UniProtKB - G9BWQ0 (G9BWQ0_PIG)

BLAST

>tr|G9BWQ0|G9BWQ0_PIG Mothers against decapentaplegic homolog OS=Sus scrofa OX=9823 GN=Smad2 PE=2 SV=1
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
LEKAITTQNCNTKCVTIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCE
YAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGI
EPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSE
PAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRR
HIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEF
AALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLD
KVLTQMGSPSVRCSSMS

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History
Entry version 55 (10 Oct 2018)
Sequence version 1 (22 Feb 2012)
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Protein

Mothers against decapentaplegic homolog

Gene

Smad2

Organism

Sus scrofa (Pig)

Status

Unreviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-KW
transforming growth factor beta receptor signaling pathway Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotation
Biological process	Transcription, Transcription regulationUniRule annotationSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-SSC-1181150 Signaling by NODAL R-SSC-1502540 Signaling by Activin R-SSC-2173788 Downregulation of TGF-beta receptor signaling R-SSC-2173789 TGF-beta receptor signaling activates SMADs R-SSC-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-SSC-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-SSC-5689880 Ub-specific processing proteases

Reactomeⁱ

R-SSC-1181150 Signaling by NODAL
R-SSC-1502540 Signaling by Activin
R-SSC-2173788 Downregulation of TGF-beta receptor signaling
R-SSC-2173789 TGF-beta receptor signaling activates SMADs
R-SSC-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-SSC-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-SSC-5689880 Ub-specific processing proteases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mothers against decapentaplegic homologUniRule annotation Short name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation
Gene namesⁱ	Name:Smad2Imported Synonyms:SMAD2Imported
Organismⁱ	Sus scrofa (Pig)Imported
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000008227 Componentⁱ: Chromosome 1

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	G9BWQ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 146	MH1InterPro annotationAdd BLAST		137
Domainⁱ	244 – 437	MH2InterPro annotationAdd BLAST		194

Sequence similaritiesⁱ

Belongs to the dwarfin/SMAD family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119091
KEGG Orthology (KO) More...KOⁱ	K04500
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G082C

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

G9BWQ0-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK 
        60         70         80         90        100
KLKKTGRLDE LEKAITTQNC NTKCVTIPRS LDGRLQVSHR KGLPHVIYCR 
       110        120        130        140        150
LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 
       160        170        180        190        200
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG 
       210        220        230        240        250
ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY 
       260        270        280        290        300
ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR 
       310        320        330        340        350
HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC 
       360        370        380        390        400
NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT 
       410        420        430 
VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS

Length:437

Mass (Da):48,956

Last modified:February 22, 2012 - v1

Checksum:ⁱ0E2FF38B009D2F9E

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A287AE86	A0A287AE86_PIG	Mothers against decapentaplegic hom... Mothers against decapentaplegic homolog, MAD homolog, Mothers against DPP homolog (SMAD family member)	SMAD2	467	Annotation score:
F1RPR3	F1RPR3_PIG	Uncharacterized protein Uncharacterized protein	SMAD2	227	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AEMK02000004 Genomic DNA No translation available. HQ687752 mRNA Translation: AEV40676.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001243077.1, NM_001256148.1 XP_005659506.1, XM_005659449.2
UniGeneⁱ	Ssc.101851 Ssc.45636

Genome annotation databases

Ensemblⁱ	ENSSSCT00000054452; ENSSSCP00000054408; ENSSSCG00000004505
GeneIDⁱ	100155304
KEGGⁱ	ssc:100155304

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
G9BWQ0	Isoform Short of Mothers against decapentaplegic homolog 2		HUMAN		437	UniRef100_Q15796-2
Mothers against decapentaplegic homolog		PAPAN		472
Mothers against decapentaplegic homolog		CALJA		437
Mothers against decapentaplegic homolog		PANTR		437
Mothers against decapentaplegic homolog		BOVIN		437
+21

Protein	Similar proteins		Species	Score	Length	Source
G9BWQ0	Isoform Short of Mothers against decapentaplegic homolog 2		HUMAN		437	UniRef90_Q15796-2
Mothers against decapentaplegic homolog		PAPAN		472
Mothers against decapentaplegic homolog		CALJA		437
Mothers against decapentaplegic homolog		PANTR		437
Mothers against decapentaplegic homolog		BOVIN		437
+133

Protein	Similar proteins		Species	Score	Length	Source
G9BWQ0	Isoform Short of Mothers against decapentaplegic homolog 2		HUMAN		437	UniRef50_Q15796-2
Mothers against decapentaplegic homolog		PAPAN		472
Mothers against decapentaplegic homolog		CALJA		437
Mothers against decapentaplegic homolog		PANTR		437
Mothers against decapentaplegic homolog		BOVIN		437
+235

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AEMK02000004 Genomic DNA No translation available. HQ687752 mRNA Translation: AEV40676.1
RefSeqⁱ	NP_001243077.1, NM_001256148.1 XP_005659506.1, XM_005659449.2
UniGeneⁱ	Ssc.101851 Ssc.45636

3D structure databases

ProteinModelPortalⁱ	G9BWQ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSSSCT00000054452; ENSSSCP00000054408; ENSSSCG00000004505
GeneIDⁱ	100155304
KEGGⁱ	ssc:100155304

Organism-specific databases

CTDⁱ	4087

CTDⁱ

4087

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
GeneTreeⁱ	ENSGT00760000119091
KOⁱ	K04500
OrthoDBⁱ	EOG091G082C

Enzyme and pathway databases

Reactomeⁱ	R-SSC-1181150 Signaling by NODAL R-SSC-1502540 Signaling by Activin R-SSC-2173788 Downregulation of TGF-beta receptor signaling R-SSC-2173789 TGF-beta receptor signaling activates SMADs R-SSC-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-SSC-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-SSC-5689880 Ub-specific processing proteases

Reactomeⁱ

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G9BWQ0_PIG
Accessionⁱ	G9BWQ0Primary (citable) accession number: G9BWQ0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 22, 2012
	Last sequence update:	February 22, 2012
	Last modified:	October 10, 2018
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

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UniParc

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UniProtKB - G9BWQ0 (G9BWQ0_PIG)

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Mothers against decapentaplegic homolog

Smad2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