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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Sinorhizobium meliloti CCNWSX0020
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
ORF Names:SM0020_13782Imported
OrganismiSinorhizobium meliloti CCNWSX0020Imported
Taxonomic identifieri1107881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000004038 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 49HelicalUniRule annotationAdd BLAST23
Transmembranei69 – 90HelicalUniRule annotationAdd BLAST22
Transmembranei96 – 114HelicalUniRule annotationAdd BLAST19
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei174 – 193HelicalUniRule annotationAdd BLAST20
Transmembranei205 – 225HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 262HelicalUniRule annotationAdd BLAST18
Transmembranei269 – 288HelicalUniRule annotationAdd BLAST20
Transmembranei294 – 317HelicalUniRule annotationAdd BLAST24
Transmembranei344 – 363HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Structurei

3D structure databases

ProteinModelPortaliH0FZX2
SMRiH0FZX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

H0FZX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIWLVELAD HFQFFNLFRY ITFRTGAALF TSALIVFLFG PAMIASLRIR
60 70 80 90 100
QGKGQPIRAD GPQTHFKKAG TPTMGGLMIL TGIVVSSLLW ADLSSIYVVS
110 120 130 140 150
TLLVTLGFGA IGFYDDYLKV TKQSEKGFSG KARLGIEFVI AAVAVFFMMQ
160 170 180 190 200
AALSAGAAGS TFGSSVTFPF FKDLMLNLGY FFVLFGGFVI VGAGNSVNLT
210 220 230 240 250
DGLDGLAIVP VMIASAAFGL IAYLAGNAVF ANYLQIHFVP GTGELAVILG
260 270 280 290 300
AVIGAGLGFL WFNAPPAAIF MGDTGSLALG GLIGTVAVAT KHEIVMIIIG
310 320 330 340 350
GLFVIETLSV IIQVFWFKRT GHRVFLMAPI HHHFEKKGWT ESQVVIRFWI
360
IAVILAMVGL STLKLR
Length:366
Mass (Da):39,266
Last modified:February 22, 2012 - v1
Checksum:iF42FB33AAB5491CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGVV01000023 Genomic DNA Translation: EHK77365.1
RefSeqiWP_003529135.1, NZ_AGVV01000023.1

Genome annotation databases

EnsemblBacteriaiEHK77365; EHK77365; SM0020_13782
PATRICifig|1107881.3.peg.2796

Entry informationi

Entry nameiH0FZX2_RHIML
AccessioniPrimary (citable) accession number: H0FZX2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: May 23, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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