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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Leucoraja erinacea (Little skate) (Raja erinacea)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processElectron transport, Respiratory chainSAAS annotation, Transport
LigandNADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:ND5Imported
Encoded oniMitochondrionImported
OrganismiLeucoraja erinacea (Little skate) (Raja erinacea)Imported
Taxonomic identifieri7782 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaRajiformesRajidaeLeucoraja

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Transmembranei44 – 60HelicalSequence analysisAdd BLAST17
Transmembranei89 – 110HelicalSequence analysisAdd BLAST22
Transmembranei122 – 139HelicalSequence analysisAdd BLAST18
Transmembranei145 – 164HelicalSequence analysisAdd BLAST20
Transmembranei176 – 195HelicalSequence analysisAdd BLAST20
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei279 – 300HelicalSequence analysisAdd BLAST22
Transmembranei307 – 325HelicalSequence analysisAdd BLAST19
Transmembranei331 – 350HelicalSequence analysisAdd BLAST20
Transmembranei371 – 392HelicalSequence analysisAdd BLAST22
Transmembranei412 – 434HelicalSequence analysisAdd BLAST23
Transmembranei463 – 479HelicalSequence analysisAdd BLAST17
Transmembranei485 – 508HelicalSequence analysisAdd BLAST24
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 126Proton_antipo_NInterPro annotationAdd BLAST57
Domaini139 – 422Proton_antipo_MInterPro annotationAdd BLAST284
Domaini428 – 610NADH5_CInterPro annotationAdd BLAST183

Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR010934 NADH_DH_su5_C
IPR003945 NADHpl_OxRdtase_5
IPR018393 NADHpl_OxRdtase_5_subgr
IPR001750 ND/Mrp_mem
IPR001516 Proton_antipo_N
PfamiView protein in Pfam
PF06455 NADH5_C, 1 hit
PF00361 Proton_antipo_M, 1 hit
PF00662 Proton_antipo_N, 1 hit
PRINTSiPR01435 NPOXDRDTASE5
TIGRFAMsiTIGR01974 NDH_I_L, 1 hit

Sequencei

Sequence statusi: Complete.

G9L9I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSIIFNSSF LLIFIILLYP LFLSITSPQE SVSPNWASTH VKTAVKLSFF
60 70 80 90 100
ISLIPLFLFL DQGVESITTN WNWINLGPMN ITMSFKFDLY SIIFTPVALY
110 120 130 140 150
VTWSILEFAL WYMHTDPNFN RFFKYLLLFL MTMVILITAN NLFQLFIGWE
160 170 180 190 200
GVGIMSFLLI GWWYSRADAN TAALQAVIYN RIGDIGLILS MAWLAMNLNS
210 220 230 240 250
WETQQMFILS KNTDLTLPLL GLVLAAAGKS AQFGLHPWLP SAMEGPTPVS
260 270 280 290 300
ALLHSSTMVV AGVFLLIRLH PLIQDNQLIL SACLCLGALT TLFTATCALT
310 320 330 340 350
QNDIKKIVAF STSSQLGLMM VTIGLNQPQL AFLHICTHAF FKAMLFLCSG
360 370 380 390 400
SIIHSLDNEQ DIRKMGGLHK LLPFTASSLT VGSLALTGMP FLSGFFSKDA
410 420 430 440 450
IIEAMNTSNL NAWALTMTLL ATSFTAIYSL RLIFFTLMNS PRFTPLAPIN
460 470 480 490 500
ENNPLVLKPI KRLAYGSILA GLIITFNMTP TKTQILTMPL TLKLSALLVT
510 520 530 540 550
IIGLLLALEL TNLTKHQFKT HPTMLAHNFS NMLGYFPPIF HRLYPQINLH
560 570 580 590 600
WAQTISTHLI DLTWNEKMGP KNKLVQQTSM IKLFTLPQQG FIKIYLMIFF
610
LTLTLATLIM I
Length:611
Mass (Da):68,469
Last modified:February 22, 2012 - v1
Checksum:i05CFC04F80045011
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ034406 Genomic DNA Translation: AET87639.1
RefSeqiYP_004935528.1, NC_016429.1

Genome annotation databases

GeneIDi11452188

Similar proteinsi

Entry informationi

Entry nameiG9L9I9_LEUER
AccessioniPrimary (citable) accession number: G9L9I9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 7, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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