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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Geobacillus thermoleovorans CCB_US3_UF5
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.SAAS annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotationSAAS annotation (EC:2.4.2.17UniRule annotationSAAS annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
ORF Names:GTCCBUS3UF5_34480Imported
OrganismiGeobacillus thermoleovorans CCB_US3_UF5Imported
Taxonomic identifieri1111068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000005636 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 202HisGInterPro annotationAdd BLAST151

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.UniRule annotation

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.SAAS annotation

Phylogenomic databases

KOiK00765
OrthoDBiPOG091H05D7

Family and domain databases

CDDicd13595 PBP2_HisGs, 1 hit
HAMAPiMF_01018 HisG_Short, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR024893 ATP_PRibTrfase_HisG_short
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit

Sequencei

Sequence statusi: Complete.

G8MX26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLTIAMPKG RIFEEAVELL RRADYALPPE FTESRKLVID VPEENMRFIL
60 70 80 90 100
AKPMDVVTYV EHGVADLGIA GKDVLMEEER DVYELLDLHI SRCHLAVAGL
110 120 130 140 150
PGAKMNEIAP RVATKYPNIA STYFREQGEQ VEIIRLNGSI ELAPLIGLAD
160 170 180 190 200
RIVDIVSTGR TLRENGLVEL ERIAEVTSRL IVNPASYRLN GGDIERLVDR

LAAVIPQP
Length:208
Mass (Da):23,201
Last modified:February 22, 2012 - v1
Checksum:iF15ECABAA34C5F3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003125 Genomic DNA Translation: AEV20749.1

Genome annotation databases

EnsemblBacteriaiAEV20749; AEV20749; GTCCBUS3UF5_34480
KEGGigte:GTCCBUS3UF5_34480
PATRICifig|1111068.3.peg.3355

Similar proteinsi

Entry informationi

Entry nameiG8MX26_GEOTH
AccessioniPrimary (citable) accession number: G8MX26
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 27, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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