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Entry version 53 (08 May 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Teneurin-1

Gene

ten-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ten-1
ORF Names:R13F6.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
R13F6.4a ; CE46838 ; WBGene00006498 ; ten-1
R13F6.4d ; CE42908 ; WBGene00006498 ; ten-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 216CytoplasmicSequence analysisAdd BLAST216
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 2684ExtracellularSequence analysisAdd BLAST2447

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Shows gonad disorganization, nerve cord defasciculation and defects in distal tip cell migration and axonal pathfinding. Shows local basement membrane deficiency and early gonad disruption.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004210191 – 2684Teneurin-1Add BLAST2684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi467 ↔ 476PROSITE-ProRule annotation
Disulfide bondi472 ↔ 487PROSITE-ProRule annotation
Disulfide bondi489 ↔ 498PROSITE-ProRule annotation
Disulfide bondi505 ↔ 516PROSITE-ProRule annotation
Disulfide bondi510 ↔ 522PROSITE-ProRule annotation
Disulfide bondi524 ↔ 533PROSITE-ProRule annotation
Disulfide bondi654 ↔ 666PROSITE-ProRule annotation
Disulfide bondi659 ↔ 672PROSITE-ProRule annotation
Disulfide bondi674 ↔ 683PROSITE-ProRule annotation
Disulfide bondi720 ↔ 730PROSITE-ProRule annotation
Disulfide bondi724 ↔ 741PROSITE-ProRule annotation
Disulfide bondi743 ↔ 752PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably proteolytically processed to generate a N-terminal intracellular domain.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EGQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EGQ6

PeptideAtlas

More...
PeptideAtlasi
G5EGQ6

PRoteomics IDEntifications database

More...
PRIDEi
G5EGQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is mainly expressed in organs derived from the mesoderm, including the pharynx, vulva muscles, gonad distal tip cells, intestine and several tail neurons. Isoform 2 is mainly expressed in the organs derived from the ectoderm, including hypodermal cells, head ganglion neurons and tail neurons (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is expressed in a cluster of cells in the anterior half at 2.5 hours post fertilization (hpf), in hypodermal cells at 5 hpf, in pharyngeal cells, intestinal and some neurons at 6 hpf. Isoform 1 is expressed in pharyngeal cells at L1 larval stage. Isoform 1 is expressed in somatic gonad precursor cells (SGPs) during the L2 larval stage. Isoform 2 is expressed in anterior neuronal cells and posterior hypodermal cells at 5 hpf, in neurons of the head at 7.6 hpf (at protein level). Expressed in somatic gonad founder cells Z1 and Z4, pharynx and muscles.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006498 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5EGQ6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
41168, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.R13F6.4e

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EGQ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini463 – 499EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini501 – 534EGF-like 2PROSITE-ProRule annotationAdd BLAST34
Domaini650 – 684EGF-like 3PROSITE-ProRule annotationAdd BLAST35
Domaini716 – 753EGF-like 4PROSITE-ProRule annotationAdd BLAST38
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1276 – 1317NHL 1Add BLAST42
Repeati1334 – 1378NHL 2Add BLAST45
Repeati1398 – 1441NHL 3Add BLAST44
Repeati1470 – 1513NHL 4Add BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 202Poly-Lys5
Compositional biasi257 – 261Poly-Ala5
Compositional biasi781 – 789Poly-Ser9
Compositional biasi2351 – 2355Poly-Ser5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225 Eukaryota
KOG4659 Eukaryota
ENOG410XQQD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182725

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EGQ6

Database of Orthologous Groups

More...
OrthoDBi
7516at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EGQ6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013017 NHL_repeat_subgr
IPR028916 Tox-GHH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15636 Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 4 hits
PS51125 NHL, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: G5EGQ6-1) [UniParc]FASTAAdd to basket
Also known as: ten-1a, ten-1L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQHRTTNAQ GPPPNRPMPR PPAGMPMMTS SHEHDYTNDY EDPEEMARSR
60 70 80 90 100
GEGFSNHLLI KTTPPPQPHP NFNSYEMSMS QQRRSQQHQQ PMAPPLSDCW
110 120 130 140 150
GSGVHDSGVL HKNADGAYYI PSGSLRTTSS TLSPASGQRY LDQPHTSGGA
160 170 180 190 200
PNPTYSDAST TLLKYPLAAG TNQNRRRQQV GTMNNGDPVA GGPMALSKKK
210 220 230 240 250
KKFDDDSDTC SRWPSKWNIL LAAALLVALF VICILLFRAP NYVYTQPAPS
260 270 280 290 300
SDATSSAAAA ASRYQDLGLR ALPPAISLGE RVDVEFFPKS MATTELTVTK
310 320 330 340 350
PSRIRFNATV GSGAQLVLLM SAGVHPSLSL HDALFPIRAD RIRDSKSPTH
360 370 380 390 400
IVEEFGSRSR RSLGASSSRH RNIEILSPRS ATFEQFVLEG RHYLTFINER
410 420 430 440 450
SRVEPISFVA EELQRPTTPP KTSSSGTSGA KEHPLASVLV CESNCNQRGE
460 470 480 490 500
CVHGKCHCAP GFTGRTCDEA VCPVVCSGNG VFSGGICVCK SGFKGKECEM
510 520 530 540 550
RHNWCEVADC NGRGRCDTDG RCRCNPGWTG EACELRACPH ASCHDRGVCV
560 570 580 590 600
NGTCYCMDGW RGNDCSVFAD AIVHVPQAQS PPRRGQEPTE SSKTRKAQVK
610 620 630 640 650
PTPTSEKKKE SRELQKPIIA TVQVPTESSH PCSAHGQLID DICQCESGWD
660 670 680 690 700
SVDCSQQACQ CVNGDCLDDG SCQCWKGWRG SNCTDKKCAI GCEDRGKCAS
710 720 730 740 750
DGSCKCSSGW NGENCAIDGC PNQCSGKGEC GMDRRSSEWS CRCQAGSTGV
760 770 780 790 800
DCSVSVEMHC DDGLDNDSDG LIDCDDPECC SSSSCSSESV CSTAASPIEV
810 820 830 840 850
LMRMPPIFNA NFAQRVGFLI MEKSVQSYTD SSQFNENLIS VIRGRVMWGG
860 870 880 890 900
SPTGSDDLST YSNKSTVPLV GVRVSDAAHP LYGFTLTRED GYFDLTVNGA
910 920 930 940 950
RSVTLQFLRT QFQSVKKSVF VSPRQIIHID DIVLYRQSGG SPPAISMAPA
960 970 980 990 1000
RAKCSPTLRR IPDVVLISNW QYTSDGIETD ETSDSSRIVV DSRSIFESLP
1010 1020 1030 1040 1050
IQGTDVRLVY DSARSPAAPS TMLIGLLYDR VDKELRKVHI NIRIAGRRFD
1060 1070 1080 1090 1100
RVLAPRTNLT YVFAWDKMNA YRQSESGLVP VTVRVGYEYQ GCDRTSERVW
1110 1120 1130 1140 1150
QTRRSQMMGA TARKMIGTMW TLDIHHHLDI VNNVVEMGNG GYRLITESEP
1160 1170 1180 1190 1200
RVSTFAGLDG VKRDVECLKC EGKVDSISLF RPTTVVYAQD GSLIIGDHNM
1210 1220 1230 1240 1250
IRRVSQDGQV STILTLGLAD TSHSYYIAVS PVDGTIAISL PLHKQVWRIS
1260 1270 1280 1290 1300
SLEPQDSRNN YDVLAGDGTV CASAVDSCGD GALAQNAQLI FPKGISFDKM
1310 1320 1330 1340 1350
GNLYLADSRR IRVIDTTGHI RSIGETTPDQ HPIRTCAQIT KLVDLQMEWP
1360 1370 1380 1390 1400
TSLTIDPITG SVLVLDTNVV YEIDVVHDVV TIALGSPTTC DLANATSSAS
1410 1420 1430 1440 1450
AKSLDHRRHL IQNARDITVG TDGAIYVVES DGRRLNQVRK LSSDRSTFSI
1460 1470 1480 1490 1500
LTGGKSPCSC DVAACGCDDA VSLRDVAASQ AHLSSPYAVC VSPSGDVIIA
1510 1520 1530 1540 1550
DSGNSKIKKV SARMAKYDGR SRTYEVTDAE RQEKYTFNRH GQHSSTVSLI
1560 1570 1580 1590 1600
TGRTFFNFSY QVDSPISMIS EIRAASGVVL RVLKRNDSLF DLETTLGQRT
1610 1620 1630 1640 1650
TLTMSAYDGT LEQVSKRDSA TSRDATKLFY KKGLLTSRID VATAVGFEYD
1660 1670 1680 1690 1700
EYGRAIGLKR DREYWRLGEE TISMGSVNTE VLLNGQRFQQ VRLGEGNLAV
1710 1720 1730 1740 1750
HSTNGATTRL ISLRNEGYSL ASPLGTSTLY DKSSSIPDSN GEPLISRRRT
1760 1770 1780 1790 1800
KVPAIGNPQR RELTTRWDWR HVARRGDDSD GSLGRRKVAE INGVNMFSME
1810 1820 1830 1840 1850
YDVKSNQDTL RLGSTTDDAQ ALLFIDYTSS GRIRRISAPE DSQMAEMNIT
1860 1870 1880 1890 1900
WDGAGRKSEV TWGSWKIRLT YDNSNRLTEH AIDGARVPIK MSYAGASRRP
1910 1920 1930 1940 1950
NEIQHDGAKW NIQYDNYDRI KEVISKSQEA TSFSSIALGG DEWVLKRRTS
1960 1970 1980 1990 2000
LNSKPSLVRL SREGKVLEST TPDENHYWLE RKDPITGRTT EILNDEETTV
2010 2020 2030 2040 2050
VTCWSPEGAP MCSRSRNLQE NTTMQGHLVA RKSVTIMTPT SSEPSITSSF
2060 2070 2080 2090 2100
TYEYDDMLRV TTIQPVIEQS VLESIQLSYD ERRGHVAAIN GFKWARDAST
2110 2120 2130 2140 2150
SRCQGHGLMY ETSKANDHRQ VVERKLIFGD ARASIKIIRD KAGRASESHL
2160 2170 2180 2190 2200
EISSSGTQRN QKITRTFDAA GRVASVEQND QEPVRIIWNS DARVEKINDR
2210 2220 2230 2240 2250
VVEWNRGGAL KTFQDISYQV DSIGWVVKRD NTTVFGYDGK GRLVSARSSQ
2260 2270 2280 2290 2300
LRINIFYDRE DRVVQIQNSK DFIHFYYGYI DTPKLVSHFS KNGKISTLFY
2310 2320 2330 2340 2350
DDDSVPFAMQ SDDGTRYALL TDETSTIKAI IGDSNVLRII DRSVFGALLP
2360 2370 2380 2390 2400
SSSSSHPFLP IGYLGGIEIS EISVSILNNG RPLDLYSERY MSISPEAVVR
2410 2420 2430 2440 2450
LELNEKFSNS IDLMALEIDR QPFRVENVPE DFETWFSLAG LSPNLLPSAH
2460 2470 2480 2490 2500
LGLPASSAIV HRLLSSFPRK LRPLTHLTTV LPTRLASDIS LTSPTSETSW
2510 2520 2530 2540 2550
SIDDVGFSNL LILNEDATTG EVMVEMLSDL KSEEREVISK LFDGVKSLDF
2560 2570 2580 2590 2600
ATWGLVPTRH LWRAPNSKLE LSSTSFSHFT MAVNKDSVEL RNGKSKIVVH
2610 2620 2630 2640 2650
FSENKAEIVK KIVEELKTRE NIAVWRAERK RAEAGEKTWR QWSDRETREL
2660 2670 2680
TSKGSVSGYD IEMKPAHQSG LLASVHSWKF RKSE
Length:2,684
Mass (Da):296,470
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7FBDFBA51AB2776
GO
Isoform 2 (identifier: G5EGQ6-2) [UniParc]FASTAAdd to basket
Also known as: ten-1b, ten-1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Show »
Length:2,502
Mass (Da):276,402
Checksum:iF3131A6ED7728AA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H1ZUX0H1ZUX0_CAEEL
Teneurin-1
ten-1 CELE_R13F6.4, R13F6.4
2,837Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H1ZUX1H1ZUX1_CAEEL
Teneurin-1
ten-1 CELE_R13F6.4, R13F6.4
2,763Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8I7J1Q8I7J1_CAEEL
Teneurin-1
ten-1 CELE_R13F6.4, R13F6.4
860Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450231 – 182Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB206835 mRNA Translation: BAD91086.1
AB206836 mRNA Translation: BAD91087.1
FO081247 Genomic DNA Translation: CCD70175.2
FO081247, FO081246 Genomic DNA Translation: CCD70183.1

NCBI Reference Sequences

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RefSeqi
NP_001022723.2, NM_001027552.3 [G5EGQ6-1]
NP_741203.2, NM_171175.2 [G5EGQ6-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
R13F6.4a; R13F6.4a; WBGene00006498 [G5EGQ6-2]
R13F6.4d; R13F6.4d; WBGene00006498 [G5EGQ6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
175953

UCSC genome browser

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UCSCi
R13F6.4a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB206835 mRNA Translation: BAD91086.1
AB206836 mRNA Translation: BAD91087.1
FO081247 Genomic DNA Translation: CCD70175.2
FO081247, FO081246 Genomic DNA Translation: CCD70183.1
RefSeqiNP_001022723.2, NM_001027552.3 [G5EGQ6-1]
NP_741203.2, NM_171175.2 [G5EGQ6-2]

3D structure databases

SMRiG5EGQ6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi41168, 1 interactor
STRINGi6239.R13F6.4e

Proteomic databases

EPDiG5EGQ6
PaxDbiG5EGQ6
PeptideAtlasiG5EGQ6
PRIDEiG5EGQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR13F6.4a; R13F6.4a; WBGene00006498 [G5EGQ6-2]
R13F6.4d; R13F6.4d; WBGene00006498 [G5EGQ6-1]
GeneIDi175953
UCSCiR13F6.4a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
175953
WormBaseiR13F6.4a ; CE46838 ; WBGene00006498 ; ten-1
R13F6.4d ; CE42908 ; WBGene00006498 ; ten-1

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG4659 Eukaryota
ENOG410XQQD LUCA
GeneTreeiENSGT00950000182725
InParanoidiG5EGQ6
OrthoDBi7516at2759
PhylomeDBiG5EGQ6

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EGQ6

Gene expression databases

BgeeiWBGene00006498 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiG5EGQ6 baseline and differential

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013017 NHL_repeat_subgr
IPR028916 Tox-GHH_dom
PfamiView protein in Pfam
PF15636 Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 7 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 4 hits
PS51125 NHL, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEN1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EGQ6
Secondary accession number(s): B5BM17, Q5CCJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: December 14, 2011
Last modified: May 8, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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