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Entry version 47 (02 Jun 2021)
Sequence version 1 (25 Jan 2012)
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Protein
Submitted name:

Ryanodine receptor 1

Gene
N/A
Organism
Plutella xylostella (Diamondback moth) (Plutella maculipennis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, ReceptorImported
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.1.9, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlutella xylostella (Diamondback moth) (Plutella maculipennis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri51655 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaYponomeutoideaPlutellidaePlutella

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4466 – 4486HelicalSequence analysisAdd BLAST21
Transmembranei4649 – 4670HelicalSequence analysisAdd BLAST22
Transmembranei4731 – 4750HelicalSequence analysisAdd BLAST20
Transmembranei4917 – 4939HelicalSequence analysisAdd BLAST23
Transmembranei4993 – 5016HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 63Combined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G8EME3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 149MIRInterPro annotationAdd BLAST55
Domaini156 – 201MIRInterPro annotationAdd BLAST46
Domaini211 – 265MIRInterPro annotationAdd BLAST55
Domaini271 – 329MIRInterPro annotationAdd BLAST59
Domaini337 – 397MIRInterPro annotationAdd BLAST61
Domaini577 – 803B30.2/SPRYInterPro annotationAdd BLAST227
Domaini1032 – 1214B30.2/SPRYInterPro annotationAdd BLAST183
Domaini1466 – 1694B30.2/SPRYInterPro annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1353 – 1510DisorderedSequence analysisAdd BLAST158
Regioni2819 – 2840DisorderedSequence analysisAdd BLAST22
Regioni2930 – 2961DisorderedSequence analysisAdd BLAST32
Regioni3596 – 3622DisorderedSequence analysisAdd BLAST27
Regioni3867 – 3893DisorderedSequence analysisAdd BLAST27
Regioni4498 – 4522DisorderedSequence analysisAdd BLAST25
Regioni4543 – 4585DisorderedSequence analysisAdd BLAST43
Regioni4686 – 4710DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili460 – 480Sequence analysisAdd BLAST21
Coiled coili3803 – 3823Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1353 – 1371Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1385 – 1419Polar residuesSequence analysisAdd BLAST35
Compositional biasi1420 – 1459Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1478 – 1510Polar residuesSequence analysisAdd BLAST33
Compositional biasi2823 – 2840Polar residuesSequence analysisAdd BLAST18
Compositional biasi3870 – 3887Acidic residuesSequence analysisAdd BLAST18
Compositional biasi4549 – 4564Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G8EME3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFLEN
60 70 80 90 100
IQDKNIPPDL SQCVFVIEQA LSVRALQELV TAAGSETGKG TGSGHRTLLY
110 120 130 140 150
GNAILLRHLN SDMYLACLST SSSQDKLAFD VGLQEHSQGE ACWWTLHPAS
160 170 180 190 200
KQRSEGEKVR VGDDLILVSV ATERYLHTTK ENEVSIVNAS FHVTHWSVQP
210 220 230 240 250
YGTGISRMKY VGYVFGGDVL RFFHGGDECL TIPSSWSNEG QHNIVVYEGG
260 270 280 290 300
SVMSQARSLW RLELARTKWA GGFINWYHPM RIRHITTGRY LAVNDQNELY
310 320 330 340 350
LVSREEATTA SCAFCLRQEK DDQKVVLEDK DLEIIGAPII KYGDSTVIVQ
360 370 380 390 400
HSESSLWLSY KSYETKKKGL GKVEEKQAIL HEEGKMDGLD FSRSQEEESR
410 420 430 440 450
TARVIRKCSS LFTKFINGLE TLQENRRHSM FFATVNLAEM VMCLEDLINY
460 470 480 490 500
FAQPDEDMEH EEKQNKFRAL RNRQDLFQEE GILNLILEAI DKINVITSQG
510 520 530 540 550
FLAGFLAGDE CGQSWEMISA YLYQLLAAII KGNHTNCAQF ANSNRLNWLF
560 570 580 590 600
SRLGSQASGE GTGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
610 620 630 640 650
PKVLDVLCSL CVGNGVAVRS SQNNICDYLL PGKNLLLQTQ LVDHVSSVRP
660 670 680 690 700
NIFVGRVEGS AVYQKWYFEV TMDHIEKTTH MMPHLRIGWA NTTGYVPYPG
710 720 730 740 750
GGEKWGGNGV GDDLYSYGYD GAFLWSGGRK TGVNRTHAEE PYIRKGDVIG
760 770 780 790 800
CALDLTVPII NFMFNGVRVT GSFTNFNLEG MFFPVISCSS KLSCRFLLGG
810 820 830 840 850
EHGRLRYAAP EGYSPLVECL LPQQILSLEP CFCFGNLAKR ALSGPPLVQD
860 870 880 890 900
DTAFVPMPVD TLTITLPSYI EQIRDKLAEN IHEMWAMNKI EAGWMYGEHR
910 920 930 940 950
ENLHKIHPCL VPFERLPAAE KRYDIQLAVQ TLKTILALGY YISLDKPPAR
960 970 980 990 1000
IRNVRLPNEP FLQSNGYKPA PLDLSAVTLT PKMDELVEQL AENTHNLWAR
1010 1020 1030 1040 1050
ERIQQGWTYG LNEDSDMHRS PHLVPYPKVD EAIKKANRDT ASETVRTLLV
1060 1070 1080 1090 1100
YGYMLDPPTG EHEALLAEAS KMKQADFRTY RAEKNYAVNS GKWYFEFEIL
1110 1120 1130 1140 1150
TAGPMRVGWA HADMPPGMML GQDENSWAFD GYNEEKVYVN SSESFGKQWA
1160 1170 1180 1190 1200
VGDVVGVFLD LIDNTISFSL NGELLMDALG GETTFADVQG DNFVPACTLG
1210 1220 1230 1240 1250
VGRKARLTYG QDVNTLKYFT TCGLQEGYEP FCVNMKRDVT HWYTKDQPIF
1260 1270 1280 1290 1300
ENTDEMADTR IDVTRIPAGS ETPPCMKISH NTFETMEKAN WEFLRLSLPV
1310 1320 1330 1340 1350
ICHAEFIDEN EKARRWVEIK ERQQALMKEA AEAQMPAHID QIMRSGFTMN
1360 1370 1380 1390 1400
DIKGLHRDYD DGQEEPSNSK MKRLPSRPPR KGSLSRGVTI QNYSLQPGQQ
1410 1420 1430 1440 1450
NGMHRTASEM EMSKYESGAQ SVTDDKKDKR GRSPFKFFSR SKRGESGDRK
1460 1470 1480 1490 1500
SRKSKTPDPF SDAEVSPERA APRRPNPQIR VSQANQRYEK NQSRQNLYGS
1510 1520 1530 1540 1550
QGGGLNNGNT NLQVNTPPVE RKQMTGGALS GATTETVGNE IFDAECLKLI
1560 1570 1580 1590 1600
NEYFYGVRIF PGQDPTHVYI GWVTTQYHLH SKDFNQSKVT KSSVIITDDY
1610 1620 1630 1640 1650
DRVIRSVNRQ SCYMVRADEL YNEVMAEAVG KGASQGMFVG CSVDTSTGTV
1660 1670 1680 1690 1700
AFTCEGKETS FRFSMEPETK LFPAIFVEAT SKEILQIELG RSLHSLPLSA
1710 1720 1730 1740 1750
AVLPTSDKHV IPQFPPRLKV QCLKPHQWAR VPNQSLQVHA LKLSDIRGWS
1760 1770 1780 1790 1800
MLCEDAVSML ALHIPEEDRC IDILELIEMD KLLSFHSHTL TLYAALCYQS
1810 1820 1830 1840 1850
NYRAAHALCQ HVDQKQLLYA IQSQYMSGPL RQGFYDLLIA LHLESHATTM
1860 1870 1880 1890 1900
EVCKNEYVIP LGPELKALYE EPEMGHSLRS LQTESVRPMM KMTDIAESIN
1910 1920 1930 1940 1950
EISNLYSPYF PLEVVREFVM QALAEAVETN QVHNRDPVGG SNENLFLPLI
1960 1970 1980 1990 2000
KLVDRLLLVG MMRDEDVEKL LIMTNPETWD PTFDKEGKDE HKKGLLHMKM
