTS
210 220 230 240 250
TQLLELEREF SSNMYLSRLR RIEIATYLNL SEKQVKIWFQ NRRVKHKKEG
260 270 280 290
KGTQRNSHAG CKCVGSQAHY ARSEDEDSLS PASPNDDKEI SPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAKN02028273 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSCPOT00000005900; ENSCPOP00000005265; ENSCPOG00000005837 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAKN02028273 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000005265 |
Genome annotation databases
Ensembli | ENSCPOT00000005900; ENSCPOP00000005265; ENSCPOG00000005837 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000156043 |
HOGENOMi | CLU_077153_0_0_1 |
InParanoidi | H0V6E8 |
OMAi | PRRYHCL |
OrthoDBi | 1341872at2759 |
TreeFami | TF315938 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR042191, GSH2 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
PANTHERi | PTHR47421, PTHR47421, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0V6E8_CAVPO | |
Accessioni | H0V6E8Primary (citable) accession number: H0V6E8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | October 7, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |