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Protein

Imidazole glycerol phosphate synthase subunit HisF

Gene

hisF

Organism
Geobacillus thermoleovorans CCB_US3_UF5
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.UniRule annotationSAAS annotation

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11UniRule annotation1
Active sitei130UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00010

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisFUniRule annotation (EC:4.1.3.-UniRule annotation)
Alternative name(s):
IGP synthase cyclase subunitUniRule annotation
IGP synthase subunit HisFUniRule annotation
ImGP synthase subunit HisFUniRule annotation
Short name:
IGPS subunit HisFUniRule annotation
Gene namesi
Name:hisFUniRule annotation
ORF Names:GTCCBUS3UF5_34420Imported
OrganismiGeobacillus thermoleovorans CCB_US3_UF5Imported
Taxonomic identifieri1111068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000005636 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliG8MX20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK02500
OrthoDBiPOG091H06EY

Family and domain databases

CDDicd04731 HisF, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01013 HisF, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR004651 HisF
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00735 hisF, 1 hit

Sequencei

Sequence statusi: Complete.

G8MX20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITKRIIPCL DVKDGRVVKG VQFVQLRDAG DPVELAKAYD EQGADELVFL
60 70 80 90 100
DISASHEGRK TMVDVVERVA AQLAIPFTVG GGIHSLEDMK RMLRAGADKV
110 120 130 140 150
SLNTAAVLHP TLITEGADFF GSQCIVVAID AKYDETLGSW RVYTHGGRNA
160 170 180 190 200
TNWEVVAWAQ EAVRLGAGEI LLTSMDADGG KNGFDIELTR RVSEAVPIPV
210 220 230 240 250
IASGGAGKAE HFLEAFEKGK ADAALAASIF HYKETSVGQV KAYLKEKGVN

VR
Length:252
Mass (Da):27,097
Last modified:February 22, 2012 - v1
Checksum:i7F7FE3DF32987E04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003125 Genomic DNA Translation: AEV20743.1
RefSeqiWP_014196727.1, NC_016593.1

Genome annotation databases

EnsemblBacteriaiAEV20743; AEV20743; GTCCBUS3UF5_34420
KEGGigte:GTCCBUS3UF5_34420
PATRICifig|1111068.3.peg.3350

Similar proteinsi

Entry informationi

Entry nameiG8MX20_GEOTH
AccessioniPrimary (citable) accession number: G8MX20
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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