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Entry version 46 (11 Dec 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Cactin

Gene

cacn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: WormBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cactin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cacn-1
ORF Names:W03H9.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
W03H9.4a ; CE46363 ; WBGene00012230 ; cacn-1
W03H9.4b ; CE46257 ; WBGene00012230 ; cacn-1
W03H9.4c ; CE45519 ; WBGene00012230 ; cacn-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004192671 – 657CactinAdd BLAST657

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EG14

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EG14

PeptideAtlas

More...
PeptideAtlasi
G5EG14

PRoteomics IDEntifications database

More...
PRIDEi
G5EG14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pharynx, intestine, vulva and spermatheca (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in migrating distal tip cells throughout larval development (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00012230 Expressed in 6 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
40348, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.W03H9.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EG14

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili23 – 77Sequence analysisAdd BLAST55
Coiled coili352 – 403Sequence analysisAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CACTIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2370 Eukaryota
ENOG410XPKF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183102

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EG14

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLIRFMA

Database of Orthologous Groups

More...
OrthoDBi
1252926at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019134 Cactin_C
IPR018816 Cactin_central

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10312 Cactin_mid, 1 hit
PF09732 CactinC_cactus, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: G5EG14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKDSKKHKK ERRRERSPST SDSDEERLQK RLAEQRSLKK DEKRRQKEEM
60 70 80 90 100
KKNESAEEKR ARRMEKKMRK DAKRKDADAE DTLIPPELNY TNLNNPFNDT
110 120 130 140 150
KLTQTFVWGK KLEREGKSGL TQDEITKQTS QRIRKNLHEA AEFKRIRDSR
160 170 180 190 200
AAAKEDMEMM KRDADLRAGQ ISDTKEREFQ MDQIKERTRI RIDQGRAKAI
210 220 230 240 250
DLLSRYARFA DENPHTAKIP DFELENPMEY LKASCKSVDD YEDLIEDIKT
260 270 280 290 300
YREVDGWAKN ETWWMDVTRI AEDEIQKKAA QNRGDVHASV QTEVQNMFKN
310 320 330 340 350
KSIDELLKLE DQMDAKIRGN SGNKGYWQDL DDQLKVFIAR KRLREHHGRV
360 370 380 390 400
LRLQLAIIKE EQKKEIQQQE SEELLPVAEV PPQVKIQKEE EEEEEEDEDD
410 420 430 440 450
EKISKKVRRK IDVQTLDDPE LDEPERERKW RALTGDQLDD VTRELYRIGC
460 470 480 490 500
YSPTYISADD TMPGIEILDE QADVDNLTER RNRNRGTLPS SSAASSGAPQ
510 520 530 540 550
GASSKMMAIA REGMEADESI FGAEEQLAAQ RHLWSDKYRP RKPTYLNRVQ
560 570 580 590 600
TGFDWNKYNQ THYDQDNPPP KIVQGYKFNI FYPDLLDMTV APRFGLTSCE
610 620 630 640 650
DPDFAIIRFK AGPPYEDIAF KVVNREWETL HKNGYKCQFQ NGVFQLWFMF

KKYRYRR
Length:657
Mass (Da):77,418
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD86210EC02C767E2
GO
Isoform b (identifier: G5EG14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:345
Mass (Da):40,449
Checksum:i1845FA431495EC9A
GO
Isoform c (identifier: G5EG14-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-461: Missing.

Show »
Length:196
Mass (Da):22,807
Checksum:i7526F77A5EC98D2E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0441431 – 461Missing in isoform c. CuratedAdd BLAST461
Alternative sequenceiVSP_0441441 – 312Missing in isoform b. CuratedAdd BLAST312

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z82067, Z83234 Genomic DNA Translation: CAB76738.2
Z83234 Genomic DNA Translation: CBY25190.2
Z83234 Genomic DNA Translation: CBY25191.1

NCBI Reference Sequences

More...
RefSeqi
NP_001254420.1, NM_001267491.1 [G5EG14-2]
NP_001254421.1, NM_001267492.1 [G5EG14-3]
NP_001254422.1, NM_001267493.1 [G5EG14-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W03H9.4a.1; W03H9.4a.1; WBGene00012230 [G5EG14-1]
W03H9.4a.2; W03H9.4a.2; WBGene00012230 [G5EG14-1]
W03H9.4b.1; W03H9.4b.1; WBGene00012230 [G5EG14-2]
W03H9.4c.1; W03H9.4c.1; WBGene00012230 [G5EG14-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W03H9.4

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82067, Z83234 Genomic DNA Translation: CAB76738.2
Z83234 Genomic DNA Translation: CBY25190.2
Z83234 Genomic DNA Translation: CBY25191.1
RefSeqiNP_001254420.1, NM_001267491.1 [G5EG14-2]
NP_001254421.1, NM_001267492.1 [G5EG14-3]
NP_001254422.1, NM_001267493.1 [G5EG14-1]

3D structure databases

SMRiG5EG14
ModBaseiSearch...

Protein-protein interaction databases

BioGridi40348, 1 interactor
STRINGi6239.W03H9.4a

Proteomic databases

EPDiG5EG14
PaxDbiG5EG14
PeptideAtlasiG5EG14
PRIDEiG5EG14

Genome annotation databases

EnsemblMetazoaiW03H9.4a.1; W03H9.4a.1; WBGene00012230 [G5EG14-1]
W03H9.4a.2; W03H9.4a.2; WBGene00012230 [G5EG14-1]
W03H9.4b.1; W03H9.4b.1; WBGene00012230 [G5EG14-2]
W03H9.4c.1; W03H9.4c.1; WBGene00012230 [G5EG14-3]
GeneIDi175066
KEGGicel:CELE_W03H9.4

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175066
WormBaseiW03H9.4a ; CE46363 ; WBGene00012230 ; cacn-1
W03H9.4b ; CE46257 ; WBGene00012230 ; cacn-1
W03H9.4c ; CE45519 ; WBGene00012230 ; cacn-1

Phylogenomic databases

eggNOGiKOG2370 Eukaryota
ENOG410XPKF LUCA
GeneTreeiENSGT00950000183102
InParanoidiG5EG14
OMAiCLIRFMA
OrthoDBi1252926at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EG14

Gene expression databases

BgeeiWBGene00012230 Expressed in 6 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR019134 Cactin_C
IPR018816 Cactin_central
PfamiView protein in Pfam
PF10312 Cactin_mid, 1 hit
PF09732 CactinC_cactus, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATIN_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EG14
Secondary accession number(s): E5QCI6, E5QCI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: December 14, 2011
Last modified: December 11, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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