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Entry version 46 (02 Jun 2021)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Cellobiohydrolase A (1,4-beta-cellobiosidase A)

Gene

Clocl_4212

Organism
Hungateiclostridium clariflavum (strain DSM 19732 / NBRC 101661 / EBR45) (Clostridium clariflavum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CCLA720554:G1H1U-4150-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cellobiohydrolase A (1,4-beta-cellobiosidase A)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Clocl_4212Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHungateiclostridium clariflavum (strain DSM 19732 / NBRC 101661 / EBR45) (Clostridium clariflavum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri720554 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaEubacterialesOscillospiraceaeAcetivibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005435 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500351156731 – 1001Sequence analysisAdd BLAST971

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
720554.Clocl_4212

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 300CBM2InterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni168 – 199DisorderedSequence analysisAdd BLAST32
Regioni297 – 317DisorderedSequence analysisAdd BLAST21
Regioni454 – 473DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi302 – 316Pro residuesSequence analysisAdd BLAST15

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG5297, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_299519_0_0_9

Database of Orthologous Groups

More...
OrthoDBi
1331351at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001919, CBD2
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR012291, CBM2_carb-bd_dom_sf
IPR002102, Cohesin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00553, CBM_2, 1 hit
PF00963, Cohesin, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00637, CBD_II, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49384, SSF49384, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51173, CBM2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

G8LUJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYMSKFKRFI SVVLCAFLLC TLLPIEKAEA AGFTVSVESV SGSFGQQIVV
60 70 80 90 100
PVKFSNVPSN GIITADMTIT YDSSKLEYVS GEAGSIVTNP SINYAINKDK
110 120 130 140 150
DGSIKVLFLD DTLTSGYISR DGVFTNLTFK VISSASTTAT VTVNKANFGD
160 170 180 190 200
RNLSPITAQF SAGTITLNSG NSTIPTTQPT TPPWTQPTTP PQNSSGNFSV
210 220 230 240 250
NYSQNSWGTG ATVSMTITNN GSSAVNGWTV NFTFPGNQKI TNAWNCTYTQ
260 270 280 290 300
SGSSVTINNV DYNAVIPAGG SVTIGFNISY SGTNEAPTNF IVNSSSVNPG
310 320 330 340 350
NPTQPPFQPT LPPTSQPSTG PIVTGFTAYV ESVTASAGEQ VVVPIKLANV
360 370 380 390 400
PSNGITTADM TITYDASKLE YVKGEAGSIV INPSINFAIN KEKDGIIRIL
410 420 430 440 450
FLDDTLLNEY ISKDGVFANI TFKVSGTSTV TISKATFGDR SLKPVSATLT
460 470 480 490 500
AGTVTVGGGT TQPTPTPTQP TTGPIVTGFT AYVESVTASA GEQVVVPIKL
510 520 530 540 550
ANVPSNGITT ADMTITYDAS KLEYVKGEAG SIVINPSINF AINKEKDGII
560 570 580 590 600
RILFLDDTLL NEYISKDGVF ANITFKVSGT STVTISKATF GDRSLKPVSA
610 620 630 640 650
TLTAGTVTVG GGTTQPTVPP TSQPTTGPIV TGFTAYVESV TASAGEQVVV
660 670 680 690 700
PIKLANVPSN GITTADMTIT YDASKLEYVK GEAGSIVINP SINFAINKEK
710 720 730 740 750
DGIIRILFLD DTLLNEYISK DGVFANITFK VSGTSTVTIS KATFGDRSLK
760 770 780 790 800
PVSATLTAGT VTVGGGTTQP TPTPTQPTTG PIVTGFTAYV ESVTASAGGQ
810 820 830 840 850
VVVPIKLANV PSNGITTADM TITYDASKLE YVKGEAGSIV INPSINFAIN
860 870 880 890 900
KEKDGIIRIL FLDDTLLNEY ISKDGVFANI TFKVSGTSTV TISKATFGDR
910 920 930 940 950
SLKPVSATLT AGTVTVGGGT TQPTVPPTSQ PTTGPIVTGF TAYVESVTAS
960 970 980 990 1000
AGEQVVVPIK LANVPSNGIT TADMTITYDA SKLEYVKGEA GSIVINPYNK

L
Length:1,001
Mass (Da):104,291
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2699D90786AD4C4E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003065 Genomic DNA Translation: AEV70638.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AEV70638; AEV70638; Clocl_4212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ccl:Clocl_4212

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003065 Genomic DNA Translation: AEV70638.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi720554.Clocl_4212

Genome annotation databases

EnsemblBacteriaiAEV70638; AEV70638; Clocl_4212
KEGGiccl:Clocl_4212

Phylogenomic databases

eggNOGiCOG5297, Bacteria
HOGENOMiCLU_299519_0_0_9
OrthoDBi1331351at2

Enzyme and pathway databases

BioCyciCCLA720554:G1H1U-4150-MONOMER

Family and domain databases

Gene3Di2.60.40.290, 1 hit
InterProiView protein in InterPro
IPR001919, CBD2
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR012291, CBM2_carb-bd_dom_sf
IPR002102, Cohesin_dom
PfamiView protein in Pfam
PF00553, CBM_2, 1 hit
PF00963, Cohesin, 6 hits
SMARTiView protein in SMART
SM00637, CBD_II, 1 hit
SUPFAMiSSF49384, SSF49384, 7 hits
PROSITEiView protein in PROSITE
PS51173, CBM2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG8LUJ0_HUNCD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G8LUJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 2, 2021
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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