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Protein

Hypoxia-inducible factor 1

Gene

hif-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size (PubMed:11427734, PubMed:12006646, PubMed:12686697, PubMed:15781453, PubMed:18477695, PubMed:19461873, PubMed:21093262, PubMed:19889840, PubMed:20520707, PubMed:20400959). Involved in mediating susceptibility to enteropathogenic E.coli (PubMed:16091039). Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection (PubMed:20865124, PubMed:22792069). Required for aha-1 nuclear localization (PubMed:11427734). Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression (PubMed:20400959). Role in life span extension is dependent of temperature (PubMed:21241450). Not required for survival in anoxic conditions (PubMed:11427734). Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3 (PubMed:22396654, PubMed:22194696). May be involved in manganese homeostasis by repressing divalent metal transporter smf-3 (PubMed:22194696).16 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: WormBase
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • protein dimerization activity Source: InterPro
  • RNA polymerase II transcription factor binding Source: WormBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processApoptosis, Stress response, Transcription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-5689880 Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hypoxia-inducible factor 12 Publications
Alternative name(s):
Hypoxia-induced factor 11 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hif-1Imported
ORF Names:F38A6.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F38A6.3a ; CE38182 ; WBGene00001851 ; hif-1
F38A6.3b ; CE42263 ; WBGene00001851 ; hif-1
F38A6.3c ; CE32019 ; WBGene00001851 ; hif-1
F38A6.3d ; CE38181 ; WBGene00001851 ; hif-1
F38A6.3e ; CE46300 ; WBGene00001851 ; hif-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

66% do not survive embryogenesis when cultured in hypoxic conditions of 1% oxygen. Able to survive anoxic conditions (PubMed:11427734, PubMed:12006646). Inefficient translocation of aha-1 to the nucleus (PubMed:11427734). Inability to acclimate to heat (PubMed:12686697). Partial resistance to paralysis and killing by enteropathogenic E.coli and P.aeruginosa (PubMed:16091039, PubMed:20865124). Extends lifespan in a temperature dependent manner but not when grown with a restricted diet (PubMed:19461873, PubMed:21093262). At lower temperatures impairs lifespan because of a vulval integrity defect (PubMed:21241450). Unable to survive in even relatively low concentrations of hydrogen sulfide (PubMed:19889840). Reduced body levels of Mn2+ and iron (PubMed:22194696). In low iron conditions, only 20% of animals reach the L4 larval stage (PubMed:22194696). RNAi-mediated knockdown causes an increase in ftn-1 and ftn-2 mRNA levels in normal conditions and prevents the repression of smf-3, ftn-1 and to a lesser extent ftn-2 mRNA transcription in response to low iron levels (PubMed:22194696).10 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi621P → G: Loss of egl-9-mediated hydroxylation resulting in the loss of interaction with vhl-1. Normal susceptibility to P.aeruginosa killing. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004169381 – 719Hypoxia-inducible factor 1Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6214-hydroxyproline; by egl-91 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hydroxylation on Pro-621 by egl-9 during normoxia conditions is required for vhl-1-mediated proteasomal degradation.1 Publication

Keywords - PTMi

Hydroxylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EGD2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all somatic cells.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By heat acclimation, hypoxia and addition of 50 ppm hydrogen sulfide (PubMed:11427734, PubMed:12686697, PubMed:19889840). By low iron levels (PubMed:22194696).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001851 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to aha-1 (PubMed:11427734). Interacts (hydroxylated on Pro-621) with vhl-1; the interaction induces hif-1 degradation (PubMed:11595184).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
aha-1O022193EBI-319821,EBI-2408984

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
45316, 3 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
G5EGD2

Protein interaction database and analysis system

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IntActi
G5EGD2, 52 interactors

Molecular INTeraction database

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MINTi
G5EGD2

STRING: functional protein association networks

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STRINGi
6239.F38A6.3b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
G5EGD2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EGD2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 65bHLHPROSITE-ProRule annotationAdd BLAST55
Domaini86 – 153PAS 1PROSITE-ProRule annotationAdd BLAST68
Domaini222 – 292PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini296 – 340PACSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi452 – 563Ser-richSequence analysisAdd BLAST112

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3558 Eukaryota
ENOG410YK57 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000174266

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000017809

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5EGD2

KEGG Orthology (KO)

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KOi
K08268

Identification of Orthologs from Complete Genome Data

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OMAi
EEPDLSC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CEQ

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit
cd00130 PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold

Pfam protein domain database

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Pfami
View protein in Pfam
PF00989 PAS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00091 PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55785 SSF55785, 2 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00229 sensory_box, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform a1 Publication (identifier: G5EGD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDNRKRNME RRRETSRHAA RDRRSKESDI FDDLKMCVPI VEEGTVTHLD
60 70 80 90 100
RIALLRVAAT ICRLRKTAGN VLENNLDNEI TNEVWTEDTI AECLDGFVMI
110 120 130 140 150
VDSDSSILYV TESVAMYLGL TQTDLTGRAL RDFLHPSDYD EFDKQSKMLH
160 170 180 190 200
KPRGEDTDTT GINMVLRMKT VISPRGRCLN LKSALYKSVS FLVHSKVSTG
210 220 230 240 250
GHVSFMQGIT IPAGQGTTNA NASAMTKYTE SPMGAFTTRH TCDMRITFVS
260 270 280 290 300
DKFNYILKSE LKTLMGTSFY ELVHPADMMI VSKSMKELFA KGHIRTPYYR
310 320 330 340 350
LIAANDTLAW IQTEATTITH TTKGQKGQYV ICVHYVLGIQ GAEESLVVCT
360 370 380 390 400
DSMPAGMQVD IKKEVDDTRD YIGRQPEIVE CVDFTPLIEP EDPFDTVIEP
410 420 430 440 450
VVGGEEPVKQ ADMGARKNSY DDVLQWLFRD QPSSPPPARY RSADRFRTTE
460 470 480 490 500
PSNFGSALAS PDFMDSSSRT SRPKTSYGRR AQSQGSRTTG SSSTSASATL
510 520 530 540 550
PHSANYSPLA EGISQCGLNS PPSIKSGQVV YGDARSMGRS CDPSDSSRRF
560 570 580 590 600
SALSPSDTLN VSSTRGINPV IGSNDVFSTM PFADSIAIAE RIDSSPTLTS
610 620 630 640 650
GEPILCDDLQ WEEPDLSCLA PFVDTYDMMQ MDEGLPPELQ ALYDLPDFTP
660 670 680 690 700
AVPQAPAARP VHIDRSPPAK RMHQSGPSDL DFMYTQHYQP FQQDETYWQG
710
QQQQNEQQPS SYSPFPMLS
Length:719
Mass (Da):79,934
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6F5762100E179FE
GO
Isoform b1 Publication (identifier: G5EGD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     523-523: S → SCS

Note: No experimental confirmation available.Curated
Show »
Length:721
Mass (Da):80,124
Checksum:i2FC85980E721128D
GO
Isoform c1 Publication (identifier: G5EGD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     217-226: TTNANASAMT → MSRDSEYLDR

Note: No experimental confirmation available.Curated
Show »
Length:503
Mass (Da):55,860
Checksum:i497E7B6DD02FA597
GO
Isoform d1 Publication (identifier: G5EGD2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-719: ARKNSYDDVL...SSYSPFPMLS → IYSVTDEYEQ...LPKGSIRRQH

Note: No experimental confirmation available.Curated
Show »
Length:665
Mass (Da):75,201
Checksum:i7D1D94A215878ACB
GO
Isoform e1 Publication (identifier: G5EGD2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:711
Mass (Da):78,890
Checksum:i78FEAD4A08B0D3BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3AXG6A0A0K3AXG6_CAEEL
Hypoxia-inducible factor 1
hif-1 CELE_F38A6.3, F38A6.3
713Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430051 – 216Missing in isoform c. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_0430061 – 8Missing in isoform e. 1 Publication8
Alternative sequenceiVSP_043007217 – 226TTNANASAMT → MSRDSEYLDR in isoform c. 1 Publication10
Alternative sequenceiVSP_043008415 – 719ARKNS…FPMLS → IYSVTDEYEQRVYGQISAGN DIEDCDMDSDTESIEDSGLA PEFDVDLAPIYNEKMEVDGE DEDGGEEEHVRTATMTFCNG FFATSQALRRRHATGQRTAS GQPNRRISVPLWPRRTSWIR HLVPPDRRHHTDEEHKVREV EQLDRLPRQHRPHCHTVPTT RHLQRASHNVDLTVPRVSNL DKSCTETLDLWDVAAIRPIR HDAFPPFHHQILSMCRPLEA STQSSEAMMCSPLCLLPILS PLPKGSIRRQH in isoform d. 1 PublicationAdd BLAST305
Alternative sequenceiVSP_043009523S → SCS in isoform b. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF364604 mRNA Translation: AAK62778.1
Z92833, AL023842 Genomic DNA Translation: CAB07380.2
Z92833, AL023842 Genomic DNA Translation: CAB07381.2
AL023842 Genomic DNA Translation: CAD54167.1
Z92833, AL023842 Genomic DNA Translation: CAD54141.2
Z92833, AL023842 Genomic DNA Translation: CCD31074.1

