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Entry version 75 (02 Jun 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Cyclin-dependent kinase 7

Gene

cdk-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei34ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei130Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi11 – 19ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-112382, Formation of RNA Pol II elongation complex
R-CEL-113418, Formation of the Early Elongation Complex
R-CEL-5696395, Formation of Incision Complex in GG-NER
R-CEL-674695, RNA Polymerase II Pre-transcription Events
R-CEL-6781823, Formation of TC-NER Pre-Incision Complex
R-CEL-6782135, Dual incision in TC-NER
R-CEL-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-CEL-6807505, RNA polymerase II transcribes snRNA genes
R-CEL-69202, Cyclin E associated events during G1/S transition
R-CEL-69231, Cyclin D associated events in G1
R-CEL-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69656, Cyclin A:Cdk2-associated events at S phase entry
R-CEL-72086, mRNA Capping
R-CEL-73772, RNA Polymerase I Promoter Escape
R-CEL-73776, RNA Polymerase II Promoter Escape
R-CEL-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-CEL-75953, RNA Polymerase II Transcription Initiation
R-CEL-75955, RNA Polymerase II Transcription Elongation
R-CEL-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-CEL-77075, RNA Pol II CTD phosphorylation and interaction with CE

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
G5EFV5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase 7Curated (EC:2.7.11.22By similarity, EC:2.7.11.231 Publication)
Alternative name(s):
Cell division protein kinase 7Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdk-7Imported
ORF Names:Y39G10AL.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y39G10AL.3 ; CE30320 ; WBGene00000408 ; cdk-7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in an arrest at approximately 50-cell embryonic stage. The phenotype is more severe when done in a cdk7(ax224) mutant background where the embryonic arrest occurs at the 1-cell stage due to an arrest in early meiosis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi280C → T in ax224; temperature-sensitive embryonic arrest at approximately 50-cell stage characterized by a severe defect in the transcription of several mRNAs and a severe decrease in ama-1 phosphorylation. Increase in cell cycle length at the interphase and M phase stages. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004326211 – 330Cyclin-dependent kinase 7Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei163PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EFV5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EFV5

PeptideAtlas

More...
PeptideAtlasi
G5EFV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000408, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Catalytic component which, in association with cyclin H (cyh-1) and mat1, is likely to form the CAK complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.Y39G10AL.3.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EFV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST285

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni305 – 330DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0659, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155179

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_181_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EFV5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WHSEPKP

Database of Orthologous Groups

More...
OrthoDBi
1367115at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EFV5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07841, STKc_CDK7, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037770, CDK7
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR24056:SF375, PTHR24056:SF375, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EFV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRYDTIKH LGEGQFANVY LAQDLESGEC VAIKKIKLGS REEAKDGINR
60 70 80 90 100
TAIREIKLLK EIHHDNIIGL RDVIGHRTSI QLVFDFMDTD LEHVIKDKEI
110 120 130 140 150
ILMPAHIKNI TMQMLLGLEF LHVHWILHRD LKPNNLLMNK MGRVKLTDFG
160 170 180 190 200
LARFFGSPNR NYTHQVVTRW YRAPELLFGA RSYGVGIDIW SVGCIIAELL
210 220 230 240 250
LRNPIFPGES DIDQLVKIFN ILGCPTPETW PNMTEMNSYV IIKPQTEYMA
260 270 280 290 300
LNYYFSAAPQ DLLDLMAGMW TFDPIKRLTC TQSLQMEYFR TQPFCCLDEE
310 320 330
LPLPKKQQPQ KRSRRLDDDG TRPVRRLNFD
Length:330
Mass (Da):38,353
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD036FF760565287B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF154004 mRNA Translation: AAD38186.1
FO081124 Genomic DNA Translation: CCD69307.1

NCBI Reference Sequences

More...
RefSeqi
NP_490952.2, NM_058551.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y39G10AL.3.1; Y39G10AL.3.1; WBGene00000408
Y39G10AL.3.2; Y39G10AL.3.2; WBGene00000408
Y39G10AL.3.3; Y39G10AL.3.3; WBGene00000408

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
171784

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154004 mRNA Translation: AAD38186.1
FO081124 Genomic DNA Translation: CCD69307.1
RefSeqiNP_490952.2, NM_058551.6

3D structure databases

SMRiG5EFV5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.Y39G10AL.3.1

Proteomic databases

EPDiG5EFV5
PaxDbiG5EFV5
PeptideAtlasiG5EFV5

Genome annotation databases

EnsemblMetazoaiY39G10AL.3.1; Y39G10AL.3.1; WBGene00000408
Y39G10AL.3.2; Y39G10AL.3.2; WBGene00000408
Y39G10AL.3.3; Y39G10AL.3.3; WBGene00000408
GeneIDi171784

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
171784
WormBaseiY39G10AL.3 ; CE30320 ; WBGene00000408 ; cdk-7

Phylogenomic databases

eggNOGiKOG0659, Eukaryota
GeneTreeiENSGT00940000155179
HOGENOMiCLU_000288_181_1_1
InParanoidiG5EFV5
OMAiWHSEPKP
OrthoDBi1367115at2759
PhylomeDBiG5EFV5

Enzyme and pathway databases

ReactomeiR-CEL-112382, Formation of RNA Pol II elongation complex
R-CEL-113418, Formation of the Early Elongation Complex
R-CEL-5696395, Formation of Incision Complex in GG-NER
R-CEL-674695, RNA Polymerase II Pre-transcription Events
R-CEL-6781823, Formation of TC-NER Pre-Incision Complex
R-CEL-6782135, Dual incision in TC-NER
R-CEL-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-CEL-6807505, RNA polymerase II transcribes snRNA genes
R-CEL-69202, Cyclin E associated events during G1/S transition
R-CEL-69231, Cyclin D associated events in G1
R-CEL-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69656, Cyclin A:Cdk2-associated events at S phase entry
R-CEL-72086, mRNA Capping
R-CEL-73772, RNA Polymerase I Promoter Escape
R-CEL-73776, RNA Polymerase II Promoter Escape
R-CEL-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-CEL-75953, RNA Polymerase II Transcription Initiation
R-CEL-75955, RNA Polymerase II Transcription Elongation
R-CEL-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-CEL-77075, RNA Pol II CTD phosphorylation and interaction with CE
SignaLinkiG5EFV5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EFV5

Gene expression databases

BgeeiWBGene00000408, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

CDDicd07841, STKc_CDK7, 1 hit
InterProiView protein in InterPro
IPR037770, CDK7
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR24056:SF375, PTHR24056:SF375, 1 hit
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDK7_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EFV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: December 14, 2011
Last modified: June 2, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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