2010 2020 2030 2040 2050
AEGAKLQMCY LLHHLNDIQL RHRVEAIIAF AHDFVGDLQA DQLRRYVEIK
2060 2070 2080 2090 2100
QSDLPSAVAA KKTREYRCPP REQMNAILSF KHLEEDDKEN IPCGEDLIAR
2110 2120 2130 2140 2150
MNDFHQALMA HVSLMALQEP EVEENPEALN KPGAIGKLYN IINTVKELDE
2160 2170 2180 2190 2200
EPKAIEEPVK KTPEEKFRKV LIQTIVSWAE ESQIETPKLV REMFSLLVRQ
2210 2220 2230 2240 2250
YDAVGELVRA LEKTYVINAK TKLDVAEMWV GLSQIRALLP VQMSQEEEEL
2260 2270 2280 2290 2300
MRKRLWKLVN NHTFFQHPDL IRVLRVHENV MAVMMNTLGR RAQAQSDATP
2310 2320 2330 2340 2350
NQPAAEEKDT SHEMVVACCR FPCYFCRTGR QNQKAMFDHF DFLLENSNIL
2360 2370 2380 2390 2400
LSRPSLRGST PLDVAYSSLM ENTELALALR EHYLEKIAVY LSRCGLQSNS
2410 2420 2430 2440 2450
ELVEKGYPDL GWDPVEGERY LDFLRFCVWV NGESVEENAN LVIRLLIRRP
2460 2470 2480 2490 2500
ECLGPALRGE GEGLLKAIVD ANKMSEKIAD RRKLHEEVGQ EDVAFSHPLP
2510 2520 2530 2540 2550
ESDEDEDYID TGAAILNFYC TLVDLLGRCA PDASVIALGK NESLRARAIL
2560 2570 2580 2590 2600
RSLVPLEDLQ GVLSLRFTLN NPAMGEERPK SDMPSGLIPG HKQSIVLFLE
2610 2620 2630 2640 2650
RVYGIETQEL FYRLLEEAFL PDLRAATMLD RNDGCESDMA LSMNRYIGNS
2660 2670 2680 2690 2700
ILPLLIKHAN FYNEAENYGS LLDATLHTVY RLSKNRMLTK GQREAVSDFL
2710 2720 2730 2740 2750
VALTSAMQPS HVAETAEETH GDVSKLSEYT TVALRLLTLH YERCAKYYGS
2760 2770 2780 2790 2800
TGGQGVYGAS SDEEKRLTMM LFSNIFDSLS KMDYEPELFG KALPCLIAIG
2810 2820 2830 2840 2850
CALPPDYSLS KNYDDEFYGK EQQTTGGPDN PQYNPQPINT SSVALNNDLN
2860 2870 2880 2890 2900
TIVQKFSEHY HDAWASRKIE NSWVYGENWS DSQKAHPRLK PYNMLNDYEK
2910 2920 2930 2940 2950
ERYKEPVRES LKALLAIGWS VEHSEVDIPS TNRSSMRRQS KSGGRPVDVV
2960 2970 2980 2990 3000
TDSATPFNYN PHPVDMTNLT LSREMQNMAE RLAENAHDIW AKKKKEELTV
3010 3020 3030 3040 3050
NGGGIHPQLV PYDLLTDKEK KKDRERSQEF LKYLQYQGYK LHRPSKATQS
3060 3070 3080 3090 3100
ETEQTATGVA IELRFAYSLL EKLIQYIDRA TINMKMLKPS TTFSRRSSFK
3110 3120 3130 3140 3150
TSTRDIKFFS KVVLPLMEKY FSTHRNYFIA VATATNNVGA ASLKEKEMVA
3160 3170 3180 3190 3200
ALFCKLASLL RSRLTAFGPD VRITVRCLQV LVKGIDAKSL VKNCPEFIRT
3210 3220 3230 3240 3250
SMLTFFNNVA DDLGHTIHYL QDGKYSHLRG THLKTSTSLG YINGVIMPVL
3260 3270 3280 3290 3300
TAMFDHLANC EYGADLLLDE IQVASYKMLG SLFTLGTDST LTHDRKYLKT
3310 3320 3330 3340 3350
EIERHKNALG SCLGAFSSTF PVAFLKPHLN KHNQFSLLNR IADHSLEAQD
3360 3370 3380 3390 3400
VMARMEQSMP TLETILGLVE QFVDSDKTYS DSPHVIDVVL PLLCSYLPFW
3410 3420 3430 3440 3450
WAQGPDNVTP SGGNHVTMVT ADHMNQLLKN VLKLIKKNIG NENAPWMTRI
3460 3470 3480 3490 3500
ATYAQQIIIN SSEELLRESF LPLAERVRKR TDNMFHKEES LRGFIKSSTD
3510 3520 3530 3540 3550
DTSQVESQIQ EDWQLLVRDI YSFYPLLIKY VDLQRNHWLR NNVNEAEELY
3560 3570 3580 3590 3600
NHVAEIFNIW SKSQYFFKEE QNFISANEID NMVLIMPTAT RRVTTVVDGA
3610 3620 3630 3640 3650
PQGGGKVKKK KKHRDKKRDK DKEVQASLMV ACLKRLLPVG LNLFAGREQE
3660 3670 3680 3690 3700
LVQHCKDRFL KKMTEQDVAE FAKTQLTLPD KIDPADEMSW QHYLYSKLGS
3710 3720 3730 3740 3750
KSKTTTAMET AAENKAKIID DTVERIVAMS KVLFGLHMID HPQQMSKNVY
3760 3770 3780 3790 3800
RSVVSIQRKR AVIACFRHLP LHQLPRHRAC NIFSRTYYEL WLEEENIGQE
3810 3820 3830 3840 3850
VMIEDLTQSF EDAELKKSDV EAEGEGKPDP LTQLVTTFCR GAMTERSGAL
3860 3870 3880 3890 3900
QEDPLCMSYA HIIAKSCGEE EEEGGEEEEE GAGEAEGEEE GGASIHEQEM
3910 3920 3930 3940 3950
EKQKLLFHQA RLADRGVAEM VLLHISASKG VPSDMVMKTL QLGISILRGG
3960 3970 3980 3990 4000
NIDIQMGMLN HLKDKKDVGF FTSIAGLMNS CSVLDLDAFE RNTKAEGLGV
4010 4020 4030 4040 4050
GLEGAAGEKN MHDAEFTCAL FRFIQLTCEG HNLEWQNYLR TQAGNTTTVN
4060 4070 4080 4090 4100
VVICTVDYLL RLQESIMDFY WHYSSKELID PAGKANFFKA IGVASQVFNT
4110 4120 4130 4140 4150
LTEVIQGPCT QNQQALAHSR LWDAVGGFLF LFSHMQDKLS KHSSQVDLLK
4160 4170 4180 4190 4200
ELLNLQKDMI TMMLSMLEGN VVNGTIGKQM VDTLVESASN VELILKYFDM
4210 4220 4230 4240 4250
FLKLKDLTTS ASFAEIDANN DGWVLPKDFK EKMEQQKSYT PEEIEFLLAC
4260 4270 4280 4290 4300
CETNHDGKLD YIGFCDRFHE PAKEIGFNLA VLLTNLSEHM PNEPRLARFL
4310 4320 4330 4340 4350
ETAGSVLNYF EPFLGRIEIM GGSKRIERVY FEIKESNIEQ WEKPQIKESK
4360 4370 4380 4390 4400
RAFFYSIVTE GGDKEKLEAF VNFCEDAIFE MTHASGLMAD AEEAGGGPKN
4410 4420 4430 4440 4450
REAAYMYMGD DDDDSRGKDP FRRGLQSVKD GIATAFSSLS PANMKQKIAD
4460 4470 4480 4490 4500
MSQMPPQELA VGFFKMFFYL FYYIGYGALV VVRYIFGVLL GLMRGPQVEE
4510 4520 4530 4540 4550
PPPEPTEEEK IGPSRHLPAL SATDDQGQMA VSAFGLDITK EDNGQVQIKP
4560 4570 4580 4590 4600
HESPGTSSPS SGEEAETAED GEHSGDEPQP PSLIDLLGGE QAKKQAQERI
4610 4620 4630 4640 4650
EAQAAQQAAM SAIEAESKKA VQAPAPSALS QVDLSQYTRR AVSFLARKFY
4660 4670 4680 4690 4700
TLKYVALVLA FCINFVLLFY KVSTLDAEPG EGSGIGDIIS GSGSGSGSGS
4710 4720 4730 4740 4750
GDGGSGEEDE DPIELVHIDE DYFYMEHVIK IAALLHSIVS LAILIGYYHL
4760 4770 4780 4790 4800
KVPLAIFKRE KEIARKLEFD GLYIAEQPED DDLKSHWDKL VISAKSFPVN
4810 4820 4830 4840 4850
YWDKFVKKKV RAKYSETYDF DSISNMLGME KTAFATQEDE GRGFFHYILS
4860 4870 4880 4890 4900
IDWRYQVWKA GVTITDNSFL YSLWYFSFSV MGNFNHFFFA AHLLDVAVGF
4910 4920 4930 4940 4950
KTLRTILQSV THNGKQLVLT VMLLTIIVYI YTVIAFNFFR KFYVQEEDDD
4960 4970 4980 4990 5000
INRNCHDMLT CFVFNLYKGV RAGGGIGDEL EPPDGDDSEA WRIVFDITFF
5010 5020 5030 5040 5050
FFIIVILLAI LQGLIIDAFG ELRDQLESVK EDMESNCFIC GINKDYFDKV
5060 5070 5080 5090 5100
PHGFDTHVQR EHNLANYMFF LMHLINKPDT EYTGQETYVW NMYTQRCWDF
5110
FPVGDCFRKQ YEDAMGE
Length:5,117
Mass (Da):578,482
Last modified:January 25, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE8D73EB2A3EC828
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JF926693 mRNA Translation: AER25354.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF926693 mRNA Translation: AER25354.1

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Y9VX-ray2.84A/B1-205[»]
6LT9X-ray1.80B/F643-837[»]
SMRiG8EME3
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

TCDBi1.A.3.1.9, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG8EME3_PLUXY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G8EME3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: June 2, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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