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Protein
Submitted name:

Cyclin-A2

Gene

CCNA2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclinUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-1538133 G0 and Early G1
R-BTA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-BTA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-BTA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-BTA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-BTA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-BTA-5689880 Ub-specific processing proteases
R-BTA-5693607 Processing of DNA double-strand break ends
R-BTA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-BTA-6804756 Regulation of TP53 Activity through Phosphorylation
R-BTA-6804757 Regulation of TP53 Degradation
R-BTA-68911 G2 Phase
R-BTA-68949 Orc1 removal from chromatin
R-BTA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-BTA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-BTA-69563 p53-Dependent G1 DNA Damage Response
R-BTA-69656 Cyclin A:Cdk2-associated events at S phase entry

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin-A2Imported
Gene namesi
Name:CCNA2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:26957 CCNA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSBTAG00000004943

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 239Cyclin N-terminalInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the cyclin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
OMAiTMDISIV
OrthoDBiEOG091G090I
TreeFamiTF101002

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR032447 Cyclin-A_N
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
PF16500 Cyclin_N2, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

G8JKW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSSAHGPA AREAGSAVTL QQTAFQEDQE NVNPEKAAPA QQPRTRAGLA
60 70 80 90 100
VLRAGNSRGP APQRPKTRRV APLKDLPIND EYVPVPPWKA NNKQPAFTIH
110 120 130 140 150
VDEAEEIQKR PTESKKSESE DVLAFNSAVT LPGPRKPLAP LDYPMDGSFE
160 170 180 190 200
SPHTMEMSVV LEDEKPVSVN EVPDYHEDIH TYLREMEVKC KPKVGYMKKQ
210 220 230 240 250
PDITNSMRAI LVDWLVEVGE EYKLQNETLH LAVNYIDRFL SSMSVLRGKL
260 270 280 290 300
QLVGTAAMLL ASKFEEIYPP EVAEFVYITD DTYTKKQVLR MEHLVLKVLA
310 320 330 340 350
FDLAAPTINQ FLTQYFLHQQ PANCKVESLA MFLGELSLID ADPYLKYLPS
360 370 380 390 400
VIAAAAFHLA LYTVTGQSWP ESLVQKTGYT LETLKPCLLD LHQTYLRAPQ
410 420
HAQQSIREKY KNSKYHGVSL LNPPETLNV
Length:429
Mass (Da):48,133
Last modified:January 25, 2012 - v1
Checksum:i692C269C5FBC996C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02015230 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSBTAT00000006503; ENSBTAP00000006503; ENSBTAG00000004943

Similar proteinsi

Entry informationi

Entry nameiG8JKW1_BOVIN
AccessioniPrimary (citable) accession number: G8JKW1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: July 18, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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