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Entry version 31 (02 Jun 2021)
Sequence version 1 (25 Jan 2012)
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Protein
Submitted name:

Calcium-release channel I-1a

Gene

crc-I-1a

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channelARBA annotation
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.2.9, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium-release channel I-1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:crc-I-1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParamecium tetraureliaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5888 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2561 – 2578HelicalSequence analysisAdd BLAST18
Transmembranei2605 – 2626HelicalSequence analysisAdd BLAST22
Transmembranei2647 – 2669HelicalSequence analysisAdd BLAST23
Transmembranei2675 – 2704HelicalSequence analysisAdd BLAST30
Transmembranei2725 – 2745HelicalSequence analysisAdd BLAST21
Transmembranei2803 – 2824HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 197MIRInterPro annotationAdd BLAST54
Domaini290 – 367MIRInterPro annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2088 – 2109DisorderedSequence analysisAdd BLAST22
Regioni2436 – 2458DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1155 – 1175Sequence analysisAdd BLAST21
Coiled coili2914 – 2937Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919, MIR, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G7ZU97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQEDLNYLT YGSVISISHV QDDHSFITAD GFVKRAVCLQ NFHHIDVVDV
60 70 80 90 100
KQLGKMKSRP YYHTLFQIFP KFTNTTKQEI LKELIGEEQE EEVQPAVQNI
110 120 130 140 150
LESISKHQKV DEKTILSKEQ VQMFSQKLLQ EFKYNLDTFE KSKAHKVSYK
160 170 180 190 200
SHIQLLHLAS SKFLACHQKE ARVESSNYKI TLDELPSDSS LFKILPAYKY
210 220 230 240 250
QKEGEQVIYA SDIVYIVRAT SFMNKLTFLH ASQEMGNYGK SRKQKKSDED
260 270 280 290 300
LLQYKMEKDI IKREVNAALD EENQTQWRIS VYSDYVPETS GYLKCGDVIW
310 320 330 340 350
LHHSETNTTI AATRKGKPVD QKNFQSFNLV DWLKVENVEL NVLSGSTKES
360 370 380 390 400
YDEYTGDTHS MWIIESEIYK EGGIVVFDKK YRFKHFTSGL YLSGIQDKFT
410 420 430 440 450
LDKQRVPTTL FYFSQLKNSQ VREKSVMRGS YVYICHDKPI PSGTINNQND
460 470 480 490 500
ENSFWVDIQY GKYQRYIPIL HQEQHKTDQS VFKLYASSSN DVWEISFVLS
510 520 530 540 550
CAKTLTNYLD DLQKLKWEND AQDKEVLKDH LLKIQTTKQC IEDINDFCNN
560 570 580 590 600
RLYNSTPEQK YGTINPFRQK LLKEQYYIDL LVKILVQQLK PEDLVIWSRR
610 620 630 640 650
FMIIQMQDIQ QQQEKMSNTE QTNKKQGLKD HEILAYIAFK ITLNQTIYTL
660 670 680 690 700
LTSICKQNPE NELYTFDLIG HFLEHCRYIP EAIKCMISII GNNPELLQQL
710 720 730 740 750
SLNMKLDYIP KEQDFFEPEE EKMQLHHNKI QNNFLIFFLN LLETDEQAHK
760 770 780 790 800
ADFLTFLREM CIYNSQGINS NQEAIYKLLK KHNHKKIQLI KDREDPDKIS
810 820 830 840 850
LKDGKLVIPF KLQNDPKEMY FINEQLQFYA DVSYGRNYLW KQELEQYFSK
860 870 880 890 900
DFLFQNIWQE DGNRTYAVLQ AALCKIAMSL YIDHDPLNKV QLPKYCNLFK
910 920 930 940 950
SIDKANEAQH MGLYTSLIED LFKYLQDNKQ QIVLALDTKD SGDNNKDYDM
960 970 980 990 1000
LEANDEKSLL INELLYNSCQ MMLLVLELDV FLLLDKEPNQ YYKQIIDIVI
1010 1020 1030 1040 1050
HYFFYDFTQL PLMKSVYKVQ KSEITQRKER KEVNPLGIGL NLGANLISMA
1060 1070 1080 1090 1100
NPMNIGLNLN LFGSDEEQKS ESDDDEQIDE GIVDDVQMYT NPLMRGFIKL
1110 1120 1130 1140 1150
ENELQSTLLT REETGSSQLE IKIKLTLCDV MDRFLDMRQN YLMLNCLSFF
1160 1170 1180 1190 1200
KKQIIEKMQE GIQQLKFSKD DASQEQEETK ILIFVQRKTE SNLLGLMPNI
1210 1220 1230 1240 1250
AKTGLKEVDE KEEKQDAFGI GALNFLNKLA ETKPESEEFK VFTQNEMLIY
1260 1270 1280 1290 1300
DLDQYFSLNL PQEDISKINN PIGVVLPYLF TNFSQIHEEE LEKRCLAIIM
