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Protein

Eukaryotic translation initiation factor 3 subunit H

Gene

EIF3H

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotation
Biological processProtein biosynthesis

Protein family/group databases

MEROPSiM67.971

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit HUniRule annotation
Short name:
eIF3hUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 3UniRule annotation
eIF-3 gammaUniRule annotation
eIF3 p40 subunitUniRule annotation
Gene namesi
Name:EIF3HUniRule annotationImported
Synonyms:EIF3S3UniRule annotation
ORF Names:EGM_17574Imported
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000009130 Componenti: Chromosome 8

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphoserineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 187MPNInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the eIF-3 subunit H family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000111042
KOiK03247

Family and domain databases

CDDicd08065 MPN_eIF3h, 1 hit
HAMAPiMF_03007 eIF3h, 1 hit
InterProiView protein in InterPro
IPR027524 eIF3h
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
PANTHERiPTHR10410:SF3 PTHR10410:SF3, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

G7PCJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSRHAQRIT PGNKMASRKE GTGSTATSSS STTGGAGKGK GKGGSGDSAV
60 70 80 90 100
KQVQIDGLVV LKIIKHYQEE GQGTEVVQGV LLGLVVEDRL EITNCFPFPQ
110 120 130 140 150
HTEDDADFDE VQYQMEMMRS LRHVNIDHLH VGWYQSTYYG SFVTRALLDS
160 170 180 190 200
QFSYQHAIEE SVVLIYDPIK TAQGSLSLKA YRLTPKLMEV CKEKDFSPEA
210 220 230 240 250
LKKANITFEY MFEEVPIVIK NSHLINVLMW ELEKKSAVAD KHELLSLASS
260 270 280 290 300
NHLGKNLQLL MDRVDEMSQD IVKYNTYMRN TSKQQQQKHQ YQQRRQQENM
310 320 330 340 350
QRQSRGEPPL PEEDLSKLFK PPQPPARMDS LLIAGQINTY CQNIKEFTAQ
360
NLGKLFMAQA LQEYNN
Length:366
Mass (Da):41,587
Last modified:January 25, 2012 - v1
Checksum:i82F60CAF6186F15B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01069030 Genomic DNA No translation available.
AQIA01069031 Genomic DNA No translation available.
AQIA01069032 Genomic DNA No translation available.
CM001283 Genomic DNA Translation: EHH64381.1
RefSeqiXP_005564017.1, XM_005563960.2
UniGeneiMfa.4806

Genome annotation databases

EnsembliENSMFAT00000037903; ENSMFAP00000009982; ENSMFAG00000004699
GeneIDi101926641
KEGGimcf:101926641

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01069030 Genomic DNA No translation available.
AQIA01069031 Genomic DNA No translation available.
AQIA01069032 Genomic DNA No translation available.
CM001283 Genomic DNA Translation: EHH64381.1
RefSeqiXP_005564017.1, XM_005563960.2
UniGeneiMfa.4806

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM67.971

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000037903; ENSMFAP00000009982; ENSMFAG00000004699
GeneIDi101926641
KEGGimcf:101926641

Organism-specific databases

CTDi8667

Phylogenomic databases

GeneTreeiENSGT00730000111042
KOiK03247

Family and domain databases

CDDicd08065 MPN_eIF3h, 1 hit
HAMAPiMF_03007 eIF3h, 1 hit
InterProiView protein in InterPro
IPR027524 eIF3h
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
PANTHERiPTHR10410:SF3 PTHR10410:SF3, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG7PCJ5_MACFA
AccessioniPrimary (citable) accession number: G7PCJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: October 10, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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