UniProtKB - G9BWQ0 (G9BWQ0_PIG)
Protein
Mothers against decapentaplegic homolog
Gene
SMAD2
Organism
Sus scrofa (Pig)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
- transforming growth factor beta receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mothers against decapentaplegic homologUniRule annotationShort name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation |
Gene namesi | |
Organismi | Sus scrofa (Pig)Imported |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:98329, SMAD2 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: InterPro
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 146 | MH1InterPro annotationAdd BLAST | 137 | |
Domaini | 244 – 437 | MH2InterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 177 – 221 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 199 – 221 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3701, Eukaryota |
GeneTreei | ENSGT00940000153499 |
HOGENOMi | CLU_026736_0_0_1 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 2 hits |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
G9BWQ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK
60 70 80 90 100
KLKKTGRLDE LEKAITTQNC NTKCVTIPRS LDGRLQVSHR KGLPHVIYCR
110 120 130 140 150
LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV
160 170 180 190 200
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG
210 220 230 240 250
ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY
260 270 280 290 300
ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR
310 320 330 340 350
HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC
360 370 380 390 400
NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT
410 420 430
VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A287BE69 | A0A287BE69_PIG | Mothers against decapentaplegic hom... | SMAD2 | 472 | Annotation score: | ||
A0A287AE86 | A0A287AE86_PIG | Mothers against decapentaplegic hom... | SMAD2 | 467 | Annotation score: | ||
F1RPR3 | F1RPR3_PIG | Mothers against decapentaplegic hom... | SMAD2 | 419 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEMK02000004 Genomic DNA No translation available. HQ687752 mRNA Translation: AEV40676.1 |
RefSeqi | NP_001243077.1, NM_001256148.1 XP_005659506.1, XM_005659449.2 |
Genome annotation databases
Ensembli | ENSSSCT00000042255; ENSSSCP00000037806; ENSSSCG00000004505 |
GeneIDi | 100155304 |
KEGGi | ssc:100155304 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEMK02000004 Genomic DNA No translation available. HQ687752 mRNA Translation: AEV40676.1 |
RefSeqi | NP_001243077.1, NM_001256148.1 XP_005659506.1, XM_005659449.2 |
3D structure databases
SMRi | G9BWQ0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000004860 |
Genome annotation databases
Ensembli | ENSSSCT00000042255; ENSSSCP00000037806; ENSSSCG00000004505 |
GeneIDi | 100155304 |
KEGGi | ssc:100155304 |
Organism-specific databases
CTDi | 4087 |
VGNCi | VGNC:98329, SMAD2 |
Phylogenomic databases
eggNOGi | KOG3701, Eukaryota |
GeneTreei | ENSGT00940000153499 |
HOGENOMi | CLU_026736_0_0_1 |
Gene expression databases
ExpressionAtlasi | G9BWQ0, baseline and differential |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 2 hits |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G9BWQ0_PIG | |
Accessioni | G9BWQ0Primary (citable) accession number: G9BWQ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |