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Entry version 72 (13 Nov 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Tyrosine-protein kinase receptor cam-1

Gene

cam-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom-2 and cwn-1 (PubMed:17942487, PubMed:25029443). Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development (PubMed:10476968, PubMed:9165130, PubMed:9475729, PubMed:14651925). Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2 (PubMed:25373777). In addition, plays a role in ASI sensory neuron positioning and functions (PubMed:10556063). Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth (PubMed:10476968, PubMed:14651925). Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring by controlling axon guidance of SIA and SIB neurons (PubMed:19855022). Involved in synapse plasticity by regulating delivery and/or stabilization of acetylcholine receptor acr-16 at post-synaptic membrane sites and the distribution of synaptic vesicles at pre-synaptic release sites (PubMed:15944127). Probably by acting as a receptor for Wnt ligands cwn-1 and cwn-2, negatively regulates developmental neurite pruning of AIM neurons (PubMed:19561603). Plays a role in ALM neuron polarity (PubMed:25917219). By binding Wnt ligands mom-2, cwn-1 and egl-20 and thereby restricting their availability, negatively regulates Wnt signaling. This mechanism is involved in HSN neuron and QR neuronal descendent migration, and in vulva development (PubMed:15371357, PubMed:17942487). Involved in dauer formation, locomotion, tail morphology and egg-laying (PubMed:10556063, PubMed:9475729, PubMed:14504222). May be involved in distal tip cell (DTC) migration during the development of the posterior gonad (PubMed:10556063).14 Publications
Isoform a: Involved in the positioning of the nerve ring.1 Publication
Isoform b: Involved in the positioning of the nerve ring.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Can use both Mg2+ and Mn2+ in vitro and shows higher activity with Mn2+ but Mg2+ is likely to be the in vivo cofactor.Curated

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Autophosphorylation gives similar KM values for ATP.1 Publication
  1. KM=3.53 mM for ATP (in the presence of Mg2+ at 20 degrees Celsius)1 Publication
  2. KM=0.45 mM for ATP (in the presence of Mn2+ at 20 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei624ATPPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei726Proton acceptorPROSITE-ProRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi596 – 604ATPPROSITE-ProRule annotation9

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
    Biological processNeurogenesis, Wnt signaling pathway
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-CEL-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Tyrosine-protein kinase receptor cam-1Curated (EC:2.7.10.1UniRule annotation1 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:cam-1Imported
    Synonyms:kin-8Imported
    ORF Names:C01G6.8Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

    Organism-specific databases

    WormBase

    More...
    WormBasei
    C01G6.8a ; CE32563 ; WBGene00000289 ; cam-1
    C01G6.8b ; CE24774 ; WBGene00000289 ; cam-1
    C01G6.8c ; CE39126 ; WBGene00000289 ; cam-1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 466ExtracellularSequence analysisAdd BLAST466
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
    Topological domaini488 – 928CytoplasmicSequence analysisAdd BLAST441

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Membrane, Synapse

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    RNAi-mediated knockdown in a lin-17 n671 mutant background causes 8 percent of animals to produce more than 22 vulval cells (overinduction).1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi265C → Y in sa692; constitutive dauer formation at high temperature and impaired migration of ALM, BDU, CAN and HSN neurons, and QR neuroblast descendants during development. Moderate defect in ALM polarity. 3 Publications1
    Mutagenesisi599G → C or D: Moderate loss of kinase activity. 1 Publication1
    Mutagenesisi624 – 625KK → MM: Probable loss of kinase activity. Abnormal locomotion. No increase in dauer formation. 1 Publication2
    Mutagenesisi624 – 625KK → RR: Probable loss of kinase activity. Increased number of interconnected AIM neurons when expressed in a wild type background. 1 Publication2
    Mutagenesisi624K → R: No effect on kinase activity. 1 Publication1
    Mutagenesisi713G → R in cw82; mild defect in ALM polarity. 1 Publication1
    Mutagenesisi744D → N: Severe loss of kinase activity. 1 Publication1
    Mutagenesisi790G → E in xd13; mild defect in ALM polarity and in QR neuroblast descendant migration. 2 Publications1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004345571 – 928Tyrosine-protein kinase receptor cam-1CuratedAdd BLAST928

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi46N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi59 ↔ 110PROSITE-ProRule annotation
    Glycosylationi91N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi120N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Disulfide bondi205 ↔ 272PROSITE-ProRule annotation
    Disulfide bondi213 ↔ 265PROSITE-ProRule annotation
    Glycosylationi226N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Disulfide bondi256 ↔ 296PROSITE-ProRule annotation
    Disulfide bondi284 ↔ 329PROSITE-ProRule annotation
    Disulfide bondi288 ↔ 320PROSITE-ProRule annotation
    Disulfide bondi354 ↔ 429PROSITE-ProRule annotation
    Disulfide bondi375 ↔ 413PROSITE-ProRule annotation
    Disulfide bondi401 ↔ 424PROSITE-ProRule annotation

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Autophosphorylated at tyrosine residues which are probably located in the activation loop (residues 724-732). Autophosphorylation does not increase kinase activity in vitro.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    G5EGK5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    G5EGK5

    PeptideAtlas

    More...
    PeptideAtlasi
    G5EGK5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in AIM neurons and in several head neurons (PubMed:19561603). Isoform a is expressed in some head muscles and in several head neurons. Isoform b is expressed in several head neurons, in procorpus and isthmus pharyngeal muscles, body wall muscles, and to a lower extent in intestine, seam cells (V cells) and distal tip cells (PubMed:10556063, PubMed:10476968, PubMed:15944127).4 Publications

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expressed in 200-cell stage embryo (PubMed:10476968). Expressed predominantly in QR neuroblast descendants and to a lesser extent in QL neuroblast descendants during larval stage (PubMed:25373777).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    WBGene00000289 Expressed in 12 organ(s), highest expression level in multi-cellular organism

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    G5EGK5, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    6239.C01G6.8a

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    G5EGK5

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 126Ig-like C2-typePROSITE-ProRule annotationAdd BLAST91
    Domaini200 – 332FZPROSITE-ProRule annotationAdd BLAST133
    Domaini353 – 429KringlePROSITE-ProRule annotationAdd BLAST77
    Domaini590 – 870Protein kinasePROSITE-ProRule annotationAdd BLAST281

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The FZ domain is involved in binding to Wnt ligands egl-20, cwn-1 and mom-2 (PubMed:15371357, PubMed:17942487). The domain is required for the final positioning of migrating ALM, CAN, BDU and HSN neurons, and maybe QR neuroblast descendants during development and for neurite pruning of AIM neurons (PubMed:14651925, PubMed:19561603). Required for the establishment of ALM polarity (PubMed:25917219).6 Publications
    The domain is required to establish correct polarity in ALM neurons (PubMed:25917219). May play a role in QR neuroblast descendant migration (PubMed:25373777). The kinase domain is dispensable for ALM, CAN, BDU and HSN neuron migration, V cell asymmetric division, acr-16 localization, for the positioning of the nerve ring and probably for the negative regulation of neurite pruning of AIM neurons (PubMed:14651925, PubMed:15944127, PubMed:19855022, PubMed:19561603).6 Publications
    The cytoplasmic domain is required for the negative regulation of neurite pruning of AIM neurons.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.UniRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Kringle, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1026 Eukaryota
    ENOG410YGKQ LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000166767

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000021825

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    G5EGK5

    KEGG Orthology (KO)

    More...
    KOi
    K08252

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ECWHEQS

    Database of Orthologous Groups

    More...
    OrthoDBi
    471114at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    G5EGK5

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd07459 CRD_TK_ROR_like, 1 hit
    cd00108 KR, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.2000.10, 1 hit
    2.40.20.10, 1 hit
    2.60.40.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020067 Frizzled_dom
    IPR036790 Frizzled_dom_sf
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR011009 Kinase-like_dom_sf
    IPR000001 Kringle
    IPR013806 Kringle-like
    IPR018056 Kringle_CS
    IPR038178 Kringle_sf
    IPR000719 Prot_kinase_dom
    IPR017441 Protein_kinase_ATP_BS
    IPR041775 Ror-like_CRD
    IPR001245 Ser-Thr/Tyr_kinase_cat_dom
    IPR008266 Tyr_kinase_AS
    IPR020635 Tyr_kinase_cat_dom
    IPR016247 Tyr_kinase_rcpt_ROR

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07679 I-set, 1 hit
    PF00051 Kringle, 1 hit
    PF07714 Pkinase_Tyr, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000624 TyrPK_TMrec_ROR, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00109 TYRKINASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00409 IG, 1 hit
    SM00408 IGc2, 1 hit
    SM00130 KR, 1 hit
    SM00219 TyrKc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48726 SSF48726, 1 hit
    SSF56112 SSF56112, 1 hit
    SSF57440 SSF57440, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50038 FZ, 1 hit
    PS50835 IG_LIKE, 1 hit
    PS00021 KRINGLE_1, 1 hit
    PS50070 KRINGLE_2, 1 hit
    PS00107 PROTEIN_KINASE_ATP, 1 hit
    PS50011 PROTEIN_KINASE_DOM, 1 hit
    PS00109 PROTEIN_KINASE_TYR, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform aImported (identifier: G5EGK5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSPRPEDDDL VIEPADDEGL HYGNASMEGT STGQRPYIRL TSQLRNATKS
    60 70 80 90 100
    SGDEVRFKCE ALGTPPLKFI WLKNNGPVEK TKRVKIRDKE NSSRLVITQL
    110 120 130 140 150
    DVLDSGYYQC IVSNPAASVN TTSVLRVNNV PDAVKLSQKK GSHHSTKHIA
    160 170 180 190 200
    FDEYEDYEMM DRGRLPDEED ADLYRVPDSA AGSNYAPVAV SERWLDGIKY
    210 220 230 240 250
    RVGDCVQYRG EACRQYLSNK FVMMTNESRE EMYDIDRNLR AAMLFINGAP
    260 270 280 290 300
    TISQKCRQLS QAVACHHMYK VCESDSNNQI VSICKHDCDV IQNDECPSEL
    310 320 330 340 350
    ALAAQHELVG DTPKALFPLC SRLSSTSNCI PVMSTALQSS PVAEVNRGHL
    360 370 380 390 400
    THWCYVNSGT QYEGTVAQTS SGKQCAPWID STSRDFNVHR FPELMNSKNY
    410 420 430 440 450
    CRNPGGKKSR PWCYSKPMGQ EEYCDVPQCP SDMYPHLNDK KVEGSTKGGV
    460 470 480 490 500
    SESVTALWDS LDPTMQVALV GGGVFFSLLL LLLFCCACCC RAKKKSQKTR
    510 520 530 540 550
    HQNAHCSSAP SVINSAANSA YYRKLNGTST PIMGRVPPHV EMTSLLPSAQ
    560 570 580 590 600
    HLGPPPYPMD QHLQQARRFP SQEPIDDNSY KVFEITPSQL SVREKIGEGQ
    610 620 630 640 650
    FGVVHSGIYT SGLFAPEPMA VAVKKCRHDA TNAERAQLEQ EIRAVATFDH
    660 670 680 690 700
    PNVIKLIGVC YMDNSLLAVF EYMVHGDLHE LLKVRVPPAD HDMGGITEAN
    710 720 730 740 750
    AEFLYIATQI ALGMEYLASM SFVHRDLATR NCLVGDTRTI KIADFGLMRT
    760 770 780 790 800
    SYGSDYYKML HRSWMPVRWM SKEAIEQGRF SEASDVWSFG VTLWEIWSFG
    810 820 830 840 850
    RQPYEGASNQ QVIELVANRH LLECPHNCPT NIYSLMVECW HENIERRPTF
    860 870 880 890 900
    SEIRSRLQSW SLASPAHSIL QQHNNRAGSH SGSSGAGRPP THQRGYPSQK
    910 920
    LHRRVEGASP LMKRHDANYA YSEDGDSD
    Length:928
    Mass (Da):103,864
    Last modified:December 14, 2011 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF13B8C9BCAB30D20
    GO
    Isoform bImported (identifier: G5EGK5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: Missing.

    Show »
    Length:902
    Mass (Da):101,039
    Checksum:i2A03D76D07C552B5
    GO
    Isoform cImported (identifier: G5EGK5-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-159: Missing.

    Note: No experimental confirmation available.Curated
    Show »
    Length:769
    Mass (Da):86,083
    Checksum:i2EE4BE65BCC9CF79
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0579541 – 159Missing in isoform c. CuratedAdd BLAST159
    Alternative sequenceiVSP_0579551 – 26Missing in isoform b. CuratedAdd BLAST26

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ132946 mRNA Translation: CAC29084.1
    AJ132947 mRNA Translation: CAC29085.1
    BX284602 Genomic DNA Translation: CAA84639.2
    BX284602 Genomic DNA Translation: CAD36478.1
    BX284602 Genomic DNA Translation: CAJ34992.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T18840

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001021907.1, NM_001026736.4 [G5EGK5-1]
    NP_001021908.1, NM_001026737.3 [G5EGK5-2]
    NP_001033327.1, NM_001038238.2 [G5EGK5-3]

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    C01G6.8a.1; C01G6.8a.1; WBGene00000289 [G5EGK5-1]
    C01G6.8b.1; C01G6.8b.1; WBGene00000289 [G5EGK5-2]
    C01G6.8c.1; C01G6.8c.1; WBGene00000289 [G5EGK5-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    174473

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    cel:CELE_C01G6.8

    UCSC genome browser

    More...
    UCSCi
    C01G6.8a c. elegans

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ132946 mRNA Translation: CAC29084.1
    AJ132947 mRNA Translation: CAC29085.1
    BX284602 Genomic DNA Translation: CAA84639.2
    BX284602 Genomic DNA Translation: CAD36478.1
    BX284602 Genomic DNA Translation: CAJ34992.1
    PIRiT18840
    RefSeqiNP_001021907.1, NM_001026736.4 [G5EGK5-1]
    NP_001021908.1, NM_001026737.3 [G5EGK5-2]
    NP_001033327.1, NM_001038238.2 [G5EGK5-3]

    3D structure databases

    SMRiG5EGK5
    ModBaseiSearch...

    Protein-protein interaction databases

    IntActiG5EGK5, 3 interactors
    STRINGi6239.C01G6.8a

    Proteomic databases

    EPDiG5EGK5
    PaxDbiG5EGK5
    PeptideAtlasiG5EGK5

    Genome annotation databases

    EnsemblMetazoaiC01G6.8a.1; C01G6.8a.1; WBGene00000289 [G5EGK5-1]
    C01G6.8b.1; C01G6.8b.1; WBGene00000289 [G5EGK5-2]
    C01G6.8c.1; C01G6.8c.1; WBGene00000289 [G5EGK5-3]
    GeneIDi174473
    KEGGicel:CELE_C01G6.8
    UCSCiC01G6.8a c. elegans

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    174473
    WormBaseiC01G6.8a ; CE32563 ; WBGene00000289 ; cam-1
    C01G6.8b ; CE24774 ; WBGene00000289 ; cam-1
    C01G6.8c ; CE39126 ; WBGene00000289 ; cam-1

    Phylogenomic databases

    eggNOGiKOG1026 Eukaryota
    ENOG410YGKQ LUCA
    GeneTreeiENSGT00940000166767
    HOGENOMiHOG000021825
    InParanoidiG5EGK5
    KOiK08252
    OMAiECWHEQS
    OrthoDBi471114at2759
    PhylomeDBiG5EGK5

    Enzyme and pathway databases

    ReactomeiR-CEL-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:G5EGK5

    Gene expression databases

    BgeeiWBGene00000289 Expressed in 12 organ(s), highest expression level in multi-cellular organism

    Family and domain databases

    CDDicd07459 CRD_TK_ROR_like, 1 hit
    cd00108 KR, 1 hit
    Gene3Di1.10.2000.10, 1 hit
    2.40.20.10, 1 hit
    2.60.40.10, 1 hit
    InterProiView protein in InterPro
    IPR020067 Frizzled_dom
    IPR036790 Frizzled_dom_sf
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR011009 Kinase-like_dom_sf
    IPR000001 Kringle
    IPR013806 Kringle-like
    IPR018056 Kringle_CS
    IPR038178 Kringle_sf
    IPR000719 Prot_kinase_dom
    IPR017441 Protein_kinase_ATP_BS
    IPR041775 Ror-like_CRD
    IPR001245 Ser-Thr/Tyr_kinase_cat_dom
    IPR008266 Tyr_kinase_AS
    IPR020635 Tyr_kinase_cat_dom
    IPR016247 Tyr_kinase_rcpt_ROR
    PfamiView protein in Pfam
    PF07679 I-set, 1 hit
    PF00051 Kringle, 1 hit
    PF07714 Pkinase_Tyr, 1 hit
    PIRSFiPIRSF000624 TyrPK_TMrec_ROR, 1 hit
    PRINTSiPR00109 TYRKINASE
    SMARTiView protein in SMART
    SM00409 IG, 1 hit
    SM00408 IGc2, 1 hit
    SM00130 KR, 1 hit
    SM00219 TyrKc, 1 hit
    SUPFAMiSSF48726 SSF48726, 1 hit
    SSF56112 SSF56112, 1 hit
    SSF57440 SSF57440, 1 hit
    PROSITEiView protein in PROSITE
    PS50038 FZ, 1 hit
    PS50835 IG_LIKE, 1 hit
    PS00021 KRINGLE_1, 1 hit
    PS50070 KRINGLE_2, 1 hit
    PS00107 PROTEIN_KINASE_ATP, 1 hit
    PS50011 PROTEIN_KINASE_DOM, 1 hit
    PS00109 PROTEIN_KINASE_TYR, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAM1_CAEEL
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EGK5
    Secondary accession number(s): G5ECA5, Q38G54
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
    Last sequence update: December 14, 2011
    Last modified: November 13, 2019
    This is version 72 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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