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UniProtKB - G7P5V1 (G7P5V1_MACFA)

Entry version 18 (07 Apr 2021)
Sequence version 1 (25 Jan 2012)
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Protein

AF-4_C domain-containing protein

Gene

EGM_14523

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF-4_C domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EGM_14523Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9541 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009130 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9541.XP_005555415.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini959 – 1219AF-4_CInterPro annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 322DisorderedSequence analysisAdd BLAST243
Regioni374 – 967DisorderedSequence analysisAdd BLAST594
Regioni1102 – 1130DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili974 – 994Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 142PolarSequence analysisAdd BLAST37
Compositional biasi175 – 198PolyampholyteSequence analysisAdd BLAST24
Compositional biasi221 – 249PolarSequence analysisAdd BLAST29
Compositional biasi271 – 285Pro-richSequence analysisAdd BLAST15
Compositional biasi379 – 434PolarSequence analysisAdd BLAST56
Compositional biasi467 – 494PolarSequence analysisAdd BLAST28
Compositional biasi593 – 613PolarSequence analysisAdd BLAST21
Compositional biasi716 – 730PolarSequence analysisAdd BLAST15
Compositional biasi789 – 841PolyampholyteSequence analysisAdd BLAST53
Compositional biasi842 – 856PolarSequence analysisAdd BLAST15
Compositional biasi918 – 938PolyampholyteSequence analysisAdd BLAST21
Compositional biasi939 – 954PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVDA, Eukaryota

Identification of Orthologs from Complete Genome Data

More...OMAi		YMAMFRY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...PANTHERi		PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G7P5V1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTERVNSS GNSLYNDDRN LLRIREKERR NQEAHQEKEA FPEKIPLFGE 
        60         70         80         90        100
PYKTAKGDEL SSRIQNMLGN YEEVKEFLST KSHTHRLDAS ENRLGKPKYP 
       110        120        130        140        150
LIPDKGSSIP SSSFHTSVHH QSIHTPASGP LSVGNISHNP KMAQPRTEPM 
       160        170        180        190        200
PSLHAKSYGP PDSQHLTQDR LGQEGYGSSH HKKGDRRADG DHCASVTDSA 
       210        220        230        240        250
PERELSPLIS SLPSPVPPLS PIHSNQQTLP RTQGSSKVHG SNNNSKGCCP 
       260        270        280        290        300
AKSPKDLAVK VHDKETPQDS LVAPPQPPSQ TFPPPSLPSK SVAMQQKPTA 
       310        320        330        340        350
YVRPMDGQDQ APSESPELKP LPEDYRQQTF EKTDLKVPAK AKLTKLKMPS 
       360        370        380        390        400
QSVEQTYSNE VHCVEEILKE MTHSWPPPLT AIHTPSTAEP SKFPFPTKDS 
       410        420        430        440        450
QHISSVTQNQ KQYDTSSKTH PNSQQGTSSM LEDDLQLSDS EDSDGEQTPE 
       460        470        480        490        500
KPPSSSAPPS APQSLPEPVA SAHSSSAESE STSDSDSSSD SESESSSSDS 
       510        520        530        540        550
EENEPLETPA PEPEPPTTNK WQLDNWLTKV SQPAAPPEGP GSTEPPPRRP 
       560        570        580        590        600
ESKGSSDGAT SQERSESKDP PPKSSSKAPR APPEAPHPGK RSCQKSPAQQ 
       610        620        630        640        650
EPPQRQTVGT KQPKKPVKAS ARADSRASLQ VEREAGLLPY GSRDQTSKDK 
       660        670        680        690        700
PKVKTKGRPR TAASKEPKPA VPPSSEKKKH KSSLPAPSKA PSGPEPTKDN 
       710        720        730        740        750
VGDRSPEHFA LVPLTQSQGP LHSGGGSRTS GCRQAVVVRE ASRKDRLPLP 
       760        770        780        790        800
LRDTKLLSPL RDTPPPQSLM VKITLDLLSR IPQPPGKGSR QRKAEDKQPP 
       810        820        830        840        850
AGKKHSSEKR SSDSSSKLAK KRKGEAERDC DNKKIRLEKE IKSQSSSSSS 
       860        870        880        890        900
SSSHKESSKA KPCRPSSESS KKEMLPPPPV SSSSQKPAKP AHKRSKREAD 
       910        920        930        940        950
TCGQDPPKSA SSTKSNHKDS STPKHRRVEG KGSRSSSEHK GSSGDTANPF 
       960        970        980        990       1000
PVPSLPNGNS KPGKPQVKFD KQQADLHMRE AKKLKQKAEL MTDKVGKAFK 
      1010       1020       1030       1040       1050
YLEAVLSLIE CGIATESESP ASKSAYSVYS ETVDLIKFIM SLKSFSDATA 
      1060       1070       1080       1090       1100
PTQEKIFAVL CMRCQSILNM AMFRCKKDIA IKYSRTLNKH FESSSKVAQA 
      1110       1120       1130       1140       1150
PSPCVARSTG TPSPLSPMPS PASSVGSQSS AGSVGSSGVA ATISTPVTIQ 
      1160       1170       1180       1190       1200
NMTSSYVTIT SHVLTAFDLW EQAEALTRKN KEFFARLSTN VCTLALNSSL 
      1210       1220 
VDLVHYTRQG FQQLLELTKT P
Length:1,221
Mass (Da):132,367
Last modified:January 25, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC38FC95B64FA0767
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CM001280 Genomic DNA Translation: EHH53819.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001280 Genomic DNA Translation: EHH53819.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9541.XP_005555415.1

Phylogenomic databases

eggNOGiENOG502QVDA, Eukaryota
OMAiYMAMFRY

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG7P5V1_MACFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G7P5V1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: April 7, 2021
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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