NCBI Reference Sequences

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RefSeqi
NP_001023891.2, NM_001028720.3 [G5EGD2-2]
NP_001023892.1, NM_001028721.2 [G5EGD2-3]
NP_001023893.1, NM_001028722.3 [G5EGD2-4]
NP_001023894.2, NM_001028723.2 [G5EGD2-5]
NP_508008.4, NM_075607.5 [G5EGD2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.17085

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F38A6.3a; F38A6.3a; WBGene00001851 [G5EGD2-1]
F38A6.3b; F38A6.3b; WBGene00001851 [G5EGD2-2]
F38A6.3c; F38A6.3c; WBGene00001851 [G5EGD2-3]
F38A6.3d; F38A6.3d; WBGene00001851 [G5EGD2-4]
F38A6.3e; F38A6.3e; WBGene00001851 [G5EGD2-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
180359

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F38A6.3

UCSC genome browser

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UCSCi
F38A6.3a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364604 mRNA Translation: AAK62778.1
Z92833, AL023842 Genomic DNA Translation: CAB07380.2
Z92833, AL023842 Genomic DNA Translation: CAB07381.2
AL023842 Genomic DNA Translation: CAD54167.1
Z92833, AL023842 Genomic DNA Translation: CAD54141.2
Z92833, AL023842 Genomic DNA Translation: CCD31074.1
RefSeqiNP_001023891.2, NM_001028720.3 [G5EGD2-2]
NP_001023892.1, NM_001028721.2 [G5EGD2-3]
NP_001023893.1, NM_001028722.3 [G5EGD2-4]
NP_001023894.2, NM_001028723.2 [G5EGD2-5]
NP_508008.4, NM_075607.5 [G5EGD2-1]
UniGeneiCel.17085

3D structure databases

ProteinModelPortaliG5EGD2
SMRiG5EGD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45316, 3 interactors
ELMiG5EGD2
IntActiG5EGD2, 52 interactors
MINTiG5EGD2
STRINGi6239.F38A6.3b

Proteomic databases

PaxDbiG5EGD2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF38A6.3a; F38A6.3a; WBGene00001851 [G5EGD2-1]
F38A6.3b; F38A6.3b; WBGene00001851 [G5EGD2-2]
F38A6.3c; F38A6.3c; WBGene00001851 [G5EGD2-3]
F38A6.3d; F38A6.3d; WBGene00001851 [G5EGD2-4]
F38A6.3e; F38A6.3e; WBGene00001851 [G5EGD2-5]
GeneIDi180359
KEGGicel:CELE_F38A6.3
UCSCiF38A6.3a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
180359
WormBaseiF38A6.3a ; CE38182 ; WBGene00001851 ; hif-1
F38A6.3b ; CE42263 ; WBGene00001851 ; hif-1
F38A6.3c ; CE32019 ; WBGene00001851 ; hif-1
F38A6.3d ; CE38181 ; WBGene00001851 ; hif-1
F38A6.3e ; CE46300 ; WBGene00001851 ; hif-1

Phylogenomic databases

eggNOGiKOG3558 Eukaryota
ENOG410YK57 LUCA
GeneTreeiENSGT00940000174266
HOGENOMiHOG000017809
InParanoidiG5EGD2
KOiK08268
OMAiEEPDLSC
OrthoDBiEOG091G0CEQ

Enzyme and pathway databases

ReactomeiR-CEL-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-5689880 Ub-specific processing proteases

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EGD2

Gene expression databases

BgeeiWBGene00001851 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00989 PAS, 1 hit
SMARTiView protein in SMART
SM00091 PAS, 2 hits
SUPFAMiSSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIF1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EGD2
Secondary accession number(s): G5ECE6
, G5EDZ3, G5EE28, Q8I4D0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: December 14, 2011
Last modified: December 5, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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