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UniProtKB - G8JLB6 (G8JLB6_HUMAN)
Protein
Submitted name:
Heterogeneous nuclear ribonucleoprotein H
Gene
HNRNPH1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Heterogeneous nuclear ribonucleoprotein H |
Gene namesi | Name:HNRNPH1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5041, HNRNPH1 |
VEuPathDBi | HostDB:ENSG00000169045 |
Subcellular locationi
Nucleus
- nucleoplasm ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
PTM / Processingi
Keywords - PTMi
AcetylationARBA annotation, Isopeptide bondARBA annotation, Ubl conjugationARBA annotationProteomic databases
EPDi | G8JLB6 |
MaxQBi | G8JLB6 |
PRIDEi | G8JLB6 |
ProteomicsDBi | 34178 |
PTM databases
MetOSitei | G8JLB6 |
SwissPalmi | G8JLB6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169045, Expressed in left lobe of thyroid gland and 250 other tissues |
ExpressionAtlasi | G8JLB6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 90 | RRMInterPro annotationAdd BLAST | 80 | |
Domaini | 111 – 188 | RRMInterPro annotationAdd BLAST | 78 | |
Domaini | 289 – 364 | RRMInterPro annotationAdd BLAST | 76 |
Phylogenomic databases
GeneTreei | ENSGT00940000153503 |
OMAi | SANEQHI |
OrthoDBi | 603679at2759 |
PhylomeDBi | G8JLB6 |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR012996, Znf_CHHC |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF08080, zf-RNPHF, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 25 potential isoforms that are computationally mapped.Show allAlign All
G8JLB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440 450
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYGNQGAVN SSYYSSGSRA
460 470
SMGVNGMGGL SSMSSMSGGW GM
Computationally mapped potential isoform sequencesi
There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP31943 | HNRH1_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 HNRPH, HNRPH1 | 449 | Annotation score: | ||
E9PCY7 | E9PCY7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 429 | Annotation score: | ||
D6RIU0 | D6RIU0_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 168 | Annotation score: | ||
D6RBM0 | D6RBM0_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 212 | Annotation score: | ||
D6RFM3 | D6RFM3_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 163 | Annotation score: | ||
H0YBK1 | H0YBK1_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 117 | Annotation score: | ||
H0YBG7 | H0YBG7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 185 | Annotation score: | ||
H0YBD7 | H0YBD7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 194 | Annotation score: | ||
D6RIT2 | D6RIT2_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 164 | Annotation score: | ||
H0YB39 | H0YB39_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 277 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136604 Genomic DNA No translation available. |
RefSeqi | XP_005265952.1, XM_005265895.2 XP_005265953.1, XM_005265896.2 XP_011532844.1, XM_011534542.1 XP_011532846.1, XM_011534544.1 XP_011532847.1, XM_011534545.1 XP_011532848.1, XM_011534546.1 |
Genome annotation databases
Ensembli | ENST00000329433.10; ENSP00000327539.6; ENSG00000169045.17 |
UCSCi | uc021yjd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136604 Genomic DNA No translation available. |
RefSeqi | XP_005265952.1, XM_005265895.2 XP_005265953.1, XM_005265896.2 XP_011532844.1, XM_011534542.1 XP_011532846.1, XM_011534544.1 XP_011532847.1, XM_011534545.1 XP_011532848.1, XM_011534546.1 |
3D structure databases
SMRi | G8JLB6 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | G8JLB6, 4 interactors |
PTM databases
MetOSitei | G8JLB6 |
SwissPalmi | G8JLB6 |
Proteomic databases
EPDi | G8JLB6 |
MaxQBi | G8JLB6 |
PRIDEi | G8JLB6 |
ProteomicsDBi | 34178 |
Protocols and materials databases
Antibodypediai | 17692, 310 antibodies from 29 providers |
Genome annotation databases
Ensembli | ENST00000329433.10; ENSP00000327539.6; ENSG00000169045.17 |
UCSCi | uc021yjd.2, human |
Organism-specific databases
HGNCi | HGNC:5041, HNRNPH1 |
OpenTargetsi | ENSG00000169045 |
VEuPathDBi | HostDB:ENSG00000169045 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153503 |
OMAi | SANEQHI |
OrthoDBi | 603679at2759 |
PhylomeDBi | G8JLB6 |
Miscellaneous databases
BioGRID-ORCSi | 3187, 674 hits in 1094 CRISPR screens |
ChiTaRSi | HNRNPH1, human |
GenomeRNAii | 3187 |
Gene expression databases
Bgeei | ENSG00000169045, Expressed in left lobe of thyroid gland and 250 other tissues |
ExpressionAtlasi | G8JLB6, baseline and differential |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR012996, Znf_CHHC |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF08080, zf-RNPHF, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | G8JLB6_HUMAN | |
Accessioni | G8JLB6Primary (citable) accession number: G8JLB6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 25, 2012 |
Last sequence update: | January 25, 2012 | |
Last modified: | May 25, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |