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Entry version 73 (08 May 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Exchange factor for Arf-6

Gene

efa-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes (PubMed:21943602, PubMed:26339988). Limits microtubule growth near the cellular cortex of early embryonic cells (PubMed:21076413).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exchange factor for Arf-61 Publication
Alternative name(s):
Arf guanine nucleotide exchange factor efa-61 Publication
Pleckstrin homology domain-containing protein efa-61 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:efa-61 PublicationImported
ORF Names:Y55D9A.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
Y55D9A.1a ; CE19234 ; WBGene00013223 ; efa-6
Y55D9A.1b ; CE29066 ; WBGene00013223 ; efa-6
Y55D9A.1c ; CE40826 ; WBGene00013223 ; efa-6
Y55D9A.1d ; CE44770 ; WBGene00013223 ; efa-6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abnormally long and dense microtubules at the cellular cortex of early embryonic cells and growing microtubule plus ends reside at the cortex for up to five times longer. Causes excess centrosome separation and displacement towards the cellular cortex early in mitosis and subsequently a loss of anaphase spindle-pole oscillations and increased rates of spindle elongation. The centrosome separation phenotype is dependent on the motor protein dynein. Weakly delayed nuclear envelope breakdown (PubMed:21076413). Displays mild posterior lateral microtubule (PLM) axon overshooting in development and enhanced PLM regrowth following neuronal injury acting early in regrowth (PubMed:21943602). Axons display elevated numbers of growing microtubules in the steady (uninjured) state and display impenetrant developmental overgrowth in the absence of injury (PubMed:26339988).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi449E → K: Localizes to the cellular cortex of embryo and promotes robust spindle rocking as in wild-type during the first embryonic mitosis. Inhibits axon regrowth following neuronal injury. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004375021 – 818Exchange factor for Arf-6Add BLAST818

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EET6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform b: Enriched cortically both in the anterior portion of the one-cell zygote and at the blastomere boundary in two-cell embryos. Isoform c: Localizes to nonpolarized cellular cortex in oocytes and early one-cell zygotes and anterior cellular cortex in one-cell embryos subsequent to pseudocleavage. Present at the interface of the AB and P1 cells. Undetectable by the four-cell stage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00013223 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via short N-terminal region) with microtubule-associated proteins tac-1 and zyg-8.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.Y55D9A.1b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EET6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini356 – 532SEC7PROSITE-ProRule annotationAdd BLAST177
Domaini569 – 681PHPROSITE-ProRule annotationAdd BLAST113

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A short conserved N-terminal region is necessary for the function of this protein (PubMed:21943602, PubMed:26339988). Transient relocalization to microtubule minus ends after neuronal injury also requires this region (PubMed:26339988).2 Publications

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0932 Eukaryota
COG5307 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000254799

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EET6

KEGG Orthology (KO)

More...
KOi
K12494

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWCEKIN

Database of Orthologous Groups

More...
OrthoDBi
532213at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EET6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15410 PH_9, 1 hit
PF01369 Sec7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00683 SPECTRINPH

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform b2 Publications (identifier: G5EET6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKVASSGAE EALATIDGAP RRNVKKSEAF VMSGDVLISL NRNVSSTYAK
60 70 80 90 100
LLGDQLPPGT TVASSIHPHQ LSRATASAGV SFPSMNRNGA AAQKLSRLPV
110 120 130 140 150
PVSTSQIERR GSLARKTSEE SSPTAIRMLK TAPIERMEST DVEESEEETV
160 170 180 190 200
MMTTDEKENQ KKPNENDDEV MVVDEEQFIV VSNDMKSPNE EIVAKSLRSA
210 220 230 240 250
MFTMPTDNHH HSYNSSPQIS TLSPHLRSNG DGPSRSPVYD DVDDDLNGSL
260 270 280 290 300
DAKDMSNNSH QQSFRSPENY SEKDTPSKHS VVTIDGSGVS NHYDQDGMFS
310 320 330 340 350
HVYYSTQDTT PKHGSPSLRK QIFESRTTPN TAASNSSASA SPSLHATSES
360 370 380 390 400
RGATGGVSLR SAESSNLNQT AVPSTSTNSV GGEREAAQIA RNLYELKNCT
410 420 430 440 450
STQVADRLNE QNEFSFLILV KYLELFQFST TRIDAALREF LSRVELRGES
460 470 480 490 500
SARERLLRVF SARYLECNPA IFDSLDEVHT LTCALLLLNS DLHGPNMGKK
510 520 530 540 550
MTARDFITNI AHTGCTFKRE MLKTLFQSIK DNAISLQNSA KNSTANGSVA
560 570 580 590 600
STSRRQPQQI YEVDPDSVVE YYSGFLMRKY VRETDGGKTP FGRRSWRMVY
610 620 630 640 650
ARLRGLVLYF DTDEHPKATS RYASLENAVS LHHALAEPAP DYKKKSFVFR
660 670 680 690 700
VRIAHGGEIL FQTSNQKELQ EWCEKINFVA AAFSSPTLPL PVTSKPETAP
710 720 730 740 750
MPRLPRIPCL APITKQLSTH EARVAELNEM IEIVSQSVSP NQPQQLITDR
760 770 780 790 800
WVLLSFEKRR YSTYINVLRR SLEARKASSA TTMNIMMTPT RRQQQNQKPV
810
VSEDRLSYTD AVNGAAAH
Length:818
Mass (Da):90,646
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E0B4E87563262C0
GO
Isoform a1 Publication (identifier: G5EET6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-100: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:816
Mass (Da):90,450
Checksum:i0049910DC458F2E6
GO
Isoform c2 Publications (identifier: G5EET6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-100: Missing.
     180-230: Missing.

Show »
Length:765
Mass (Da):84,817
Checksum:i1A23662010F5AFAD
GO
Isoform d1 Publication (identifier: G5EET6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:634
Mass (Da):70,786
Checksum:i97F0EF50D6C9D786
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0585461 – 184Missing in isoform d. Add BLAST184
Alternative sequenceiVSP_05854799 – 100Missing in isoform a and isoform c. 2
Alternative sequenceiVSP_058548180 – 230Missing in isoform c. Add BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF473217 mRNA Translation: ABQ42569.1
EF473218 mRNA Translation: ABQ42570.1
BX284604 Genomic DNA Translation: CAA21701.1
BX284604 Genomic DNA Translation: CAC70120.1
BX284604 Genomic DNA Translation: CAM82814.1
BX284604 Genomic DNA Translation: CBL43465.1

Protein sequence database of the Protein Information Resource

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PIRi
T27189

NCBI Reference Sequences

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RefSeqi
NP_001122818.1, NM_001129346.1 [G5EET6-3]
NP_001255652.1, NM_001268723.1 [G5EET6-4]
NP_502416.1, NM_070015.4 [G5EET6-1]
NP_502417.1, NM_070016.3 [G5EET6-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y55D9A.1a; Y55D9A.1a; WBGene00013223 [G5EET6-2]
Y55D9A.1b; Y55D9A.1b; WBGene00013223 [G5EET6-1]
Y55D9A.1c; Y55D9A.1c; WBGene00013223 [G5EET6-3]
Y55D9A.1d; Y55D9A.1d; WBGene00013223 [G5EET6-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
178217

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y55D9A.1

UCSC genome browser

More...
UCSCi
Y55D9A.1b c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF473217 mRNA Translation: ABQ42569.1
EF473218 mRNA Translation: ABQ42570.1
BX284604 Genomic DNA Translation: CAA21701.1
BX284604 Genomic DNA Translation: CAC70120.1
BX284604 Genomic DNA Translation: CAM82814.1
BX284604 Genomic DNA Translation: CBL43465.1
PIRiT27189
RefSeqiNP_001122818.1, NM_001129346.1 [G5EET6-3]
NP_001255652.1, NM_001268723.1 [G5EET6-4]
NP_502416.1, NM_070015.4 [G5EET6-1]
NP_502417.1, NM_070016.3 [G5EET6-2]

3D structure databases

SMRiG5EET6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y55D9A.1b

Proteomic databases

PaxDbiG5EET6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY55D9A.1a; Y55D9A.1a; WBGene00013223 [G5EET6-2]
Y55D9A.1b; Y55D9A.1b; WBGene00013223 [G5EET6-1]
Y55D9A.1c; Y55D9A.1c; WBGene00013223 [G5EET6-3]
Y55D9A.1d; Y55D9A.1d; WBGene00013223 [G5EET6-4]
GeneIDi178217
KEGGicel:CELE_Y55D9A.1
UCSCiY55D9A.1b c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178217
WormBaseiY55D9A.1a ; CE19234 ; WBGene00013223 ; efa-6
Y55D9A.1b ; CE29066 ; WBGene00013223 ; efa-6
Y55D9A.1c ; CE40826 ; WBGene00013223 ; efa-6
Y55D9A.1d ; CE44770 ; WBGene00013223 ; efa-6

Phylogenomic databases

eggNOGiKOG0932 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000155061
HOGENOMiHOG000254799
InParanoidiG5EET6
KOiK12494
OMAiEWCEKIN
OrthoDBi532213at2759
PhylomeDBiG5EET6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EET6

Gene expression databases

BgeeiWBGene00013223 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF15410 PH_9, 1 hit
PF01369 Sec7, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFA6_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EET6
Secondary accession number(s): D4YWC5, G5EBY7, Q9XWG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: December 14, 2011
Last modified: May 8, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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