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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Danio nigrofasciatus (dwarf danio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiDanio nigrofasciatus (dwarf danio)Imported
Taxonomic identifieri144739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 25HelicalSequence analysisAdd BLAST19
Transmembranei45 – 71HelicalSequence analysisAdd BLAST27
Transmembranei92 – 116HelicalSequence analysisAdd BLAST25
Transmembranei136 – 159HelicalSequence analysisAdd BLAST24
Transmembranei171 – 198HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 227COX1InterPro annotationAdd BLAST227

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

G8EHW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KDIGTLYLVF GAWAGMVGTA LSLLIRAELS QPGALLGDDQ IYNVIVTAHA
60 70 80 90 100
FVMIFFMVMP ILIGGFGNWL VPLMIGAPDM AFPRMNNMSF WLLPPSFLLL
110 120 130 140 150
LASSGVEAGA GTGWTVYPPL AGNLAHAGAS VDLTIFSLHL AGVSSILGAI
160 170 180 190 200
NFITTTINMK PPTISQYQTP LFVWAVLVTA VLLLLSLPVL AAGITMLLTD
210 220
RNLNTTFFDP AGGGDPILYQ HLFWFFG
Length:227
Mass (Da):24,275
Last modified:January 25, 2012 - v1
Checksum:iB689F365C3E0C9C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei227Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF915576 Genomic DNA Translation: AEQ64741.1

Similar proteinsi

Entry informationi

Entry nameiG8EHW5_9TELE
AccessioniPrimary (citable) accession number: G8EHW5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: May 23, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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