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Entry version 54 (08 May 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

C34F6.10

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1442490 Collagen degradation
R-CEL-1474244 Extracellular matrix organization
R-CEL-1650814 Collagen biosynthesis and modifying enzymes
R-CEL-186797 Signaling by PDGF
R-CEL-2022090 Assembly of collagen fibrils and other multimeric structures
R-CEL-204005 COPII-mediated vesicle transport
R-CEL-216083 Integrin cell surface interactions
R-CEL-2214320 Anchoring fibril formation
R-CEL-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-CEL-419037 NCAM1 interactions
R-CEL-5694530 Cargo concentration in the ER
R-CEL-8948216 Collagen chain trimerization
R-CEL-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:C34F6.10Imported, CELE_C34F6.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
C34F6.10 ; CE43927 ; WBGene00007944

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1414 – 1434HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EF49

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EF49

PeptideAtlas

More...
PeptideAtlasi
G5EF49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007944 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C34F6.10

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
G5EF49

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini610 – 700Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini705 – 791Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini910 – 1008Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini1009 – 1098Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1102 – 1197Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1198 – 1289Fibronectin type-IIIInterPro annotationAdd BLAST92

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE8R Eukaryota
ENOG410XNUW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167764

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EF49

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHGQNGY

Database of Orthologous Groups

More...
OrthoDBi
633003at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EF49

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EF49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDELSNPA AAANEGIRQE FFRNFLKATG TSGGDMKTLE TLDDGGSTSS
60 70 80 90 100
HQTSPEYPSP PPPSNSPPES MASLQAESPI EDEDARHEMT STEGTSSTGT
110 120 130 140 150
GSPQEPKTWI SQPGYHPVPI SGPLPRHPQS ILFVHVNDGE ILQLHQQGNN
160 170 180 190 200
EVVGNLLGPG TVRMIGEPGM TNQPLPIQLR HNQQCHQFVD EEGNLRHVVL
210 220 230 240 250
SVASSDNSGQ SSQELNVPQL VGSQQLLNAI GGTPTQNGPG TSSSRGSGRG
260 270 280 290 300
NHGGGRRNYG NQRSLHTNNN ESGQHSQNGH SGHRNVYSRG NYRGNKYNSR
310 320 330 340 350
GRMDYHGKAR NDNPSYMANN VQELPELAVN THGSIDSNVQ VTASTTQDMV
360 370 380 390 400
TLRQPTPVMT LPPPPQQRSL LGEPSGPPMG EMQPIVHGIP SAQSVNFPPP
410 420 430 440 450
GLPLLIPSVH EIPRQDLSVM PAMMNGSVQS TMMQDPMMPG TSMGMNPQMF
460 470 480 490 500
GVPPPPPGMM ILSTDAAFNN NKWIPYQTLG ENERLLKVLS TLRPIRVANT
510 520 530 540 550
LTTEMEFLYT PLKINDYRFE HGICLFGPIE NSDVSYHATV FDLSGIMITT
560 570 580 590 600
VILEVNKSGD DIVSNLFRVQ SLHPNTTYKI NMKAVIIDRG LHGQQTDDLC
610 620 630 640 650
FRTAPGRPEP PTEVEILSRG LHFIELVWKT AINNGAFISH YHVYIHENEL
660 670 680 690 700
EDGRMMQTAE EKIQISNLIP QTCYKIRIHS INALGESMEG YELDVWTKPN
710 720 730 740 750
SPPLAPENIS VFAQSHRSIR VSWDKNPNCT IWIEVYNCAS GKGGYARENF
760 770 780 790 800
GGDQTVIGEL DPDTEYQMRV IARNEFGEGH SEYINMRTQK YRKSEHPSRF
810 820 830 840 850
RQYSDDHRKV NYDRSPSTPF FVRFVDNCPE MAWKNFASPQ DEISFLVEGS
860 870 880 890 900
TFEMPEKYIQ LYRGNSSSLI VLDSKMHYIR VINIFKKGQR SPPSERAVIP
910 920 930 940 950
REYFKYRPEK ITDVKISLRS ENCVLVKWQT LDIKSNKLPE TSKIIYYVQR
960 970 980 990 1000
CDLTENQVLC AGEEDHCFFD NIPGETTISV QVRAAVSFHD ALTHGDWSVL
1010 1020 1030 1040 1050
SHFTTPRGLP SPVINAKFNV KCSTLYWDCL DKSTDLQYTV HIRQLPTKRD
1060 1070 1080 1090 1100
LLKVTTKAKN IVLDSVQPGE KYSVTLISLT TVGKSKQRTE LEINVPALKP
1110 1120 1130 1140 1150
SAPEDVAVSQ VQIDRCTVSW TAAEGNGSPI IGYVVRMMLN GELFSEHFVT
1160 1170 1180 1190 1200
ESENETNYRH VLKYLDPNTE YLINIAAKNS VGFSEKIEAV VKTVPLCPTI
1210 1220 1230 1240 1250
PKIWCDCEAT ALKIHWDRVT SGNSMMYKLM KINKNAQQVT LYEGENNTAK
1260 1270 1280 1290 1300
VKSLKENTKY VFKLRVSDRA TGASTWSESF SFSTTTAPPP PLKKSPSTAL
1310 1320 1330 1340 1350
VSGHSYLYRI EWENCLPDSS QHYYRLQIAD ATVKGAKWQL CYEGRNHFYE
1360 1370 1380 1390 1400
LNTETYPGAL HVRVMCVRKH LEEELKGSPS PVGYIGNVPP TIESVKNEEI
1410 1420 1430 1440 1450
HQKSRLHLFT TDRAYAYSLL VLLIFLFLMI LSFSEKAFEY ITGMPIEKLS
1460
SGNAATSPPS SKPPQ
Length:1,465
Mass (Da):163,685
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADC9F8BB9A77B358
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAB03937.3

NCBI Reference Sequences

More...
RefSeqi
NP_509877.3, NM_077476.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C34F6.10; C34F6.10; WBGene00007944

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C34F6.10

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAB03937.3
RefSeqiNP_509877.3, NM_077476.5

3D structure databases

SMRiG5EF49
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C34F6.10

Proteomic databases

EPDiG5EF49
PaxDbiG5EF49
PeptideAtlasiG5EF49

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC34F6.10; C34F6.10; WBGene00007944
GeneIDi181313
KEGGicel:CELE_C34F6.10

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181313
WormBaseiC34F6.10 ; CE43927 ; WBGene00007944

Phylogenomic databases

eggNOGiENOG410IE8R Eukaryota
ENOG410XNUW LUCA
GeneTreeiENSGT00940000167764
InParanoidiG5EF49
OMAiGHGQNGY
OrthoDBi633003at2759
PhylomeDBiG5EF49

Enzyme and pathway databases

ReactomeiR-CEL-1442490 Collagen degradation
R-CEL-1474244 Extracellular matrix organization
R-CEL-1650814 Collagen biosynthesis and modifying enzymes
R-CEL-186797 Signaling by PDGF
R-CEL-2022090 Assembly of collagen fibrils and other multimeric structures
R-CEL-204005 COPII-mediated vesicle transport
R-CEL-216083 Integrin cell surface interactions
R-CEL-2214320 Anchoring fibril formation
R-CEL-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-CEL-419037 NCAM1 interactions
R-CEL-5694530 Cargo concentration in the ER
R-CEL-8948216 Collagen chain trimerization
R-CEL-8957275 Post-translational protein phosphorylation

Gene expression databases

BgeeiWBGene00007944 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EF49_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EF49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 8, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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