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Protein

Claudin

Gene

CLDN9

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN9Imported
ORF Names:EGM_11389Imported
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000009130 Componenti: Chromosome 20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 144HelicalUniRule annotationAdd BLAST26
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118928
KOiK06087

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

G7Q0A9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLL ALLGLLLAIT
110 120 130 140 150
GAQCTTCVED EGAKARIMLT AGVILLLAGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA AALLMLGGGL LCCTCPPPQV ERPRGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,894
Last modified:January 25, 2012 - v1
Checksum:i6AD818A0CA7FA2CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01041726 Genomic DNA No translation available.
CM001295 Genomic DNA Translation: EHH60097.1
RefSeqiXP_005591078.1, XM_005591021.2

Genome annotation databases

EnsembliENSMFAT00000038076; ENSMFAP00000010009; ENSMFAG00000005034
GeneIDi102139977
KEGGimcf:102139977

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01041726 Genomic DNA No translation available.
CM001295 Genomic DNA Translation: EHH60097.1
RefSeqiXP_005591078.1, XM_005591021.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000038076; ENSMFAP00000010009; ENSMFAG00000005034
GeneIDi102139977
KEGGimcf:102139977

Organism-specific databases

CTDi9080

Phylogenomic databases

GeneTreeiENSGT00760000118928
KOiK06087

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG7Q0A9_MACFA
AccessioniPrimary (citable) accession number: G7Q0A9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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