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Entry version 80 (29 Sep 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Tyrosine-protein kinase receptor cam-1

Gene

cam-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom-2 and cwn-1 (PubMed:17942487, PubMed:25029443).

Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development (PubMed:10476968, PubMed:9165130, PubMed:9475729, PubMed:14651925).

Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2 (PubMed:25373777).

In addition, plays a role in ASI sensory neuron positioning and functions (PubMed:10556063).

Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth (PubMed:10476968, PubMed:14651925).

Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring by controlling axon guidance of SIA and SIB neurons (PubMed:19855022).

Involved in synapse plasticity by regulating delivery and/or stabilization of acetylcholine receptor acr-16 at post-synaptic membrane sites and the distribution of synaptic vesicles at pre-synaptic release sites (PubMed:15944127).

Probably by acting as a receptor for Wnt ligands cwn-1 and cwn-2, negatively regulates developmental neurite pruning of AIM neurons (PubMed:19561603).

Plays a role in ALM neuron polarity (PubMed:25917219).

By binding Wnt ligands mom-2, cwn-1 and egl-20 and thereby restricting their availability, negatively regulates Wnt signaling. This mechanism is involved in HSN neuron and QR neuronal descendent migration, and in vulva development (PubMed:15371357, PubMed:17942487).

Involved in dauer formation, locomotion, tail morphology and egg-laying (PubMed:10556063, PubMed:9475729, PubMed:14504222).

May be involved in distal tip cell (DTC) migration during the development of the posterior gonad (PubMed:10556063).

14 Publications

Involved in the positioning of the nerve ring.

1 Publication

Involved in the positioning of the nerve ring.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Can use both Mg2+ and Mn2+ in vitro and shows higher activity with Mn2+ but Mg2+ is likely to be the in vivo cofactor.Curated

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Autophosphorylation gives similar KM values for ATP.1 Publication
  1. KM=3.53 mM for ATP (in the presence of Mg2+ at 20 degrees Celsius)1 Publication
  2. KM=0.45 mM for ATP (in the presence of Mn2+ at 20 degrees Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei624ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei726Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi596 – 604ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processNeurogenesis, Wnt signaling pathway
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase receptor cam-1Curated (EC:2.7.10.1UniRule annotation1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cam-1Imported
Synonyms:kin-8Imported
ORF Names:C01G6.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C01G6.8a ; CE32563 ; WBGene00000289 ; cam-1
C01G6.8b ; CE24774 ; WBGene00000289 ; cam-1
C01G6.8c ; CE39126 ; WBGene00000289 ; cam-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 466ExtracellularSequence analysisAdd BLAST466
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 928CytoplasmicSequence analysisAdd BLAST441

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in a lin-17 n671 mutant background causes 8 percent of animals to produce more than 22 vulval cells (overinduction).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi265C → Y in sa692; constitutive dauer formation at high temperature and impaired migration of ALM, BDU, CAN and HSN neurons, and QR neuroblast descendants during development. Moderate defect in ALM polarity. 3 Publications1
Mutagenesisi599G → C or D: Moderate loss of kinase activity. 1 Publication1
Mutagenesisi624 – 625KK → MM: Probable loss of kinase activity. Abnormal locomotion. No increase in dauer formation. 1 Publication2
Mutagenesisi624 – 625KK → RR: Probable loss of kinase activity. Increased number of interconnected AIM neurons when expressed in a wild type background. 1 Publication2
Mutagenesisi624K → R: No effect on kinase activity. 1 Publication1
Mutagenesisi713G → R in cw82; mild defect in ALM polarity. 1 Publication1
Mutagenesisi744D → N: Severe loss of kinase activity. 1 Publication1
Mutagenesisi790G → E in xd13; mild defect in ALM polarity and in QR neuroblast descendant migration. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004345571 – 928Tyrosine-protein kinase receptor cam-1CuratedAdd BLAST928

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi46N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi59 ↔ 110PROSITE-ProRule annotation
Glycosylationi91N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi120N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi205 ↔ 272PROSITE-ProRule annotation
Disulfide bondi213 ↔ 265PROSITE-ProRule annotation
Glycosylationi226N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi256 ↔ 296PROSITE-ProRule annotation
Disulfide bondi284 ↔ 329PROSITE-ProRule annotation
Disulfide bondi288 ↔ 320PROSITE-ProRule annotation
Disulfide bondi354 ↔ 429PROSITE-ProRule annotation
Disulfide bondi375 ↔ 413PROSITE-ProRule annotation
Disulfide bondi401 ↔ 424PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated at tyrosine residues which are probably located in the activation loop (residues 724-732). Autophosphorylation does not increase kinase activity in vitro.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EGK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EGK5

PeptideAtlas

More...
PeptideAtlasi
G5EGK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in AIM neurons and in several head neurons (PubMed:19561603). Isoform a is expressed in some head muscles and in several head neurons. Isoform b is expressed in several head neurons, in procorpus and isthmus pharyngeal muscles, body wall muscles, and to a lower extent in intestine, seam cells (V cells) and distal tip cells (PubMed:10556063, PubMed:10476968, PubMed:15944127).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in 200-cell stage embryo (PubMed:10476968). Expressed predominantly in QR neuroblast descendants and to a lesser extent in QL neuroblast descendants during larval stage (PubMed:25373777).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000289, Expressed in multi-cellular organism and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5EGK5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C01G6.8a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EGK5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 126Ig-like C2-typePROSITE-ProRule annotationAdd BLAST91
Domaini200 – 332FZPROSITE-ProRule annotationAdd BLAST133
Domaini353 – 429KringlePROSITE-ProRule annotationAdd BLAST77
Domaini590 – 870Protein kinasePROSITE-ProRule annotationAdd BLAST281

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni873 – 928DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi873 – 888Polar residuesSequence analysisAdd BLAST16
Compositional biasi906 – 922Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FZ domain is involved in binding to Wnt ligands egl-20, cwn-1 and mom-2 (PubMed:15371357, PubMed:17942487). The domain is required for the final positioning of migrating ALM, CAN, BDU and HSN neurons, and maybe QR neuroblast descendants during development and for neurite pruning of AIM neurons (PubMed:14651925, PubMed:19561603). Required for the establishment of ALM polarity (PubMed:25917219).6 Publications
The domain is required to establish correct polarity in ALM neurons (PubMed:25917219). May play a role in QR neuroblast descendant migration (PubMed:25373777). The kinase domain is dispensable for ALM, CAN, BDU and HSN neuron migration, V cell asymmetric division, acr-16 localization, for the positioning of the nerve ring and probably for the negative regulation of neurite pruning of AIM neurons (PubMed:14651925, PubMed:15944127, PubMed:19855022, PubMed:19561603).6 Publications
The cytoplasmic domain is required for the negative regulation of neurite pruning of AIM neurons.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1026, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166767

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EGK5

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECWHEQS

Database of Orthologous Groups

More...
OrthoDBi
471114at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EGK5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07459, CRD_TK_ROR_like, 1 hit
cd00108, KR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR041775, Ror-like_CRD
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016247, Tyr_kinase_rcpt_ROR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 1 hit
PF00051, Kringle, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000624, TyrPK_TMrec_ROR, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00130, KR, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF56112, SSF56112, 1 hit
SSF57440, SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038, FZ, 1 hit
PS50835, IG_LIKE, 1 hit
PS00021, KRINGLE_1, 1 hit
PS50070, KRINGLE_2, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: G5EGK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPRPEDDDL VIEPADDEGL HYGNASMEGT STGQRPYIRL TSQLRNATKS
60 70 80 90 100
SGDEVRFKCE ALGTPPLKFI WLKNNGPVEK TKRVKIRDKE NSSRLVITQL
110 120 130 140 150
DVLDSGYYQC IVSNPAASVN TTSVLRVNNV PDAVKLSQKK GSHHSTKHIA
160 170 180 190 200
FDEYEDYEMM DRGRLPDEED ADLYRVPDSA AGSNYAPVAV SERWLDGIKY
210 220 230 240 250
RVGDCVQYRG EACRQYLSNK FVMMTNESRE EMYDIDRNLR AAMLFINGAP
260 270 280 290 300
TISQKCRQLS QAVACHHMYK VCESDSNNQI VSICKHDCDV IQNDECPSEL
310 320 330 340 350
ALAAQHELVG DTPKALFPLC SRLSSTSNCI PVMSTALQSS PVAEVNRGHL
360 370 380 390 400
THWCYVNSGT QYEGTVAQTS SGKQCAPWID STSRDFNVHR FPELMNSKNY
410 420 430 440 450
CRNPGGKKSR PWCYSKPMGQ EEYCDVPQCP SDMYPHLNDK KVEGSTKGGV
460 470 480 490 500
SESVTALWDS LDPTMQVALV GGGVFFSLLL LLLFCCACCC RAKKKSQKTR
510 520 530 540 550
HQNAHCSSAP SVINSAANSA YYRKLNGTST PIMGRVPPHV EMTSLLPSAQ
560 570 580 590 600
HLGPPPYPMD QHLQQARRFP SQEPIDDNSY KVFEITPSQL SVREKIGEGQ
610 620 630 640 650
FGVVHSGIYT SGLFAPEPMA VAVKKCRHDA TNAERAQLEQ EIRAVATFDH
660 670 680 690 700
PNVIKLIGVC YMDNSLLAVF EYMVHGDLHE LLKVRVPPAD HDMGGITEAN
710 720 730 740 750
AEFLYIATQI ALGMEYLASM SFVHRDLATR NCLVGDTRTI KIADFGLMRT
760 770 780 790 800
SYGSDYYKML HRSWMPVRWM SKEAIEQGRF SEASDVWSFG VTLWEIWSFG
810 820 830 840 850
RQPYEGASNQ QVIELVANRH LLECPHNCPT NIYSLMVECW HENIERRPTF
860 870 880 890 900
SEIRSRLQSW SLASPAHSIL QQHNNRAGSH SGSSGAGRPP THQRGYPSQK
910 920
LHRRVEGASP LMKRHDANYA YSEDGDSD
Length:928
Mass (Da):103,864
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF13B8C9BCAB30D20
GO
Isoform bImported (identifier: G5EGK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Show »
Length:902
Mass (Da):101,039
Checksum:i2A03D76D07C552B5
GO
Isoform cImported (identifier: G5EGK5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Show »
Length:769
Mass (Da):86,083
Checksum:i2EE4BE65BCC9CF79
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0579541 – 159Missing in isoform c. CuratedAdd BLAST159
Alternative sequenceiVSP_0579551 – 26Missing in isoform b. CuratedAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ132946 mRNA Translation: CAC29084.1
AJ132947 mRNA Translation: CAC29085.1
BX284602 Genomic DNA Translation: CAA84639.2
BX284602 Genomic DNA Translation: CAD36478.1
BX284602 Genomic DNA Translation: CAJ34992.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18840

NCBI Reference Sequences

More...
RefSeqi
NP_001021907.1, NM_001026736.4 [G5EGK5-1]
NP_001021908.1, NM_001026737.3 [G5EGK5-2]
NP_001033327.1, NM_001038238.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C01G6.8a.1; C01G6.8a.1; WBGene00000289 [G5EGK5-1]
C01G6.8b.1; C01G6.8b.1; WBGene00000289 [G5EGK5-2]
C01G6.8c.1; C01G6.8c.1; WBGene00000289 [G5EGK5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C01G6.8

UCSC genome browser

More...
UCSCi
C01G6.8a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132946 mRNA Translation: CAC29084.1
AJ132947 mRNA Translation: CAC29085.1
BX284602 Genomic DNA Translation: CAA84639.2
BX284602 Genomic DNA Translation: CAD36478.1
BX284602 Genomic DNA Translation: CAJ34992.1
PIRiT18840
RefSeqiNP_001021907.1, NM_001026736.4 [G5EGK5-1]
NP_001021908.1, NM_001026737.3 [G5EGK5-2]
NP_001033327.1, NM_001038238.2

3D structure databases

SMRiG5EGK5
ModBaseiSearch...

Protein-protein interaction databases

IntActiG5EGK5, 3 interactors
STRINGi6239.C01G6.8a

Proteomic databases

EPDiG5EGK5
PaxDbiG5EGK5
PeptideAtlasiG5EGK5

Genome annotation databases

EnsemblMetazoaiC01G6.8a.1; C01G6.8a.1; WBGene00000289 [G5EGK5-1]
C01G6.8b.1; C01G6.8b.1; WBGene00000289 [G5EGK5-2]
C01G6.8c.1; C01G6.8c.1; WBGene00000289 [G5EGK5-3]
GeneIDi174473
KEGGicel:CELE_C01G6.8
UCSCiC01G6.8a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174473
WormBaseiC01G6.8a ; CE32563 ; WBGene00000289 ; cam-1
C01G6.8b ; CE24774 ; WBGene00000289 ; cam-1
C01G6.8c ; CE39126 ; WBGene00000289 ; cam-1

Phylogenomic databases

eggNOGiKOG1026, Eukaryota
GeneTreeiENSGT00940000166767
InParanoidiG5EGK5
OMAiECWHEQS
OrthoDBi471114at2759
PhylomeDBiG5EGK5

Enzyme and pathway databases

ReactomeiR-CEL-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EGK5

Gene expression databases

BgeeiWBGene00000289, Expressed in multi-cellular organism and 12 other tissues

Family and domain databases

CDDicd07459, CRD_TK_ROR_like, 1 hit
cd00108, KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR041775, Ror-like_CRD
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016247, Tyr_kinase_rcpt_ROR
PfamiView protein in Pfam
PF07679, I-set, 1 hit
PF00051, Kringle, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PIRSFiPIRSF000624, TyrPK_TMrec_ROR, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00130, KR, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56112, SSF56112, 1 hit
SSF57440, SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038, FZ, 1 hit
PS50835, IG_LIKE, 1 hit
PS00021, KRINGLE_1, 1 hit
PS50070, KRINGLE_2, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAM1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EGK5
Secondary accession number(s): G5ECA5, Q38G54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: December 14, 2011
Last modified: September 29, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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