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Entry version 25 (12 Aug 2020)
Sequence version 1 (25 Jan 2012)
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Protein
Submitted name:

Calcium-release channel VI-2b

Gene

crc-VI-2b

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.Imported

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.2.13, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium-release channel VI-2bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:crc-VI-2bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParamecium tetraureliaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5888 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2399 – 2420HelicalSequence analysisAdd BLAST22
Transmembranei2502 – 2531HelicalSequence analysisAdd BLAST30
Transmembranei2543 – 2564HelicalSequence analysisAdd BLAST22
Transmembranei2626 – 2645HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1871 – 1970RIH_assocInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1411 – 1431DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1051 – 1071Sequence analysisAdd BLAST21
Coiled coili2123 – 2150Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013662, RIH_assoc-dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08454, RIH_assoc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G7ZUA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQNIQLIQV CSNDEILIQC SDLFLSSDGF YPPFIKMKSQ LQIENMIFHI
60 70 80 90 100
FPVQFDNDDI QKLNQQEYIQ YSQDIVIQLA KSNKFICVIV HNDKYILSLT
110 120 130 140 150
NNIDRTTLFR IQPCYKSQIQ NSNKVSFDDD IFLMYSPENI TLQTLEQQSD
160 170 180 190 200
LFVNVNENVK QTSDFIISTT KQTTFQLKKH LKDNQSTSFC YGSLIKIKQI
210 220 230 240 250
ERDSYLELTT NENIQQNPQN NNLHMTDVQT QYQRIYSKNK TIFWRSGERN
260 270 280 290 300
QQNIDLLIYD IWRLYHPQKI NQQIKQGDQF YLQNLSGNFY LNGDQICQNY
310 320 330 340 350
QEASLFSLIE EESINNKLFY ILWNNQYLSY KIINENNFNQ IQDKQLVEYK
360 370 380 390 400
SKKSKLDLLQ FDLISNVDFV HQNWLDNIVH LIYQINLKYQ LHYDDINSFI
410 420 430 440 450
KNQSINDGKF DELFFELQQL EIVLNDLTIF CVADEEKPKI IDKNAIYYLK
460 470 480 490 500
MNQYNQDLLR KKVIVQSLIE FIEIVKWSYD YTQIIEQNKI ESNNDIPIQE
510 520 530 540 550
HNIQFLFQLN TILNQTFLFF EAFSSNNDYN SQIIFLAYFK LKQYLGYNVG
560 570 580 590 600
AFYCLIRLFE NNSNLIPVAG IMPFIGESEK EFDLSLIKRS TRINTILTKQ
610 620 630 640 650
QNQTKSQTLI DEIFERANYC LQILNKRFWG NIMKILSVLC LQNDKACFNN
660 670 680 690 700
QINIGKHIIK GPKILLQIFI KEDNLIYVQI DDKLYELNEI YVQNSKANKD
710 720 730 740 750
FMKDIIECKN FLDSQLNLIG LLCQERNYEN IQFYRTKLPQ KTLINYISYS
760 770 780 790 800
GNAESLRCRL IIILMNLYVD CYPYQPKQIP KLIFNLNKLY GSVQQSNGFN
810 820 830 840 850
AEASSLELQE FQKQSFHKQL TRQFTINDTK AIEKLLTITQ ELVKLNLIQQ
860 870 880 890 900
NQINLSLSVC KILQMFYKLY TFNLPQNKEF HEKYFDVNLL IQAYTLLPQS
910 920 930 940 950
LEQNQPLQEQ VQQFQQFQEQ KEIFNQMSII LIDFLQLYFK QKETKILTSI
960 970 980 990 1000
IKTSQQFDYL DFSQQYNYSR YEKIKENTFL LLKHKQSQTE TQLKAFNLTE
1010 1020 1030 1040 1050
SLYQPKRNII KRLQKCLFLE NQEEVLKYQF IKSMILQLKE LESADEKQQL
1060 1070 1080 1090 1100
YQNCINSLIN LNQLLKKAEN LLLLQKILRI LNVDFILLDF LESYQQICQV
1110 1120 1130 1140 1150
ITQKFNKSNN DNRYILEINN EEESILQFCT QSFIILKYQC NGNNYNKQRI
1160 1170 1180 1190 1200
LSKFNQFDEF LKCIDLGQYD LLQEIYSESY ENIESASSRI IYLLLDNLNF
1210 1220 1230 1240 1250
GSLKVLESLV IQQNISSSKN LFEIIQQIQN SKKLKQQLGF QDNPLDKILS
1260 1270 1280 1290 1300
QNKFQTFQKQ FLIGNMPYTF QIQGIQFVLY LLKYSNPQGC KVLADSFPLQ
1310 1320 1330 1340 1350
QVIKYCTQLK DIFKPKFEDL NLAILNTILK TQLIKLFNVL LNYKEIIKYD
1360 1370 1380 1390 1400
DEIQQTIVLF IDKETKVFES KVVVLDPKMK STNEAQKIYD YIDSNFKFKI
1410 1420 1430 1440 1450
QKQQKENQQL FQQIQSGSEN DSDDSDSKED EQLSECQKQM ACFSLQHNFN
1460 1470 1480 1490 1500
CLYFNDYAML LLNVFLNLAQ LIQEQIENFE ESKSKPGSRA SSTLARQMSL
1510 1520 1530 1540 1550
SQAFAESIAN DMNQSVKLKP FHNLKVKIDL FLKQIEEYLK ANLTKWEIIE
1560 1570 1580 1590 1600
NGHFLIEKSQ QLKILFLRKL EFQNCNLDQI EQQKKDQVVD PYCSPIYCND
1610 1620 1630 1640 1650
NRIHELNLLK NKSENKFIDK QINSFFINEQ ILAIENFDMY FQIYKQQLFM
1660 1670 1680 1690 1700
NEDFEIISEN FSKPIVPLIN CFSSSMNNLN KNFKSAKKIL KFLWHMLDIH
1710 1720 1730 1740 1750
TYIRDDYIQT VKVYELNKKG KYHSKSEQIL QIKAIKAFQN LLVNQGFFEI
1760 1770 1780 1790 1800
FLQFCNSYDK IKIVQQSELF LLNKKKKEKL LYQFLLTSIR LVRGIESANQ
1810 1820 1830 1840 1850
FAQQKLMQEI LKTKSNYMLK IFTSIFERYQ QQDETLKLRS LIQHDINRVY
1860 1870 1880 1890 1900
LAYEFNENHR LEQKKNAMKL GILQVQMKLI QLLAEDHYRP FQDFFREQIG
1910 1920 1930 1940 1950
FAQNYDIIQH LMNILLNFFN QESFYALSQD DYILILNCFD CLKENIQGPC
1960 1970 1980 1990 2000
PQNQEKLCQP QFLRLCGKLL GFDDSQIKFL NLYQRFSKID QALLNQDKER
2010 2020 2030 2040 2050
SRLQTQEQVR KINNLQDKTI IQQQIIQYYI QCPIYCKQLV TSFRKSNSLN
2060 2070 2080 2090 2100
YKLFMLSEIK YRCATTLESL TDNEQNESDI LKRISMIINE KILIRNITIQ
2110 2120 2130 2140 2150
YEKYKILHGS GKNYTNLVFS HLLGEDAKNI EQEKERKKNI QRRKVQIKDS
2160 2170 2180 2190 2200
NTYWYQVEQE VTVESAVKDF WDSFIIETGF SLFNLLAQVY QMKDQDVLER
2210 2220 2230 2240 2250
IYEQIDNTKT QKKKYKSIVF YNLYKAIFQA SQLTKNIRQL QQSAQLSDKI
2260 2270 2280 2290 2300
FNPYKLKKAS GEQEAQQKKL GYRALRFFAT RTGSIEILLP SKQLKKVMFP
2310 2320 2330 2340 2350
LVPHCFALNN VIKEKFASDI DRLSQQRKVE SVLSNSSHII QKLKTEYKFQ
2360 2370 2380 2390 2400
ALYKKNFVIN LLASNQKLWK QIIFLVIVLE NLMILFSSDS NLEKIFGDIL
2410 2420 2430 2440 2450
FGLTITQIIL QFLCFFIFIV KKLPYLRIKS QEIVFEKQIN RIRMREIKYK
2460 2470 2480 2490 2500
YLDNSQSIVL QEDFVLEKTD SFLLEQNKWR RLYFNITDYL TLYKCILLDY
2510 2520 2530 2540 2550
EMIYFLIFTT LAFIGLYVNI VLALLLLDVF WRFPTLTSIV NAIWRPSGSI
2560 2570 2580 2590 2600
LLVLSLYIIM QYYYSLIVYH YYADQYTPYC ENLLQCFSFI LDVTFKTDGG
2610 2620 2630 2640 2650
SVGFVSSSDV YADENYRYSI LNFWEFVYVF VVISLLYSII TGIIIDSFGV
2660 2670 2680 2690 2700
LRDEAEELDN DIKGFCLICG IDRGTLEKKA KHKKGFRFHV KYEHCVWNYI
2710 2720 2730 2740 2750
FYISYLEDKK KSDYNGIESY VDSDLKRESI NWFPINKSLS IPDEEEEQEE
2760 2770
LSNFKQTIDD RLIEIYNKID QLKG
Length:2,774
Mass (Da):329,677
Last modified:January 25, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE67B85CA3655A9A5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR877776 Genomic DNA Translation: CCC21103.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR877776 Genomic DNA Translation: CCC21103.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.3.2.13, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Family and domain databases

InterProiView protein in InterPro
IPR013662, RIH_assoc-dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08454, RIH_assoc, 1 hit
SUPFAMiSSF100909, SSF100909, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG7ZUA5_PARTE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G7ZUA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: August 12, 2020
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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