1310 1320 1330 1340 1350
RLFNQREELC NNLLKLQLVS DPIKSRLYEF LSENLQRLNQ LVDRSEVWLA
1360 1370 1380 1390 1400
EYIKSQKQDD LEETLEIIDN FRQGFFKDTQ ISSKIISGTQ EIDAEKQNLM
1410 1420 1430 1440 1450
NALKIHLPIL NLIRDQMSAL DFHLENIKNI QRKQRLAQLF IYAFQFLTYF
1460 1470 1480 1490 1500
CRNNHENQIV LSQYISYFEN MHLEVGQIPL ICEIYKDNQK LLTSINRNDR
1510 1520 1530 1540 1550
VFHKFVELIY QSGRKAQFLD FFLTIIKQGN KYIFDNQLLV LNTFLEKEEL
1560 1570 1580 1590 1600
LFTEKNEFVF EGDIQLHQSD FLTDLASNPP MNQPFLYHAK LLDLLLQCTQ
1610 1620 1630 1640 1650
IQVLEGDQKD NFTINVAKLK KKFSAQYMIQ LLCKPDSLCS RNPSLQEQGF
1660 1670 1680 1690 1700
GLIKKQLWIF FMNVHITSEK SQNFLKEIKN DLLNMIDFEI KRLEHIQFDH
1710 1720 1730 1740 1750
QQLRYFDFLI EAVIPLFTTY LIRKNISVHQ DEDEDGHDQE QKDIAAFQAF
1760 1770 1780 1790 1800
AKTLSSKILH LGKYVNRKKH VSVLIAFYSY FPLTIMGKVC QSVSGQSKLM
1810 1820 1830 1840 1850
EDLGEFNGFR DVLSNIQAGA NDNYQSDLNE QVIHLQSGIQ QSHGDHHTPK
1860 1870 1880 1890 1900
TIFQSNNVKS KIGIMSALSS NKKQKEEPLI EFESAEIEKI SGSWEEFVNQ
1910 1920 1930 1940 1950
LCLSDKSKNY VQDELQKLSE AIVKFEQYFG NPSDKNDKNE KILKVEYVIL
1960 1970 1980 1990 2000
LKKFINFLSY AINSSQNNKT IITLLGVLRK VIEGKPKEEQ KEKVEVEGEN
2010 2020 2030 2040 2050
NEMEDVQNLF NKLGATRMVL TVLSESIILD GEMLRNFLLF INTLLSGGNN
2060 2070 2080 2090 2100
KVQKTIFEFM KTYPKSEVIF SRLNNVIQAQ IKQITNKEKD KKTEEQQLGN
2110 2120 2130 2140 2150
LPSQQQEDNV QELKQQQDLE LLLTQVLKFL QNCCEGHYLD LQNYIRQQTN
2160 2170 2180 2190 2200
SRNSFNMINQ VAELLLTYYY KDRAQYENMV LCLDTLNELV QGPCPENQIA
2210 2220 2230 2240 2250
VADSKFFEIA SDLFGQKKEK DSTGKTQIMI SNIKTSKTQN NKMMTSKTGR
2260 2270 2280 2290 2300
YQKQQKGSDL KIWQIERMQT KCLILILSLI EMREISDSNP IIKRIMRHLT
2310 2320 2330 2340 2350
PPLLEKHMVS CFHKYEKQCK EGYQIEVLDR IKEDPESAKQ EDKVKEEQYY
2360 2370 2380 2390 2400
ELILQKGFYI YFLMSYYMES EKNVENSFVQ MYRANTRKKL KQDKGTLEDL
2410 2420 2430 2440 2450
LFGDNIIGQL VSFVMSFANS WIDLMNQIKK EAQKQMATQA QTSEQQEKQD
2460 2470 2480 2490 2500
RERRAEKEKM KRRAFDFFYK NSASIEVVRN NEIEIVYFLL LPYTHNLPKE
2510 2520 2530 2540 2550
QKVEFHENVD RSSTKSKVQF LVQESERLTE ICEHEEQLRR IFQRQKFLAL
2560 2570 2580 2590 2600
FANYVKLWKD LAFLFTLLLN LFIIGSFAQN ESGNRITDFR LFRDEQYSPQ
2610 2620 2630 2640 2650
QTRNIFLICG TIMACCSIFV VSFFLFKNAP LIIKKAWKTK LPFEDKFTYW
2660 2670 2680 2690 2700
PIQLIYKIFK LLAVLFYILK EIEVVYYLAY GALAVIGTVL HPFFFSFHLT
2710 2720 2730 2740 2750
EILIRYPTLK NVIRSVWEPK QQLGLTLVLF VILVYVYGLI AYTFFFEDYK
2760 2770 2780 2790 2800
GKCQSTLFCF LFTFDWTFKA NGGVGGYLSD LEDEDVVEKY RVSRFVFDNT
2810 2820 2830 2840 2850
SNIFLVIIMV NIVAGIIIDT FGSLREEESD KVRDIEDKCF ICGNLKTTFD
2860 2870 2880 2890 2900
RLTDTASMGG GFDHHIKVNH YMWNYVFFMA YLKYKDPTDY TGIEQFVWEK
2910 2920 2930 2940 2950
IQKKDLTWFP FNKARELQNI KQDEEEESKK IERISKDIVN IVDTMRQASQ
2960 2970
MLNSIKNRKK LRNAAKQPAD ML
Length:2,972
Mass (Da):348,963
Last modified:January 25, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48451C11AAF35C1B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR877768 Genomic DNA Translation: CCC21095.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR877768 Genomic DNA Translation: CCC21095.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.3.2.9, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 1 hit
PROSITEiView protein in PROSITE
PS50919, MIR, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG7ZU97_PARTE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G7ZU97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: June 2, 2021
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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