Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 44 (02 Jun 2021)
Sequence version 1 (25 Jan 2012)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Adenomatous polyposis protein

Gene

EGK_16751

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathwayARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Adenomatous polyposis proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EGK_16751Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000013456 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MicrotubuleARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 55APC_N_CCInterPro annotationAdd BLAST52
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati754 – 796ARMPROSITE-ProRule annotationAdd BLAST43
Domaini2319 – 2670APC_basicInterPro annotationAdd BLAST352
Domaini2765 – 2937EB1_bindingInterPro annotationAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni315 – 380DisorderedSequence analysisAdd BLAST66
Regioni869 – 888DisorderedSequence analysisAdd BLAST20
Regioni924 – 972DisorderedSequence analysisAdd BLAST49
Regioni1017 – 1038DisorderedSequence analysisAdd BLAST22
Regioni1052 – 1081DisorderedSequence analysisAdd BLAST30
Regioni1152 – 1178DisorderedSequence analysisAdd BLAST27
Regioni1193 – 1262DisorderedSequence analysisAdd BLAST70
Regioni1286 – 1338DisorderedSequence analysisAdd BLAST53
Regioni1404 – 1470DisorderedSequence analysisAdd BLAST67
Regioni1497 – 1571DisorderedSequence analysisAdd BLAST75
Regioni1620 – 1663DisorderedSequence analysisAdd BLAST44
Regioni1677 – 1705DisorderedSequence analysisAdd BLAST29
Regioni1759 – 1811DisorderedSequence analysisAdd BLAST53
Regioni1823 – 1933DisorderedSequence analysisAdd BLAST111
Regioni1975 – 2046DisorderedSequence analysisAdd BLAST72
Regioni2059 – 2106DisorderedSequence analysisAdd BLAST48
Regioni2138 – 2166DisorderedSequence analysisAdd BLAST29
Regioni2242 – 2737DisorderedSequence analysisAdd BLAST496
Regioni2760 – 2808DisorderedSequence analysisAdd BLAST49
Regioni2823 – 2937DisorderedSequence analysisAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili6 – 54Sequence analysisAdd BLAST49
Coiled coili134 – 168Sequence analysisAdd BLAST35
Coiled coili624 – 644Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi320 – 338Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi342 – 380Polar residuesSequence analysisAdd BLAST39
Compositional biasi936 – 951Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1020 – 1038Polar residuesSequence analysisAdd BLAST19
Compositional biasi1052 – 1069Polar residuesSequence analysisAdd BLAST18
Compositional biasi1160 – 1174Polar residuesSequence analysisAdd BLAST15
Compositional biasi1195 – 1224Polar residuesSequence analysisAdd BLAST30
Compositional biasi1226 – 1262Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi1414 – 1468Polar residuesSequence analysisAdd BLAST55
Compositional biasi1527 – 1541Pro residuesSequence analysisAdd BLAST15
Compositional biasi1630 – 1656Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1774 – 1788Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1789 – 1806Polar residuesSequence analysisAdd BLAST18
Compositional biasi1843 – 1857Polar residuesSequence analysisAdd BLAST15
Compositional biasi1881 – 1926Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi1975 – 1989Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1990 – 2009Polar residuesSequence analysisAdd BLAST20
Compositional biasi2018 – 2032Polar residuesSequence analysisAdd BLAST15
Compositional biasi2073 – 2090Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi2265 – 2286Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2295 – 2320Polar residuesSequence analysisAdd BLAST26
Compositional biasi2329 – 2344Polar residuesSequence analysisAdd BLAST16
Compositional biasi2353 – 2521Polar residuesSequence analysisAdd BLAST169
Compositional biasi2556 – 2596Polar residuesSequence analysisAdd BLAST41
Compositional biasi2614 – 2628Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2652 – 2675Polar residuesSequence analysisAdd BLAST24
Compositional biasi2676 – 2691Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2712 – 2737Polar residuesSequence analysisAdd BLAST26
Compositional biasi2764 – 2781Polar residuesSequence analysisAdd BLAST18
Compositional biasi2823 – 2907Polar residuesSequence analysisAdd BLAST85
Compositional biasi2917 – 2937Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenomatous polyposis coli (APC) family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
EVPRVYC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026836, APC
IPR009240, APC_15aa_rpt
IPR009234, APC_basic_dom
IPR026831, APC_dom
IPR026818, Apc_fam
IPR032038, APC_N
IPR036149, APC_N_sf
IPR041257, APC_rep
IPR009223, APC_rpt
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR009232, EB1-bd
IPR009224, SAMP

The PANTHER Classification System

More...
PANTHERi
PTHR12607, PTHR12607, 2 hits
PTHR12607:SF11, PTHR12607:SF11, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05972, APC_15aa, 3 hits
PF05956, APC_basic, 1 hit
PF16689, APC_N_CC, 1 hit
PF05923, APC_r, 7 hits
PF18797, APC_rep, 1 hit
PF00514, Arm, 2 hits
PF05937, EB1_binding, 1 hit
PF05924, SAMP, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185, ARM, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF58050, SSF58050, 1 hit
SSF82931, SSF82931, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176, ARM_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G7MVJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ
60 70 80 90 100
LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE
110 120 130 140 150
GSVSSRSGEC SPVPMGSFPR RGFVNGSRES TGYLEELEKE RSLLLADLDK
160 170 180 190 200
EEKEKDWYYA QLQNLTKRID SLPLTENFSL QTDMTRRQLE YEARQIRVAM
210 220 230 240 250
EEQLGTCQDM EKRAQVADKY IPETGQFIKE RGLRDLTVPR GWGILSIMVE
260 270 280 290 300
GKEEQVVSYM DGGRHVSKGW KSAHQFVNRT YYWDVGIGGV KRRIARIQQI
310 320 330 340 350
EKDILRIRQL LQSQATEAER SSQNKHETGS HDAERQNEGQ GVAEINMATS
360 370 380 390 400
GNGQGSTTRM DHETASVLSS SSTHSAPRRL TSHLGTKVEM VYSLLSMLGT
410 420 430 440 450
HDKDDMSRTL LAMSSSQDSC ISMRQSGCLP LLIQLLHGND KDSVLLGNSR
460 470 480 490 500
GSKEARARAS AALHNIIHSQ PDDKRGRREI RVLHLLEQIR AYCETCWEWQ
510 520 530 540 550
EAHEQGMDQD KNPMPAPVEH QICPAVCVLM KLSFDEEHRH AMNELGRKAT
560 570 580 590 600
RGISSQELGQ GLSGGLQAIA ELLQVDCEMY GLTNDHYSIT LRRYAGMALT
610 620 630 640 650
NLTFGDVANK ATLCSMKGCM RALVAQLKSE SEDLQQVIAS VLRNLSWRAD
660 670 680 690 700
VNSKKTLREV GSVKALMECA LEVKKESTLK SVLSALWNLS AHCTENKADI
710 720 730 740 750
CAVDGALAFL VGTLTYRSQT NTLAIIESGG GILRNVSSLI ATNEDHRQIL
760 770 780 790 800
RENNCLQTLL QHLKSHSLTI VSNACGTLWN LSARNPKDQE ALWDMGAVSM
810 820 830 840 850
LKNLIHSKHK MIAMGSAAAL RNLMANRPAK YKDANIMSPG SSLPSLHVRK
860 870 880 890 900
QKALEAELDA QHLSETFDNI DNLSPKASHR SKQRHKQSLY GDYVFDTNRH
910 920 930 940 950
EDNRSDNFNA GNMTVLSPYL NTTVLPSSSS SRGSLDSSRS EKDRSLERER
960 970 980 990 1000
GIGLGNYHPA TENPGTSSKR GLQISTTAAQ IAKVMEEVSA IHTSQEDRSS
1010 1020 1030 1040 1050
GSTTELHCVT DERNALRRSS AAHTHSNTYN FTKSENSNRT CSMPYAKLEY
1060 1070 1080 1090 1100
KRSSNDSLNS VSSSDGYGKR GQMKPSIESY SEDDESKFCS YGQYPADLAH
1110 1120 1130 1140 1150
KIHSANHMDD NDGELDTPIN YSLKYSDEQL NSGRQSPSQN ERWARPKHII
1160 1170 1180 1190 1200
EDEIKQSEQR QSRSQSTTYP VYTESTDDKH LKFQPHFGQQ ECVSPYRSRG
1210 1220 1230 1240 1250
ANGSETNRVG SNHGINQNVS QSLCQEDDYE DDKPTNYSER YSEEEQHEEE
1260 1270 1280 1290 1300
ERPTNYSIKY NEEKHHVDQP IDYSLKYATD IPSSQKQSFS FSKSSSGQST
1310 1320 1330 1340 1350
KTEHISSSSE NTSTPSSNAK RQNQLHPSSA QSRSGQTQKA ATCKVSSINQ
1360 1370 1380 1390 1400
ETIQTYCVED TPICFSRCSS LSSLSSAEDE IGCDQTTQEA DSANTLQIAE
1410 1420 1430 1440 1450
IKDKIGTRST EDPVSEVPAV SQHTRTKSSR LQGSSLSSES TRHKAVEFSS
1460 1470 1480 1490 1500
GAKSPSKSGA QTPKSPPEHY VQETPLMFSR CTSVSSLDSF ESRSIASSVQ
1510 1520 1530 1540 1550
SEPCSGMVSG IISPSDLPDS PGQTMPPSRS KTPPPPPQTA QTKREVPKNK
1560 1570 1580 1590 1600
TPTAEKRESG PKQAAVNAAV QRVQVLPDAD TLLHFATEST PDGFSCSSSL
1610 1620 1630 1640 1650
SALSLDEPFI QKDVELRIMP PVQENDNGNE TESEQPKESN ENQEKEAEKT
1660 1670 1680 1690 1700
IDSEKDLLDD SDDDDIEILE ECIISAMPTK SSRKAKKPAQ TASKLPPPVA
1710 1720 1730 1740 1750
RKPSQLPVYK LLPSQNRLQP QKHVSFTPGD DMPRVYCVEG TPINFSTATS
