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Entry version 87 (13 Nov 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Unc-40 protein

Gene

unc-40

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-373752 Netrin-1 signaling
R-CEL-376176 Signaling by ROBO receptors
R-CEL-418885 DCC mediated attractive signaling
R-CEL-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-CEL-525793 Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Unc-40 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-40Imported
ORF Names:CELE_T19B4.7Imported, T19B4.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
T19B4.7 ; CE25115 ; WBGene00006776 ; unc-40

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1083 – 1107HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509197123 – 1415Sequence analysisAdd BLAST1393

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006776 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5EF96, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.T19B4.7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 130Ig-likeInterPro annotationAdd BLAST90
Domaini148 – 235Ig-likeInterPro annotationAdd BLAST88
Domaini244 – 331Ig-likeInterPro annotationAdd BLAST88
Domaini336 – 421Ig-likeInterPro annotationAdd BLAST86
Domaini442 – 532Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini538 – 630Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini635 – 730Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini739 – 830Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini851 – 944Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini947 – 1046Fibronectin type-IIIInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni612 – 658DisorderedSequence analysisAdd BLAST47
Regioni830 – 853DisorderedSequence analysisAdd BLAST24
Regioni940 – 970DisorderedSequence analysisAdd BLAST31
Regioni1112 – 1136DisorderedSequence analysisAdd BLAST25
Regioni1178 – 1274DisorderedSequence analysisAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1383 – 1406Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi612 – 650PolarSequence analysisAdd BLAST39
Compositional biasi1184 – 1218PolarSequence analysisAdd BLAST35
Compositional biasi1228 – 1243PolarSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4221 Eukaryota
ENOG410Z913 LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
RERMINS

Database of Orthologous Groups

More...
OrthoDBi
217780at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EF96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILRHFGFIL IILTVYLSST HATTRKHHRR SIDNDARNLG FQFVMEPRRN
60 70 80 90 100
VTVMESSSHL LECSYVLAHE RLVHDVRIEW KRDGVLLSER TSSRIKVMSN
110 120 130 140 150
GSLWIESVSS AEEGTYQCAV HVTTKSDQTS DTWTFLSRKA TLRLADLAKF
160 170 180 190 200
ELQAIDRTLA KGQPTAFHCL INSKPTPTAV WLHNDEPIVN GGEYHILPVS
210 220 230 240 250
NTLEISSTQS RHEGTYRCTV EGAGKRRSSQ TARLTVTTET VSNELVFITT
260 270 280 290 300
PRLQVVEQGD EFLLECLVAS LIRPQVRWLK DSRQIIVDGV RIRRVGVSSI
310 320 330 340 350
LVSRASIEDT GLYTCRASNN DDSIDRAVSV EVRAPPRITT RPTTKVAVET
360 370 380 390 400
ADVELECGTA AARPEARVNW YKNGEAIIGS EYFVIEPNRL RILGVVRADQ
410 420 430 440 450
AIYQCIAEND VGSEQASAQL LVDAPDSSSV AASSGVPMTS SAPLGLRSTS
460 470 480 490 500
SGSRFINVEW DPPVQRNGNI MRYHIFYKDN LIDRERMINS SSTSATLTSL
510 520 530 540 550
QPSTMYLIRV TAENEAGMGK FSDSLKVTTN KEQAVPGKVA SLTTTATGPE
560 570 580 590 600
TIDIRWSPPS GGQPALRYKI FYSHDPLEKN EKETLITTST THYTLHGMDK
610 620 630 640 650
YTGYQIRIEA EGSNGSGLSS DTVKVRTQSD EPSAPPVNIQ AEADSSTSVR
660 670 680 690 700
VSWDEPEEES VNGEITGYRL KYKTKARGAK GNTLVIDATA REYTMGNLEP
710 720 730 740 750
NTQYLIRMAV VNHNGTGPFS DWVSIDTPGQ DKEERTLGAP REIRPHAGID
760 770 780 790 800
YILVSWLPPA DEQNLVRGYQ IGWGLSVPDT ETIRVTASTT QYKIARLHSE
810 820 830 840 850
RDYVISLRAF NNLGSGFPIY ETVRTLSRET PSHFNEDSDS DDSDVGSSES
860 870 880 890 900
TPVGVRAEAI SATSIRVMWT ESDETAFNTQ YTVRYSTAVD GNQHRYVNST
910 920 930 940 950
ETWATVEGLR PATEYEFAVR AVASNGQLST WSMATRNRTL AAPPSSAPRD
960 970 980 990 1000
LTVLPAESGD PHSSSLHWQP PKYSNGEIEE YLVFYTDRAS LADKDWTINY
1010 1020 1030 1040 1050
VAGDKLSHQV SNLLPKANYF FKIQARNEKG HGPFSSVVGY TPSGGAILSG
1060 1070 1080 1090 1100
KDRHNARGHG SAASGDTVSL VDQLQSLLHS NPLYLILLAA FALILILTLI
1110 1120 1130 1140 1150
LIIMCCWKRS SGGGRKNGYQ SGKKTSAGAG SGGGIGGLGG PPNDLWINGT
1160 1170 1180 1190 1200
GSHMRAGASD YMVDGLATAH LTAADIESPT PRYHHLQGQG TLTRSYHQSS
1210 1220 1230 1240 1250
QSLEGRQRTP QVVYTGTGRH QPIQRIDFES PYGSSSAIGS ASTPPLPMQA
1260 1270 1280 1290 1300
PPSGPPTVID GYRTLRGTPP NSSAANALRS FTQLAGATPP PPHSAASSSS
1310 1320 1330 1340 1350
RPTIIAAGGR QVPVGRATAQ PRVNVANIYS PFASCSASSD AGESDKKSGE
1360 1370 1380 1390 1400
CMEMRETTPI KSNTAGSSNG EKMNTNMNPS HSAEDLNAHL ENLDTMLDDL
1410
QQLQHNLHFE TSMDK
Length:1,415
Mass (Da):154,437
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2D90F76F9FEB6A9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70618 mRNA Translation: AAB17088.1
BX284601 Genomic DNA Translation: CCD62978.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T25892

NCBI Reference Sequences

More...
RefSeqi
NP_491664.1, NM_059263.7

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T19B4.7.1; T19B4.7.1; WBGene00006776

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T19B4.7

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70618 mRNA Translation: AAB17088.1
BX284601 Genomic DNA Translation: CCD62978.1
PIRiT25892
RefSeqiNP_491664.1, NM_059263.7

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5EF96, 1 interactor
STRINGi6239.T19B4.7

Genome annotation databases

EnsemblMetazoaiT19B4.7.1; T19B4.7.1; WBGene00006776
GeneIDi172233
KEGGicel:CELE_T19B4.7

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172233
WormBaseiT19B4.7 ; CE25115 ; WBGene00006776 ; unc-40

Phylogenomic databases

eggNOGiKOG4221 Eukaryota
ENOG410Z913 LUCA
OMAiRERMINS
OrthoDBi217780at2759

Enzyme and pathway databases

ReactomeiR-CEL-373752 Netrin-1 signaling
R-CEL-376176 Signaling by ROBO receptors
R-CEL-418885 DCC mediated attractive signaling
R-CEL-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-CEL-525793 Myogenesis

Gene expression databases

BgeeiWBGene00006776 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EF96_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EF96
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 13, 2019
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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