UniProtKB - G7MRI3 (G7MRI3_MACMU)
Protein
C-domain 1
Gene
TNLG1F
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.ARBA annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- transcription regulatory region sequence-specific DNA binding Source: Ensembl
- tumor necrosis factor receptor binding Source: Ensembl
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- activation of MAPK activity Source: Ensembl
- activation of MAPKKK activity Source: Ensembl
- cellular response to amino acid stimulus Source: Ensembl
- cellular response to nicotine Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- chronic inflammatory response to antigenic stimulus Source: Ensembl
- cortical actin cytoskeleton organization Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- embryonic digestive tract development Source: Ensembl
- endothelial cell apoptotic process Source: Ensembl
- epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
- extracellular matrix organization Source: Ensembl
- extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- glucose metabolic process Source: Ensembl
- humoral immune response Source: Ensembl
- intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- JNK cascade Source: Ensembl
- leukocyte tethering or rolling Source: Ensembl
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- microglial cell activation Source: Ensembl
- necroptotic signaling pathway Source: Ensembl
- negative regulation of alkaline phosphatase activity Source: Ensembl
- negative regulation of amyloid-beta clearance Source: Ensembl
- negative regulation of bicellular tight junction assembly Source: Ensembl
- negative regulation of blood vessel endothelial cell migration Source: Ensembl
- negative regulation of branching involved in lung morphogenesis Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of cytokine production involved in immune response Source: Ensembl
- negative regulation of endothelial cell proliferation Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of glucose import Source: Ensembl
- negative regulation of interleukin-6 production Source: Ensembl
- negative regulation of lipid catabolic process Source: Ensembl
- negative regulation of mitotic cell cycle Source: Ensembl
- negative regulation of myoblast differentiation Source: Ensembl
- negative regulation of myosin-light-chain-phosphatase activity Source: Ensembl
- negative regulation of osteoblast differentiation Source: Ensembl
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
- negative regulation of protein-containing complex disassembly Source: Ensembl
- negative regulation of signaling receptor activity Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of vascular wound healing Source: Ensembl
- negative regulation of viral genome replication Source: Ensembl
- osteoclast differentiation Source: Ensembl
- positive regulation of amyloid-beta formation Source: Ensembl
- positive regulation of blood microparticle formation Source: Ensembl
- positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
- positive regulation of calcineurin-NFAT signaling cascade Source: Ensembl
- positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
- positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
- positive regulation of cytokine production involved in inflammatory response Source: Ensembl
- positive regulation of fever generation Source: Ensembl
- positive regulation of glial cell proliferation Source: Ensembl
- positive regulation of hair follicle development Source: Ensembl
- positive regulation of heterotypic cell-cell adhesion Source: Ensembl
- positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of I-kappaB phosphorylation Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of interleukin-33 production Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of interleukin-8 production Source: Ensembl
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of JUN kinase activity Source: Ensembl
- positive regulation of leukocyte adhesion to arterial endothelial cell Source: Ensembl
- positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of osteoclast differentiation Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of phagocytosis Source: Ensembl
- positive regulation of podosome assembly Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
- positive regulation of protein-containing complex disassembly Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- positive regulation of protein localization to cell surface Source: Ensembl
- positive regulation of protein localization to plasma membrane Source: Ensembl
- positive regulation of protein transport Source: Ensembl
- positive regulation of superoxide dismutase activity Source: Ensembl
- positive regulation of synaptic transmission Source: Ensembl
- positive regulation of synoviocyte proliferation Source: Ensembl
- positive regulation of translational initiation by iron Source: Ensembl
- positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- positive regulation of vitamin D biosynthetic process Source: Ensembl
- protein kinase B signaling Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- regulation of branching involved in salivary gland morphogenesis Source: Ensembl
- regulation of endothelial cell apoptotic process Source: Ensembl
- regulation of establishment of endothelial barrier Source: Ensembl
- regulation of immunoglobulin secretion Source: Ensembl
- regulation of insulin secretion Source: Ensembl
- regulation of synapse organization Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to virus Source: Ensembl
- sequestering of triglyceride Source: Ensembl
- tumor necrosis factor-mediated signaling pathway Source: Ensembl
- vascular endothelial growth factor production Source: Ensembl
Keywordsi
Molecular function | CytokineARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: C-domain 1ARBA annotationAlternative name(s): C-domain 2ARBA annotation CachectinARBA annotation Intracellular domain 1ARBA annotation Intracellular domain 2ARBA annotation N-terminal fragmentARBA annotation TNF-alphaARBA annotation Tumor necrosis factorARBA annotation Tumor necrosis factor ligand superfamily member 2ARBA annotation Tumor necrosis factor, membrane formARBA annotation Tumor necrosis factor, soluble formARBA annotation |
Gene namesi | Name:TNLG1FImported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Endosome
- recycling endosome Source: Ensembl
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: Ensembl
- phagocytic cup Source: Ensembl
Other locations
- membrane raft Source: Ensembl
Keywords - Cellular componenti
Cell membraneARBA annotation, Membrane, SecretedARBA annotationPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, Lipoprotein, MyristateARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMMUG00000008845, Expressed in kidney and 12 other tissues |
ExpressionAtlasi | G7MRI3, baseline |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- tumor necrosis factor receptor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 89 – 233 | TNF_2InterPro annotationAdd BLAST | 145 |
Sequence similaritiesi
Belongs to the tumor necrosis factor family.ARBA annotation
Keywords - Domaini
Signal-anchorARBA annotation, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
HOGENOMi | CLU_070352_3_1_1 |
OMAi | GATMLFC |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G7MRI3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTESMIRDV ELAEEALPRK TAGPQGSRRC WFLSLFSFLL VAGATTLFCL
60 70 80 90 100
LHFGVIGPQR EEFPKDPSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
110 120 130 140 150
QLQWLNRRAN ALLANGVELT DNQLVVPSEG LYLIYSQVLF KGQGCPSNHV
160 170 180 190 200
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
210 220 230
QLEKGDRLSA EINLPDYLDF AESGQVYFGI IAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN874362 mRNA Translation: CTQ86127.1 |
RefSeqi | NP_001040614.1, NM_001047149.1 |
Genome annotation databases
GeneIDi | 715467 |
KEGGi | mcc:715467 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN874362 mRNA Translation: CTQ86127.1 |
RefSeqi | NP_001040614.1, NM_001047149.1 |
3D structure databases
SMRi | G7MRI3 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 715467 |
KEGGi | mcc:715467 |
Organism-specific databases
CTDi | 7124 |
Phylogenomic databases
HOGENOMi | CLU_070352_3_1_1 |
OMAi | GATMLFC |
Gene expression databases
Bgeei | ENSMMUG00000008845, Expressed in kidney and 12 other tissues |
ExpressionAtlasi | G7MRI3, baseline |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G7MRI3_MACMU | |
Accessioni | G7MRI3Primary (citable) accession number: G7MRI3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 25, 2012 |
Last sequence update: | January 25, 2012 | |
Last modified: | February 10, 2021 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |