UniProtKB - G8JLM4 (G8JLM4_HUMAN)
Protein
Submitted name:
Usher syndrome type-1C protein-binding protein 1
Gene
USHBP1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Usher syndrome type-1C protein-binding protein 1Imported |
Gene namesi | Name:USHBP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24058, USHBP1 |
VEuPathDBi | HostDB:ENSG00000130307.11 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130307, Expressed in apex of heart and 136 other tissues |
ExpressionAtlasi | G8JLM4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 235 – 298 | MCC-bdg_PDZInterPro annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 74 – 108 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 164 – 192 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 332 – 352 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 476 – 519 | DisorderedSequence analysisAdd BLAST | 44 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 130 – 157 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 422 – 449 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 537 – 557 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 587 – 610 | Sequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 170 – 185 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 334 – 352 | PolarSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00530000063974 |
OMAi | APEMHIM |
Family and domain databases
InterProi | View protein in InterPro IPR040171, USBP1-like IPR019536, USH1C-bd_PDZ_domain |
PANTHERi | PTHR23347, PTHR23347, 1 hit |
Pfami | View protein in Pfam PF10506, MCC-bdg_PDZ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
G8JLM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLHPTDKKMD GGSGRELASA PEVPHKPAVE AHQAPEAALQ YKETVPPGNG
60 70 80 90 100
APDVFQTLQH TLSSLEAAAA AWRHQPPSHS GPMEFEGTSE GGAGSLGKQE
110 120 130 140 150
GAGSCQREAA RLAERNAWLR LALSSREDEL VRTQASLEAI RAEKETLQKE
160 170 180 190 200
VQELQDSLLR LEPCPHLSHN QAGGSGSGSS SSEADREPWE TQDSFSLAHP
210 220 230 240 250
LLRRLRSHSS TQILGSLPNQ PLSPEMHIME AQMEQLRGSI EKLKCFNRLL
260 270 280 290 300
SAVLQGYKGR CEGLSMQLGQ REAEATALHL ALQYSEHCEE AYRVLLALRE
310 320 330 340 350
ADSGAGDEAP MSDLQAAEKE AWRLLAQEEA AMDAGAQQNP QPSPEGSSVD
360 370 380 390 400
KPTPQEVAFQ LRSYVQRLQE RRSLMKILSE PGPTLAPMPT VPRAEAMVQA
410 420 430 440 450
ILGTQAGPAL PRLEKTQIQQ DLVAAREALA DLMLRLQLVR REKRGLELRE
460 470 480 490 500
AALRALGPAH VLLLEQLRWE RAELQAGGAN SSGGHSSGGG SSGDEEEWYQ
510 520 530 540 550
GLPAVPGGTS GIDGGQVGRA WDPEKLAQEL AASLTRTLDL QEQLQSLRRE
560 570 580 590 600
LEQVAQKGRA RRSQSAELNR DLCKAHSALV LAFRGAHRKQ EEQRRKLEQQ
610 620 630
MALMEAQQAE EVAVLEATAR ALGKPRPPLP PPQLGDTFL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8N6Y0 | USBP1_HUMAN | Usher syndrome type-1C protein-bind... | USHBP1 AIEBP, MCC2 | 703 | Annotation score: | ||
Q8N8Y1 | Q8N8Y1_HUMAN | Usher syndrome 1C binding protein 1... | USHBP1 hCG_37669 | 383 | Annotation score: | ||
M0R3B1 | M0R3B1_HUMAN | Usher syndrome type-1C protein-bind... | USHBP1 | 121 | Annotation score: | ||
M0R172 | M0R172_HUMAN | Usher syndrome type-1C protein-bind... | USHBP1 | 32 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010463 Genomic DNA No translation available. AC010646 Genomic DNA No translation available. AC104522 Genomic DNA No translation available. KF456520 Genomic DNA No translation available. |
RefSeqi | NP_001284632.1, NM_001297703.1 |
Genome annotation databases
Ensembli | ENST00000431146; ENSP00000407902; ENSG00000130307 |
GeneIDi | 83878 |
UCSCi | uc010xpk.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010463 Genomic DNA No translation available. AC010646 Genomic DNA No translation available. AC104522 Genomic DNA No translation available. KF456520 Genomic DNA No translation available. |
RefSeqi | NP_001284632.1, NM_001297703.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | G8JLM4 |
PRIDEi | G8JLM4 |
ProteomicsDBi | 34275 |
Protocols and materials databases
Antibodypediai | 65308, 35 antibodies |
DNASUi | 83878 |
Genome annotation databases
Ensembli | ENST00000431146; ENSP00000407902; ENSG00000130307 |
GeneIDi | 83878 |
UCSCi | uc010xpk.2, human |
Organism-specific databases
CTDi | 83878 |
HGNCi | HGNC:24058, USHBP1 |
OpenTargetsi | ENSG00000130307 |
VEuPathDBi | HostDB:ENSG00000130307.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000063974 |
OMAi | APEMHIM |
Miscellaneous databases
BioGRID-ORCSi | 83878, 17 hits in 987 CRISPR screens |
ChiTaRSi | USHBP1, human |
GenomeRNAii | 83878 |
Gene expression databases
Bgeei | ENSG00000130307, Expressed in apex of heart and 136 other tissues |
ExpressionAtlasi | G8JLM4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR040171, USBP1-like IPR019536, USH1C-bd_PDZ_domain |
PANTHERi | PTHR23347, PTHR23347, 1 hit |
Pfami | View protein in Pfam PF10506, MCC-bdg_PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G8JLM4_HUMAN | |
Accessioni | G8JLM4Primary (citable) accession number: G8JLM4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 25, 2012 |
Last sequence update: | January 25, 2012 | |
Last modified: | April 7, 2021 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |