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UniProtKB - G5EGA6 (DHRS4_CAEEL)
Protein
Dehydrogenase/reductase SDR family member 4
Gene
dhrs-4
Organism
Caenorhabditis elegans
Status
Functioni
Catalyzes the reduction of isatin, 4-oxonon-2-enal, 9,10-phenanthrenequinone, menadione, 2,3-hexaenadione, 3,4-hexanedione and 2,3-heptanedione.
1 PublicationCatalytic activityi
- EC:1.1.1.1841 Publication
Kineticsi
- KM=0.12 mM for isatin (at 25 degrees Celsius)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 148 | SubstrateBy similarity | 1 | |
Active sitei | 161 | Proton acceptorBy similarity | 1 | |
Binding sitei | 165 | NADPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 14 – 38 | NADPBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- carbonyl reductase (NADPH) activity Source: UniProtKB
- catalytic activity Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Enzyme and pathway databases
Reactomei | R-CEL-5365859, RA biosynthesis pathway R-CEL-9033241, Peroxisomal protein import |
SABIO-RKi | G5EGA6 |
Names & Taxonomyi
Protein namesi | Recommended name: Dehydrogenase/reductase SDR family member 4By similarity (EC:1.1.1.1841 Publication) |
Gene namesi | Name:dhrs-4Imported ORF Names:F54F3.4Imported |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F54F3.4 ; CE19894 ; WBGene00010063 ; dhrs-4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000431306 | 1 – 260 | Dehydrogenase/reductase SDR family member 4CuratedAdd BLAST | 260 |
Proteomic databases
EPDi | G5EGA6 |
PaxDbi | G5EGA6 |
PeptideAtlasi | G5EGA6 |
PRIDEi | G5EGA6 |
Expressioni
Gene expression databases
Bgeei | WBGene00010063, Expressed in material anatomical entity and 4 other tissues |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | G5EGA6 |
SMRi | G5EGA6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG0725, Eukaryota |
HOGENOMi | CLU_010194_1_1_1 |
InParanoidi | G5EGA6 |
OMAi | VGTLGKQ |
OrthoDBi | 1194344at2759 |
PhylomeDBi | G5EGA6 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
G5EGA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSNCRRFEG KVAIVTAATK GIGLAIAERL LDEGASVVIG SRNQKNVDEA
60 70 80 90 100
IEYLKNKGLT KVAGIAGHIA STDDQKKLVD FTLQKFGKIN ILVNNHGINP
110 120 130 140 150
AFGHILEVSD QVWDKLFEVN VKAGFQMTKL VHPHIAKEGG GAIIFNASYS
160 170 180 190 200
AYKSPPGIAA YGVTKTTLVG LTRALAMGLA KDNIRVNGIA PGVIKTKMSQ
210 220 230 240 250
VLWDGGEDAE KELTDIQEIA LGRLGVPDDC AGTVAYLASD DSSYITGEMI
260
IIAGGVQARL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z79696, Z81592 Genomic DNA Translation: CAB01974.1 |
PIRi | T22676 |
RefSeqi | NP_506230.1, NM_073829.5 |
Genome annotation databases
EnsemblMetazoai | F54F3.4.1; F54F3.4.1; WBGene00010063 |
GeneIDi | 179772 |
KEGGi | cel:CELE_F54F3.4 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z79696, Z81592 Genomic DNA Translation: CAB01974.1 |
PIRi | T22676 |
RefSeqi | NP_506230.1, NM_073829.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5OJG | X-ray | 1.90 | A/B | 1-260 | [»] | |
5OJI | X-ray | 1.60 | A/B | 1-260 | [»] | |
AlphaFoldDBi | G5EGA6 | |||||
SMRi | G5EGA6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 44791, 5 interactors |
STRINGi | 6239.F54F3.4 |
Proteomic databases
EPDi | G5EGA6 |
PaxDbi | G5EGA6 |
PeptideAtlasi | G5EGA6 |
PRIDEi | G5EGA6 |
Genome annotation databases
EnsemblMetazoai | F54F3.4.1; F54F3.4.1; WBGene00010063 |
GeneIDi | 179772 |
KEGGi | cel:CELE_F54F3.4 |
Organism-specific databases
CTDi | 179772 |
WormBasei | F54F3.4 ; CE19894 ; WBGene00010063 ; dhrs-4 |
Phylogenomic databases
eggNOGi | KOG0725, Eukaryota |
HOGENOMi | CLU_010194_1_1_1 |
InParanoidi | G5EGA6 |
OMAi | VGTLGKQ |
OrthoDBi | 1194344at2759 |
PhylomeDBi | G5EGA6 |
Enzyme and pathway databases
Reactomei | R-CEL-5365859, RA biosynthesis pathway R-CEL-9033241, Peroxisomal protein import |
SABIO-RKi | G5EGA6 |
Miscellaneous databases
PROi | PR:G5EGA6 |
Gene expression databases
Bgeei | WBGene00010063, Expressed in material anatomical entity and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHRS4_CAEEL | |
Accessioni | G5EGA6Primary (citable) accession number: G5EGA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 26, 2014 |
Last sequence update: | December 14, 2011 | |
Last modified: | May 25, 2022 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families