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Entry version 65 (02 Jun 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Daf-12-interacting protein 1

Gene

din-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Daf-12-interacting protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:din-1Imported
ORF Names:F07A11.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F07A11.6a ; CE37499 ; WBGene00008549 ; din-1
F07A11.6b ; CE32618 ; WBGene00008549 ; din-1
F07A11.6c ; CE32619 ; WBGene00008549 ; din-1
F07A11.6d ; CE03148 ; WBGene00008549 ; din-1
F07A11.6e ; CE37500 ; WBGene00008549 ; din-1
F07A11.6f ; CE45315 ; WBGene00008549 ; din-1
F07A11.6g ; CE45296 ; WBGene00008549 ; din-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout of isoform d results in defective dauer formation. Eighteen percent of temperature sensitive mutants are embryonic lethal. The surviving animals are small (Sma), clear (Clr), uncoordinated, constipated and sterile. They display variable morphological defects in the main body and pharynx.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004339901 – 2407Daf-12-interacting protein 1CuratedAdd BLAST2407

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EGK6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EGK6

PeptideAtlas

More...
PeptideAtlasi
G5EGK6

PRoteomics IDEntifications database

More...
PRIDEi
G5EGK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform d is widely expressed: detected in the hypodermis, seam cells, intestine, somatic gonad, neurons, vulval precursors, body wall muscle and pharynx.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoforms b and d are widely expressed from embryogenesis to adulthood. Isoform d is highly expressed in late L1 and L2 larval stages in XXX neuroendocrine cells. Isoform b is expressed more highly in the embryo and the L1 larval stage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008549, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform d interacts with daf-12.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F07A11.6b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EGK6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini277 – 335RRMPROSITE-ProRule annotationAdd BLAST59
Domaini2213 – 2383SPOCPROSITE-ProRule annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni90 – 152DisorderedSequence analysisAdd BLAST63
Regioni439 – 632DisorderedSequence analysisAdd BLAST194
Regioni737 – 767DisorderedSequence analysisAdd BLAST31
Regioni785 – 849DisorderedSequence analysisAdd BLAST65
Regioni874 – 896DisorderedSequence analysisAdd BLAST23
Regioni921 – 986DisorderedSequence analysisAdd BLAST66
Regioni993 – 1012DisorderedSequence analysisAdd BLAST20
Regioni1025 – 1844DisorderedSequence analysisAdd BLAST820
Regioni1858 – 1918DisorderedSequence analysisAdd BLAST61
Regioni1932 – 1976DisorderedSequence analysisAdd BLAST45
Regioni2077 – 2103DisorderedSequence analysisAdd BLAST27
Regioni2172 – 2200DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2049 – 2110Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi90 – 115Polar residuesSequence analysisAdd BLAST26
Compositional biasi441 – 468Polar residuesSequence analysisAdd BLAST28
Compositional biasi469 – 487Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi488 – 505Polar residuesSequence analysisAdd BLAST18
Compositional biasi506 – 529Acidic residuesSequence analysisAdd BLAST24
Compositional biasi530 – 565Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi587 – 606Polar residuesSequence analysisAdd BLAST20
Compositional biasi614 – 629Polar residuesSequence analysisAdd BLAST16
Compositional biasi786 – 849Polar residuesSequence analysisAdd BLAST64
Compositional biasi924 – 966Polar residuesSequence analysisAdd BLAST43
Compositional biasi1042 – 1071Polar residuesSequence analysisAdd BLAST30
Compositional biasi1072 – 1148Basic and acidic residuesSequence analysisAdd BLAST77
Compositional biasi1175 – 1197Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1207 – 1228Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1235 – 1264Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1281 – 1328Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi1336 – 1398Basic and acidic residuesSequence analysisAdd BLAST63
Compositional biasi1457 – 1503Polar residuesSequence analysisAdd BLAST47
Compositional biasi1515 – 1548Polar residuesSequence analysisAdd BLAST34
Compositional biasi1563 – 1593Polar residuesSequence analysisAdd BLAST31
Compositional biasi1610 – 1653Polar residuesSequence analysisAdd BLAST44
Compositional biasi1676 – 1693Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1701 – 1730Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1748 – 1768Polar residuesSequence analysisAdd BLAST21
Compositional biasi1808 – 1829Polar residuesSequence analysisAdd BLAST22
Compositional biasi1867 – 1892Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1897 – 1918Polar residuesSequence analysisAdd BLAST22
Compositional biasi2077 – 2100Basic and acidic residuesSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0112, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EGK6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRDIPHE

Database of Orthologous Groups

More...
OrthoDBi
367857at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.290.10, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR016194, SPOC-like_C_dom_sf
IPR012921, SPOC_C
IPR010912, SPOC_met

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 1 hit
PF07744, SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939, SSF100939, 1 hit
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit
PS50917, SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform bImported (identifier: G5EGK6-1) [UniParc]FASTAAdd to basket
Also known as: din-1LA1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQVPSTNTV KESRHVAISG LPSTLPDDRL QLHFTKFGEI QRLVRQHGNP
60 70 80 90 100
EIVLVSYMDA RGALRARSTK PQFEDSIEYK ISAYIPEPTQ NSSMASMSST
110 120 130 140 150
PSSGQSSSPR NAELSPQRYG DTRGAEVKSP SFRNQMEARR GGPHLSVQSQ
160 170 180 190 200
QRHSREYWPI PEFPSESTAC VVYEIQSGST PERDLFELVK KHSKRSGVPI
210 220 230 240 250
DIQLESTTEP GWKKARVHYY RLDTDGLKAD KSLILGRPPK FRVYYPTSGE
260 270 280 290 300
QKHPQCHPST SYAIPKLKGD HLLKASCSVH VPHLDRHSPD HYRRRFESYG
310 320 330 340 350
QVIDVDMVKS NDNKAFAVVQ FTNIDDAQKA LQDTNIPKPM SYQSRPSHRI
360 370 380 390 400
IIFYLPIECT NEEIMLIIRS LSDRIVDICV DWWDRSAVIT LDDMEPANLL
410 420 430 440 450
LKRMKLVGRN NFGEHKVAVD FCSDRFNLYF INRKKENIEV AARSSSPTSK
460 470 480 490 500
SENDQGSSSP SSSRDRQNLH DPLQTRSSVE HHTNQEDQEN NASGSDSSSD
510 520 530 540 550
SDSEEGSSSS NEDSDEQNDV DEEDDEDVVS EEKRHEPEEG KSSSPGNGHR
560 570 580 590 600
DESNGDKDHE DSSERFSQPS TSSHHETSHS PEKDSEAYQS RSFSPLNYQS
610 620 630 640 650
QSPGYEFLES KEIKQEFSPT TSSASSSDLE LDMEMPDNPL TRMLERMHWR
660 670 680 690 700
PFIDVSSFVN RIDEIVELNQ KARASYEKFT GRPFPKCNND EVLSIQKIVF
710 720 730 740 750
HEPRDYYYYE NPCSELEVRI RDWRKLSDTA DLDDFRATDS KELGRDQPAG
760 770 780 790 800
GRTSGRPSLD ESRTNRLSFD STHHPAELAQ RSHSLCIGPM TPSTPFPTSQ
810 820 830 840 850
PLLVNTTHLP GTSQPSTSGG ITTPRSSQPP PLMSPVSRHN SMSSTGRPAS
860 870 880 890 900
IQTLRHQSVM FPPDVSIPPP PIPPTHDEMM APRGTPPSRR SSETMVPLRS
910 920 930 940 950
PPFGTPIQNL LTMPIVPPPH LIAATSTGTH SVSSSAHSTP RHSISGTPVH
960 970 980 990 1000
CEPSNSKTSQ PPTPKSRPEK VQIRHDTISK SGPSNAINAL QARSQSMTSG
1010 1020 1030 1040 1050
DPKKSAPSTP VVRDAGSDLV AQIMSNQPNL GLRKLPRIEK KSSALQNIQN
1060 1070 1080 1090 1100
HQPPHSNANS TPSTPSTSTH QAMFKDKEKE RKKKEKEKEE REREARREMK
1110 1120 1130 1140 1150
RKETKEERNK RKEMERAKRL EDERQERKRE KKKERDERKK EKEKVRKKAE
1160 1170 1180 1190 1200
KEKLKKKKHR KGDSSDESDS DSNDELDLDV RKSTKEMTQE EKDHQLALLL
1210 1220 1230 1240 1250
SKGGIIENLK SRRRSDKRAH DSFEKMQQKS QQRRVLIESS DDEGGKDGDK
1260 1270 1280 1290 1300
GNSSNGEESD SEKADLPPPP APPSLSESAD QRLKVLKERE KGELTTSSDD
1310 1320 1330 1340 1350
EDHNDAGEIH QQRLTEDREN RKRQKSLTAY SSDEQGERKN VPKRMRRDDS
1360 1370 1380 1390 1400
EDAAAKHPGW SAKDDQKQRK RKLEHRRSSE DESKKNAKRD FRDIPHEDVS
1410 1420 1430 1440 1450
DEEETEDGSR SRRQSTSSTI SNVTAKERKE KSGKTPLRIV PEPTGTPLLS
1460 1470 1480 1490 1500
PKILSPKHLS PKTSTSSTKR SSISDHENLI SPRQRNRTTS STSTATTSSK
1510 1520 1530 1540 1550
HEALSIPEKP LSPPVTAKSS VSSIDDPSIR DEFSMNSAAD SPMSTTGRPM
1560 1570 1580 1590 1600
VLTKAAMKAF NSTPPKKKNS SSGQHDSSSG SSSDSSSSDG STSSDDSSDD
1610 1620 1630 1640 1650
EVPKQTEPVT SIPVVASDNG SPENVVVETP SIVSQTPREP EPFTISEQSS
1660 1670 1680 1690 1700
ESEPEAVPEC PEASVEPQME TSQNVEPVSE EHEDSHEHGD SEVAVESQQQ
1710 1720 1730 1740 1750
PLEHQEEKEE LENKILDVAA EHHEEQVQGD EDSVESSIPA PSDEPDPVTQ
1760 1770 1780 1790 1800
AQEKSAHTLI SDQETDQAVQ SIFDEEEADE FPQYPDFGIS TNEKEVSGKD
1810 1820 1830 1840 1850
PHNIKPTEPL NNGHTDLLFS PSSSAHASEK QSTKSEDDME EDSELVVMEK
1860 1870 1880 1890 1900
EVPMEQVIAQ EVHVPSEPSP MEEEVKLETS PVPKEEPIKM EESPEQTPTP
1910 1920 1930 1940 1950
DLISNNESQD TPGAVNNHLH ENHDAVQTPI QLQPASQHQV AQPSPRPAVA
1960 1970 1980 1990 2000
PDSQQNGPVL VSQQSQPSPM SSQQSDMAQN LILSSKDIND LAAKLHKNPE
2010 2020 2030 2040 2050
ALAQATRGDC SGIFQHLLLH AQGNGQNMTP EMLQLKAAFF AQQQENEANQ
2060 2070 2080 2090 2100
MMQAKMKQQT INKDRIKEQE RVKRMYEENE RKVEEDRREK QRKEEERQRL
2110 2120 2130 2140 2150
AAATAAATMA TQKAAEALKQ KQEVPRHGFQ HVLSMMTPEA RSLYEQFPGL
2160 2170 2180 2190 2200
SSYINRDSIG ATNGVLHLPT QSIQRPSSTA STSSNPPKAP LQPSASVNQN
2210 2220 2230 2240 2250
TIDPAEIEEI RVQRWFYKHF PMVWTGRLAL KSTEAMINLH LINGSETFLN
2260 2270 2280 2290 2300
DVLGRQVTEE NPRRDSVKIL QRLRLDNGQV EHIYRILTNP EYACCLALSS
2310 2320 2330 2340 2350
VNNIENLKEN DTNLKSHFID YLINKKIAGI SSLGEVETKF KSARVHVFAP
2360 2370 2380 2390 2400
GEIVNRYLSE LATSLHDYLQ NTDTRYLLIV FTNDKADPNM TGPPSVASLA

VPPVSST
Length:2,407
Mass (Da):269,334
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2064D0266DA1DA5
GO
Isoform aImported (identifier: G5EGK6-2) [UniParc]FASTAAdd to basket
Also known as: din-1LD1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1568-1763: Missing.

Show »
Length:2,211
Mass (Da):248,382
Checksum:i8B568DE411EC7F87
GO
Isoform cImported (identifier: G5EGK6-3) [UniParc]FASTAAdd to basket
Also known as: din-1LB1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     118-132: Missing.

Show »
Length:2,392
Mass (Da):267,682
Checksum:i57487CA1F525527B
GO
Isoform dImported (identifier: G5EGK6-4) [UniParc]FASTAAdd to basket
Also known as: din-1S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-2218: MVQVPSTNTV...EIRVQRWFYK → MSAEEAATVM...KIVDEQSFSQ

Show »
Length:567
Mass (Da):61,329
Checksum:iB3719581DC126853
GO
Isoform eImported (identifier: G5EGK6-5) [UniParc]FASTAAdd to basket
Also known as: din-1LC1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-306: Missing.

Show »
Length:2,101
Mass (Da):234,745
Checksum:i1278C9E064AB04C9
GO
Isoform fImported (identifier: G5EGK6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-393: Missing.

Show »
Length:2,014
Mass (Da):224,677
Checksum:i4ECE10A03B866A46
GO
Isoform gImported (identifier: G5EGK6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2221: Missing.

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Length:186
Mass (Da):20,828
Checksum:i159D7D40B3C4723A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0578611 – 2221Missing in isoform g. CuratedAdd BLAST2221
Alternative sequenceiVSP_0578621 – 2218MVQVP…RWFYK → MSAEEAATVMAVASSDPNPP ATSTVDLAAMLQQLQAAQAA QAAQQVPVVTTASTPNPLSN LETLLSTASLANLATGGALN PLSMLALTSSLNQSSPVYQG IARVLLTMNMGQMLATHQTS ELLATMNQQETLMALLAARN GLPFAMPQQNQQPQMPAQGG FAIPTVLPHMSLKRNAKDQL SVGGVSDRKKSCPLHAMIGQ GQQPPPPQQPMQAVAPAPPR SPSPPRKSMFENLPPEMKEK NEMFRKEILRRLDIILLEEL GAEDEEDQKPDLKQIPTSEE DTDDSKADSMGAEGSAFRRI LSRSSTMGNNSGSPSASGTT SPSTSSSISSGPDSPPLEGE PLNSEFMDMLTEVAQKHREQ SNTDALSAKIVDEQSFSQ in isoform d. CuratedAdd BLAST2218
Alternative sequenceiVSP_0578631 – 393Missing in isoform f. CuratedAdd BLAST393
Alternative sequenceiVSP_0578641 – 306Missing in isoform e. CuratedAdd BLAST306
Alternative sequenceiVSP_057865118 – 132Missing in isoform c. CuratedAdd BLAST15
Alternative sequenceiVSP_0578661568 – 1763Missing in isoform a. CuratedAdd BLAST196

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAB54211.2
BX284602 Genomic DNA Translation: CAB54210.3
BX284602 Genomic DNA Translation: CAD57694.1
BX284602 Genomic DNA Translation: CAD57693.1
BX284602 Genomic DNA Translation: CAH60796.1
BX284602 Genomic DNA Translation: CBW48357.1
BX284602 Genomic DNA Translation: CBW48356.1

Protein sequence database of the Protein Information Resource

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PIRi
T20531
T20532

NCBI Reference Sequences

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RefSeqi
NP_001022068.1, NM_001026897.3
NP_001254306.1, NM_001267377.1 [G5EGK6-6]
NP_001254307.1, NM_001267378.1 [G5EGK6-7]
NP_496484.3, NM_064083.5 [G5EGK6-2]
NP_496485.2, NM_064084.6 [G5EGK6-1]
NP_871901.1, NM_182101.3 [G5EGK6-3]
NP_871902.1, NM_182102.4 [G5EGK6-4]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F07A11.6a.1; F07A11.6a.1; WBGene00008549 [G5EGK6-2]
F07A11.6b.1; F07A11.6b.1; WBGene00008549 [G5EGK6-1]
F07A11.6c.1; F07A11.6c.1; WBGene00008549 [G5EGK6-3]
F07A11.6d.1; F07A11.6d.1; WBGene00008549 [G5EGK6-4]
F07A11.6d.2; F07A11.6d.2; WBGene00008549 [G5EGK6-4]
F07A11.6e.1; F07A11.6e.1; WBGene00008549 [G5EGK6-5]
F07A11.6f.1; F07A11.6f.1; WBGene00008549 [G5EGK6-6]
F07A11.6g.1; F07A11.6g.1; WBGene00008549 [G5EGK6-7]
F07A11.6g.2; F07A11.6g.2; WBGene00008549 [G5EGK6-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
174782

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F07A11.6

UCSC genome browser

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UCSCi
F07A11.6c, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAB54211.2
BX284602 Genomic DNA Translation: CAB54210.3
BX284602 Genomic DNA Translation: CAD57694.1
BX284602 Genomic DNA Translation: CAD57693.1
BX284602 Genomic DNA Translation: CAH60796.1
BX284602 Genomic DNA Translation: CBW48357.1
BX284602 Genomic DNA Translation: CBW48356.1
PIRiT20531
T20532
RefSeqiNP_001022068.1, NM_001026897.3
NP_001254306.1, NM_001267377.1 [G5EGK6-6]
NP_001254307.1, NM_001267378.1 [G5EGK6-7]
NP_496484.3, NM_064083.5 [G5EGK6-2]
NP_496485.2, NM_064084.6 [G5EGK6-1]
NP_871901.1, NM_182101.3 [G5EGK6-3]
NP_871902.1, NM_182102.4 [G5EGK6-4]

3D structure databases

SMRiG5EGK6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F07A11.6b

Proteomic databases

EPDiG5EGK6
PaxDbiG5EGK6
PeptideAtlasiG5EGK6
PRIDEiG5EGK6

Genome annotation databases

EnsemblMetazoaiF07A11.6a.1; F07A11.6a.1; WBGene00008549 [G5EGK6-2]
F07A11.6b.1; F07A11.6b.1; WBGene00008549 [G5EGK6-1]
F07A11.6c.1; F07A11.6c.1; WBGene00008549 [G5EGK6-3]
F07A11.6d.1; F07A11.6d.1; WBGene00008549 [G5EGK6-4]
F07A11.6d.2; F07A11.6d.2; WBGene00008549 [G5EGK6-4]
F07A11.6e.1; F07A11.6e.1; WBGene00008549 [G5EGK6-5]
F07A11.6f.1; F07A11.6f.1; WBGene00008549 [G5EGK6-6]
F07A11.6g.1; F07A11.6g.1; WBGene00008549 [G5EGK6-7]
F07A11.6g.2; F07A11.6g.2; WBGene00008549 [G5EGK6-7]
GeneIDi174782
KEGGicel:CELE_F07A11.6
UCSCiF07A11.6c, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
174782
WormBaseiF07A11.6a ; CE37499 ; WBGene00008549 ; din-1
F07A11.6b ; CE32618 ; WBGene00008549 ; din-1
F07A11.6c ; CE32619 ; WBGene00008549 ; din-1
F07A11.6d ; CE03148 ; WBGene00008549 ; din-1
F07A11.6e ; CE37500 ; WBGene00008549 ; din-1
F07A11.6f ; CE45315 ; WBGene00008549 ; din-1
F07A11.6g ; CE45296 ; WBGene00008549 ; din-1

Phylogenomic databases

eggNOGiKOG0112, Eukaryota
InParanoidiG5EGK6
OMAiFRDIPHE
OrthoDBi367857at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EGK6

Gene expression databases

BgeeiWBGene00008549, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di2.40.290.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR016194, SPOC-like_C_dom_sf
IPR012921, SPOC_C
IPR010912, SPOC_met
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
PF07744, SPOC, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF100939, SSF100939, 1 hit
SSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit
PS50917, SPOC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIN1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EGK6
Secondary accession number(s): E1B6R6
, G5EBT0, G5ED50, G5EDA4, G5EEE3, Q8I124
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: December 14, 2011
Last modified: June 2, 2021
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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