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Entry version 65 (12 Aug 2020)
Sequence version 1 (14 Dec 2011)
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Protein

Condensin complex subunit dpy-26

Gene

dpy-26

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners (PubMed:8939869, PubMed:8939870, PubMed:19119011, PubMed:2917714, PubMed:19781752). Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis (PubMed:19119011, PubMed:19781752). As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure (PubMed:19781752, PubMed:18198337). Plays a role in robust cytokinesis upon presence of chromatin obstructions (PubMed:23684975). Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization (PubMed:19119011, PubMed:8939870, PubMed:2917714, PubMed:19781752). As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites (PubMed:11937488).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Meiosis, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Condensin complex subunit dpy-26Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dpy-26Imported
ORF Names:C25G4.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C25G4.5 ; CE08398 ; WBGene00001085 ; dpy-26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Results in larval lethality in XX hermaphrodites; survivors exhibit shorter and stouter body morphology and are egg-laying defective (PubMed:2917714). Male animals are viable (PubMed:2917714). Higher percentage of spontaneous males through X chromosome non-disjunction (PubMed:2917714). Disrupts protein stability of dpy-27 (PubMed:8939870). Disrupts localization of dpy-28 and of capg-1 to the hermaphrodite X-chromosome (PubMed:18198337, PubMed:19119011). RNAi-mediated knockdown results in chromosome segregation defects in mitosis and meiosis (PubMed:19119011). In a sex-1 mutant background, leads to high embryonic lethality (PubMed:19119011).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004401741 – 1263Condensin complex subunit dpy-26Add BLAST1263

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EGE9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EGE9

PeptideAtlas

More...
PeptideAtlasi
G5EGE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryos and in somatic and germline tissues in L4 stage larvae (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001085, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the condensin I complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:19119011, PubMed:19781752). Within the complex, interacts with dpy-28, mix-1, smc-4 and capg-1 (PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:28301465).

Component of the dosage compensation complex, which consists of the condensin I-like components mix-1/SMC2 and dpy-27/SMC4, and the three non SMC subunits dpy-26, capg-1 and dpy-28 (PubMed:19119011, PubMed:19781752). Within the complex, interacts with dpy-27, dpy-28, mix-1 and capg-1 (PubMed:8939870, PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:9458050, PubMed:28301465). The interaction with dpy-27 is required for dpy-27 protein stability (PubMed:8939870).

Interacts with smcl-1 (PubMed:28301465).

7 Publications

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1271, Condensin I complex
CPX-1273, Condensin I-like dosage compensation complex

Protein interaction database and analysis system

More...
IntActi
G5EGE9, 5 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C25G4.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
G5EGE9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili691 – 725Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TG5K, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007170_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5EGE9

Identification of Orthologs from Complete Genome Data

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OMAi
FQKATKG

Database of Orthologous Groups

More...
OrthoDBi
257799at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EGE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVPSSSNVT GRRKRQVLDD DEDDGFRSTP LRKVRGTKKI RPADVVPETI
60 70 80 90 100
MTKIGAHIDD IVNKKKVGEL NCFEYKSPLE IHTIEDMIKA KASIQEMAVV
110 120 130 140 150
LEGAQCIIGY RVDRLHHDVR QIDSALSSGT VMRDSNGEEI HLTLESRKAK
160 170 180 190 200
KKMAVVDGMN GMLDFLNNMD DALTTTELDA DNDKNWKEDE ENIAGEPRID
210 220 230 240 250
FKANSKDVDA FLQRDIFPEK LIYALSIKRA TDLRADLLSD VSNYISADDT
260 270 280 290 300
AHDLKDANID WLRANPTFQK ATKGSVCNSS NSFHSLNYYG IHSPDGRTLM
310 320 330 340 350
LHNRIADKNA DDRFFTSDVS VSLVKNTRAL LTNSLDKKPR ILDNYLMLEV
360 370 380 390 400
KDRPVIGRYK IMSKDVKKST LPLAESSREK DLANLTFAEM NHRPSNLDMT
410 420 430 440 450
VAGASDMSML PGNQGLPLAQ GENDETIALD RLTPPLQSSV SQKASDEYVL
460 470 480 490 500
PPLEANDLDE HLIGKLPIEP NEMDQTLANM FDKKLEVFNT SDTLESKVWK
510 520 530 540 550
NGIRAEEWGE DDEAIMKNDT KHPRQAGIEG WIKATDAWTN YDVVKMNVNR
560 570 580 590 600
EARSQLDENA IDEQESYRNM VPEIGKNLFL VKSDDYMNNY PGDRPADFTV
610 620 630 640 650
NDEVSDVMKM WSGEDSTAED DVPLEQIQQE IREQVQQQDV DMEPIEEMDY
660 670 680 690 700
DAGGAAFDVD FDDRLAAPVE VEEMEGDNNR NDGRVADILF NEQMDETEVE
710 720 730 740 750
ERNEQDVQRE LEDIALAADE VAELMTSAPP PQLVGPSAEM REEIQNIGKN
760 770 780 790 800
DNAHWVPPVV GDQERQAAVT AQRKRREKKA KSRKATVEDF VHYFRDIPDD
810 820 830 840 850
EIEREITAAK CSKIADEKST FLSEQQLYLP TLGIENKPHV AFEMGLLGNS
860 870 880 890 900
GMFFKKSYGK IRLERVKNQK AEQDLFIDEA RGNKDSDCLN WLLSFSGFRC
910 920 930 940 950
MENPEPITGS DSDENLRTAV EQPFDDDFAN DYYDEDRYDP NYEQQLAAAQ
960 970 980 990 1000
MGPDMQRKLA LTASHINQMF PNIHSKRYGG EYGDSDDEFD DSFDRQSIQA
1010 1020 1030 1040 1050
KNLDAAKHKK CLAEILKTDS LSMPSIQYVL EQLTSNQTLR MNNTTIRAAD
1060 1070 1080 1090 1100
DRNETGRPAT PTMEADKTLT SVFDYRSPNK SNHDVNETMK ALTEMPDYQA
1110 1120 1130 1140 1150
ADERPNNQPT TSTYGTANTE NRKVHINGCH TLLSLALSMP SRMGETVRPS
1160 1170 1180 1190 1200
SIVSFLLHIA NENNLQIVQD RSKRSWMSDF IVLNSSESLP RGLKMGRIED
1210 1220 1230 1240 1250
QDEFWKRTQD PDAIEGTASD ANNVFSNLMR RPKAVPVRKG RGAGGQPTTS
1260
DLGAIVEEEE MEE
Length:1,263
Mass (Da):142,596
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA9951E848E66089
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43562 mRNA Translation: AAC47411.1
BX284604 Genomic DNA Translation: CAA94575.1

Protein sequence database of the Protein Information Resource

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PIRi
T19472

NCBI Reference Sequences

More...
RefSeqi
NP_502378.1, NM_069977.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C25G4.5.1; C25G4.5.1; WBGene00001085

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C25G4.5

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43562 mRNA Translation: AAC47411.1
BX284604 Genomic DNA Translation: CAA94575.1
PIRiT19472
RefSeqiNP_502378.1, NM_069977.5

3D structure databases

SMRiG5EGE9
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1271, Condensin I complex
CPX-1273, Condensin I-like dosage compensation complex
IntActiG5EGE9, 5 interactors
STRINGi6239.C25G4.5

Proteomic databases

EPDiG5EGE9
PaxDbiG5EGE9
PeptideAtlasiG5EGE9

Genome annotation databases

EnsemblMetazoaiC25G4.5.1; C25G4.5.1; WBGene00001085
GeneIDi178196
KEGGicel:CELE_C25G4.5

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178196
WormBaseiC25G4.5 ; CE08398 ; WBGene00001085 ; dpy-26

Phylogenomic databases

eggNOGiENOG502TG5K, Eukaryota
HOGENOMiCLU_007170_0_0_1
InParanoidiG5EGE9
OMAiFQKATKG
OrthoDBi257799at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EGE9

Gene expression databases

BgeeiWBGene00001085, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPY26_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EGE9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: December 14, 2011
Last modified: August 12, 2020
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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