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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Rhizobium fredii (strain HH103) (Sinorhizobium fredii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126Substrate; in homodimeric partnerUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1
Binding sitei180SubstrateUniRule annotation1
Metal bindingi204Magnesium; via carbamate groupUniRule annotation1
Metal bindingi206MagnesiumUniRule annotation1
Metal bindingi207MagnesiumUniRule annotation1
Active sitei296Proton acceptorUniRule annotation1
Binding sitei297SubstrateUniRule annotation1
Binding sitei329SubstrateUniRule annotation1
Sitei336Transition state stabilizerUniRule annotation1
Binding sitei381SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase
Biological processCalvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotationImported
Ordered Locus Names:SFHH103_05883Imported
Encoded oniPlasmid pSfHH103eImported
OrganismiRhizobium fredii (strain HH103) (Sinorhizobium fredii)Imported
Taxonomic identifieri1117943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000007735 Componenti: Plasmid pSfHH103e

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 147RuBisCO_large_NInterPro annotationAdd BLAST121
Domaini157 – 464RuBisCO_largeInterPro annotationAdd BLAST308

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

KOiK01601
OMAiHRAMHAA
OrthoDBiPOG091H14UZ

Family and domain databases

CDDicd08212 RuBisCO_large_I, 1 hit
Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01338 RuBisCO_L_type1, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR020878 RuBisCo_large_chain_AS
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
IPR020888 RuBisCO_lsuI
PANTHERiPTHR42704 PTHR42704, 1 hit
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit
PROSITEiView protein in PROSITE
PS00157 RUBISCO_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

G9AH13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNADAKTEIK GKERYRAGVL KYAQMGYWNG DYEPKDTDLI ALFRITPQEG
60 70 80 90 100
VDPIEAAAAV AGESSTATWT VVWTDRLTAC DQYRAKAYRV DPVPGTPGQY
110 120 130 140 150
FCYVAYDLIL FEEGSIANLT ASIIGNVFSF KPLKAARLED MRLPVAYVKT
160 170 180 190 200
FKGPPTGIVV ERERLDKFGK PLLGATTKPK LGLSGKNYGR VVYEGLKGGL
210 220 230 240 250
DFMKDDENIN SQPFMHWRDR YLYCMDAVNH ASAVTGEVKG HYLNITAGTM
260 270 280 290 300
EEMYRRAEFA KELGSVIVMV DLIIGWTAIQ SISEWCRQND MILHMHRAGH
310 320 330 340 350
GTYTRQKNHG ISFRVIAKWL RLAGVDHLHA GTAVGKLEGD PMTVQGYYNV
360 370 380 390 400
CREMRNKIDL PRGLFFEQDW ADIKKVMPVA SGGIHAGQMH QLLDLFGDDV
410 420 430 440 450
VLQFGGGTIG HPMGIQAGAT ANRVALEAMV LARNEGRDIA HEGPEILRAA
460 470 480
AKWCKPLEAA LDTWGNISFN YTPTDSSDFV PSVSVA
Length:486
Mass (Da):53,841
Last modified:February 22, 2012 - v1
Checksum:i12A5226E9AF838A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE616899 Genomic DNA Translation: CCF00345.1
RefSeqiWP_014331997.1, NC_016815.1

Genome annotation databases

GeneIDi34338204
KEGGisfh:SFHH103_05883
PATRICifig|380.5.peg.5439

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE616899 Genomic DNA Translation: CCF00345.1
RefSeqiWP_014331997.1, NC_016815.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi34338204
KEGGisfh:SFHH103_05883
PATRICifig|380.5.peg.5439

Phylogenomic databases

KOiK01601
OMAiHRAMHAA
OrthoDBiPOG091H14UZ

Family and domain databases

CDDicd08212 RuBisCO_large_I, 1 hit
Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01338 RuBisCO_L_type1, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR020878 RuBisCo_large_chain_AS
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
IPR020888 RuBisCO_lsuI
PANTHERiPTHR42704 PTHR42704, 1 hit
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit
PROSITEiView protein in PROSITE
PS00157 RUBISCO_LARGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG9AH13_RHIFH
AccessioniPrimary (citable) accession number: G9AH13
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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