1760 1770 1780 1790 1800
LSDLTIESPP NELAAGEGVR AGAQSGEFEK RDTIPTEGRS TDEAQGGKTS
1810 1820 1830 1840 1850
SVTIPELDDN KAEEGDILAE CINSAMPKGK SHKPFRVKKI MDQVQQASAS
1860 1870 1880 1890 1900
SSATNKNQLD GKKKKPTSPV KPIPQNTEYR TRIRKNADSK NNLNAERVFS
1910 1920 1930 1940 1950
DNKDSKKQNL KNNSKDFNDK LPNNEDRVRG SFAFDSPHHY TPIEGTPYCF
1960 1970 1980 1990 2000
SRNDSLSSLD FDDDDVDLSR EKAELRKAKE NKESEAKVTS HTELTSNQQS
2010 2020 2030 2040 2050
ASKTQAIAKH PINRGQLKPI LQKQSTFPQS SKDIPDRGAA TDEKLQNFAI
2060 2070 2080 2090 2100
ENTPVCFSHN SSLSSLSDID QENNNNKENE PIKETEPPDS QGEPSKPQAS
2110 2120 2130 2140 2150
GYAPKSFHVE DTPVCFSRNS SLSSLSIDSE DDLLQECISS AMPKKKKPSR
2160 2170 2180 2190 2200
LKGDNEKHSP RNMGGMLAED LTLDLKDIQR PDSEHGLSPD SENFDWKAIQ
2210 2220 2230 2240 2250
EGANSIVSSL HQAAAAACLS RQASSDSDSI LSLKSGISLG SPFHLTPDQE
2260 2270 2280 2290 2300
EKPFTSNKGP RILKPGEKST LETKKIESES KGIKGGKKVY KSLITGKVRS
2310 2320 2330 2340 2350
NSEISGQMKQ PLQANMPSIS RGRTMIHIPG VRNSSSSTSP VSKKGPPLKT
2360 2370 2380 2390 2400
PASKSPSEGQ TATTSPRGAK PSVKSELSPV ARQTSQIGGS SKAPSRSGSR
2410 2420 2430 2440 2450
DSTPSRPAQQ PLSRPIQSPG RNSISPGRNG ISPPNKLSQL PRTSSPSTAS
2460 2470 2480 2490 2500
TKSSGSGKMS YTSPGRQMSQ QNLTKQTGLS KNASSIPRSE SASKGLNQVN
2510 2520 2530 2540 2550
NGNGANKKVE LSRMSSTKSS GSESDRSERP VLVRQSTFIK EAPSPTLRRK
2560 2570 2580 2590 2600
LEESASFESL SPSSRPASPT RSQAQTPVLS PSLPDMSLST HSSVQAGGWR
2610 2620 2630 2640 2650
KLPPNLSPTI EYNDGRPAKR HDIARSHSES PSRLPINRSG TWKREHSKHS
2660 2670 2680 2690 2700
SSLPRVSTWR RTGSSSSILS ASSESSEKAK SEDEKHVNSI SGTKQSKENQ
2710 2720 2730 2740 2750
VSAKGTWRKI KENEISPTNS TSQTVSSGAT NGAESKTLIY QMAPAVSKTE
2760 2770 2780 2790 2800
DVWVRIEDCP INNPRSGRSP TGNTPPVIDS VSEKGNPNKD SKDNQAKQNV
2810 2820 2830 2840 2850
GNGSVPMRTV GLENRLNSFI QVDAPDQKGT ETKPGQNNPV PVSETNESSI
2860 2870 2880 2890 2900
VERTPFSSSS SSKHSSPSGT VAARVTPFNY NPSPRKSSAD STSARPSQIP
2910 2920 2930
TPVNNNTKKR DSKTDSTESS GTQSPKRHSG SYLVTSV
Length:2,937
Mass (Da):322,134
Last modified:January 25, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CE1DBD750F798A9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM001258 Genomic DNA Translation: EHH26703.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001258 Genomic DNA Translation: EHH26703.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

OMAiEVPRVYC

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026836, APC
IPR009240, APC_15aa_rpt
IPR009234, APC_basic_dom
IPR026831, APC_dom
IPR026818, Apc_fam
IPR032038, APC_N
IPR036149, APC_N_sf
IPR041257, APC_rep
IPR009223, APC_rpt
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR009232, EB1-bd
IPR009224, SAMP
PANTHERiPTHR12607, PTHR12607, 2 hits
PTHR12607:SF11, PTHR12607:SF11, 2 hits
PfamiView protein in Pfam
PF05972, APC_15aa, 3 hits
PF05956, APC_basic, 1 hit
PF16689, APC_N_CC, 1 hit
PF05923, APC_r, 7 hits
PF18797, APC_rep, 1 hit
PF00514, Arm, 2 hits
PF05937, EB1_binding, 1 hit
PF05924, SAMP, 3 hits
SMARTiView protein in SMART
SM00185, ARM, 7 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF58050, SSF58050, 1 hit
SSF82931, SSF82931, 1 hit
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG7MVJ3_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G7MVJ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: June 2, 2021
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again