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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase

Gene

dapD

Organism
Pediococcus claussenii (strain ATCC BAA-344 / DSM 14800 / JCM 18046 / KCTC 3811 / P06)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.UniRule annotationSAAS annotation

Catalytic activityi

Acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + L-2-acetamido-6-oxoheptanedioate.UniRule annotationSAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route).UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase (dapD)
  2. no protein annotated in this organism
  3. N-acetyldiaminopimelate deacetylase (PECL_149)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPCLA701521:G1H20-144-MONOMER
UniPathwayiUPA00034; UER00022

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferaseUniRule annotation (EC:2.3.1.89UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-acetyltransferaseUniRule annotation
Short name:
THP acetyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate acetylaseUniRule annotation
Gene namesi
Name:dapDImported
Synonyms:dapHUniRule annotation
Ordered Locus Names:PECL_150Imported
OrganismiPediococcus claussenii (strain ATCC BAA-344 / DSM 14800 / JCM 18046 / KCTC 3811 / P06)Imported
Taxonomic identifieri701521 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
Proteomesi
  • UP000005444 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi701521.PECL_150

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86DapH_NInterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. DapH subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DMJ Bacteria
COG2171 LUCA
KOiK05822
OMAiNNAVIMM
OrthoDBiPOG091H0G02

Family and domain databases

HAMAPiMF_01691 DapH, 1 hit
InterProiView protein in InterPro
IPR019873 DapH
IPR013710 DapH_N
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF08503 DapH_N, 1 hit
PF00132 Hexapep, 2 hits
PF14602 Hexapep_2, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR03532 DapD_Ac, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

G8PEU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLDAESII NQIATSKKQT PVKAFLSGSK LYQLEIPSSI EAFIEQHSGV
60 70 80 90 100
IFGDWNDVKA FLKNPLIEHY HIENTARNSA VPLLDLKEIN ARIEPGAIIR
110 120 130 140 150
NQVLIGDNAV IMMGAIINIG AEIGDNTMID MGVVLGGRAL VGKNCHIGAG
160 170 180 190 200
AVLAGVVEPA SATPVQIDDN VLVGANAVVI EGVHVGEGAV VAAGSIVTKD
210 220 230
VPAHSVVAGV PARVVKMVDE QTSQKTALEE GLRNL
Length:235
Mass (Da):24,636
Last modified:February 22, 2012 - v1
Checksum:i79DDC928CB3B073E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003137 Genomic DNA Translation: AEV94474.1
RefSeqiWP_014214672.1, NC_016605.1

Genome annotation databases

EnsemblBacteriaiAEV94474; AEV94474; PECL_150
KEGGipce:PECL_150
PATRICifig|701521.8.peg.141

Similar proteinsi

Entry informationi

Entry nameiG8PEU4_PEDCP
AccessioniPrimary (citable) accession number: G8PEU4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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