RXRA

Functionⁱ

GO - Molecular functionⁱ

chromatin DNA binding Source: Ensembl
DNA binding domain binding Source: Ensembl
enzyme binding Source: Ensembl
identical protein binding Source: Ensembl
LBD domain binding Source: Ensembl
nuclear receptor activity Source: Ensembl
nuclear receptor binding Source: Ensembl
peptide binding Source: Ensembl
retinoic acid binding Source: Ensembl
retinoic acid-responsive element binding Source: Ensembl
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: Ensembl
steroid hormone receptor activity Source: InterPro
vitamin D receptor binding Source: Ensembl
vitamin D response element binding Source: Ensembl
zinc ion binding Source: Ensembl

GO - Biological processⁱ

camera-type eye development Source: Ensembl
cardiac muscle cell proliferation Source: Ensembl
embryo implantation Source: Ensembl
in utero embryonic development Source: Ensembl
maternal placenta development Source: Ensembl
modulation by virus of host process Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
peroxisome proliferator activated receptor signaling pathway Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of translational initiation by iron Source: Ensembl
regulation of branching involved in prostate gland morphogenesis Source: Ensembl
response to retinoic acid Source: Ensembl
retinoic acid receptor signaling pathway Source: Ensembl
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl
ventricular cardiac muscle cell differentiation Source: Ensembl
ventricular cardiac muscle tissue morphogenesis Source: Ensembl

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:RXRAImported
Organismⁱ	Cavia porcellus (Guinea pig)Imported
Taxonomic identifierⁱ	10141 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia
Proteomesⁱ	UP000005447 Componentⁱ: Unassembled WGS sequence

Keywords - Cellular componentⁱ

NucleusUniRule annotationARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSCPOG00000000168, Expressed in liver and 5 other tissues

Bgeeⁱ

ENSCPOG00000000168, Expressed in liver and 5 other tissues

Interactionⁱ

GO - Molecular functionⁱ

DNA binding domain binding Source: Ensembl
enzyme binding Source: Ensembl
identical protein binding Source: Ensembl
LBD domain binding Source: Ensembl
nuclear receptor binding Source: Ensembl
vitamin D receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10141.ENSCPOP00000000147

STRINGⁱ

10141.ENSCPOP00000000147

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	129 – 204	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	224 – 455	NR LBDInterPro annotationAdd BLAST		232

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 104	DisorderedSequence analysisAdd BLAST		104
Regionⁱ	203 – 226	DisorderedSequence analysisAdd BLAST		24

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	1 – 20	PolarSequence analysisAdd BLAST	20
Compositional biasⁱ	36 – 60	PolarSequence analysisAdd BLAST	25
Compositional biasⁱ	68 – 100	PolarSequence analysisAdd BLAST	33
Compositional biasⁱ	203 – 219	PolyampholyteSequence analysisAdd BLAST	17

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotation

Keywords - Domainⁱ

Zinc-fingerUniRule annotationARBA annotation

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159789
HOGENOMⁱ	CLU_007368_5_4_1
InParanoidⁱ	H0UTB8
TreeFamⁱ	TF352097

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

H0UTB8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
WDFSTQVNSS SLNSPTGRGS MAAPSLHPAL GPSIGSSLGS PGQLHSPIST 
        60         70         80         90        100
LSSPINGMGP PFSVISSPMG PHSMSVPTTP TLGFGTGSPQ LSSPMNPVSS 
       110        120        130        140        150
SEDIKPPLGL NGVLKVPAHP SGNMASFTKH ICAICGDRSS GKHYGVYSCE 
       160        170        180        190        200
GCKGFFKRTV RKDLTYTCRD NKDCLIDKRQ RNRCQYCRYQ KCLAMGMKRE 
       210        220        230        240        250
AVQEERQRGK DRSESEVEST SSANEDMPVE KILEAELAVE PKTETYVEAN 
       260        270        280        290        300
MGLSPSSPND PVTNICQAAD KQLFTLVEWA KRVPHFSELP LDDQVILLRA 
       310        320        330        340        350
GWNELLIASF SHRSIAVKDG ILLATGLHVH RNSAHSAGVG AIFDRVLTEL 
       360        370        380        390        400
VSKMRDMQMD KTELGCLRAI VLFNPDSKGL SNPAEVEALR EKVYASLEAY 
       410        420        430        440        450
CKHKYPEQPG RFAKLLLRLP ALRSIGLKCL EHLFFFKLIG DTPIDTFLME 

MLEAPHQMT

Length:459

Mass (Da):50,220

Last modified:November 22, 2017 - v2

Checksum:ⁱ5307A39DA0672534

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A286XC81	A0A286XC81_CAVPO		Uncharacterized protein Uncharacterized protein	RXRA	439	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAKN02024184 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AAKN02024184 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENSCPOT00000000169; ENSCPOP00000000147; ENSCPOG00000000168

Ensemblⁱ

ENSCPOT00000000169; ENSCPOP00000000147; ENSCPOG00000000168

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
H0UTB8	Uncharacterized protein		CAVPO		439	UniRef100_H0UTB8
+1

Protein	Similar proteins		Species	Score	Length	Source
H0UTB8	Retinoid X receptor alpha		BOVIN		467	UniRef90_F1MX52
Uncharacterized protein		BOBOX		467
Retinoid X receptor alpha		CANLF		556
retinoic acid receptor RXR-alpha isoform X2		VULVU		365
RXRA protein (Fragment)		CROCR		483
+54

Protein	Similar proteins		Species	Score	Length	Source
H0UTB8	Retinoid X receptor alpha		BOVIN		467	UniRef50_F1MX52
Uncharacterized protein		BOBOX		467
Retinoid X receptor alpha		CANLF		556
retinoic acid receptor RXR-alpha isoform X2		VULVU		365
RXRA protein (Fragment)		CROCR		483
+184

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAKN02024184 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AAKN02024184 Genomic DNA No translation available.

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

STRINGⁱ	10141.ENSCPOP00000000147

STRINGⁱ

10141.ENSCPOP00000000147

Genome annotation databases

Ensemblⁱ	ENSCPOT00000000169; ENSCPOP00000000147; ENSCPOG00000000168

Ensemblⁱ

ENSCPOT00000000169; ENSCPOP00000000147; ENSCPOG00000000168

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
GeneTreeⁱ	ENSGT00940000159789
HOGENOMⁱ	CLU_007368_5_4_1
InParanoidⁱ	H0UTB8
TreeFamⁱ	TF352097

Gene expression databases

Bgeeⁱ	ENSCPOG00000000168, Expressed in liver and 5 other tissues

Bgeeⁱ

ENSCPOG00000000168, Expressed in liver and 5 other tissues

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H0UTB8_CAVPO
Accessionⁱ	H0UTB8Primary (citable) accession number: H0UTB8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 22, 2012
	Last sequence update:	November 22, 2017
	Last modified:	October 7, 2020
	This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H0UTB8 (H0UTB8_CAVPO)

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Uncharacterized protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