Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 91 (29 Sep 2021)
Sequence version 1 (14 Dec 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Cysteine and histidine-rich domain-containing protein 1

Gene

chp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates centrosome duplication (By similarity).

Controls the secretion of the tyrosine kinase receptor let-23/EGFR from the endoplasmic reticulum and is required for the localization of let-23/EGFR to the plasma membrane of vulval precursor cells (PubMed:32053105).

It thus plays a role in positively regulating let/EGFR signaling, and anchor cell and vulval precursor cell alignment (PubMed:32053105).

Plays a role in vulval development and morphogenesis (PubMed:10571178, PubMed:32053105).

By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi9Zinc 1PROSITE-ProRule annotation1
Metal bindingi14Zinc 1PROSITE-ProRule annotation1
Metal bindingi28Zinc 1PROSITE-ProRule annotation1
Metal bindingi31Zinc 2PROSITE-ProRule annotation1
Metal bindingi46Zinc 2PROSITE-ProRule annotation1
Metal bindingi47Zinc 2PROSITE-ProRule annotation1
Metal bindingi63Zinc 2PROSITE-ProRule annotation1
Metal bindingi68Zinc 1PROSITE-ProRule annotation1
Metal bindingi152Zinc 3PROSITE-ProRule annotation1
Metal bindingi157Zinc 3PROSITE-ProRule annotation1
Metal bindingi170Zinc 3PROSITE-ProRule annotation1
Metal bindingi173Zinc 4PROSITE-ProRule annotation1
Metal bindingi188Zinc 4PROSITE-ProRule annotation1
Metal bindingi189Zinc 4PROSITE-ProRule annotation1
Metal bindingi205Zinc 4PROSITE-ProRule annotation1
Metal bindingi210Zinc 3PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • zinc ion binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine and histidine-rich domain-containing protein 1Curated
Alternative name(s):
CHORD domain-containing protein 1Curated
Short name:
CHORD-containing protein 1Curated
Protein CHORDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chp-1Imported
Synonyms:chpImported
ORF Names:Y110A7A.13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y110A7A.13 ; CE23244 ; WBGene00000502 ; chp-1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in reduced fertility and in high levels of embryonic lethality with none of the unhatched embryos reaching the comma stage of development (PubMed:10571178). Among the 40% of embryos that hatch, 98% reach adulthood, but have a reduced brood size, and the remaining 2% do not survive beyond the L1 larval stage (PubMed:10571178). Surviving adults have defects in vulval development, whereby 3-5% have a protruding vulva (Pvl) phenotype and 1% have a multivulva (Mvl) phenotype (PubMed:10571178). Occasionally, some adults have one missing gonadal arm, but many adults have defects in the organization of the proximal arm of the gonad, which are filled with smaller cells instead of full sized oocytes (PubMed:10571178). RNAi-mediated knockdown results in reduced plasma membrane localization and increased intracellular accumulation of let-23 in vulval precursor cells P6.p and their descendants (PubMed:32053105). RNAi-mediated knockdown does not affect the membrane localization of lin-12, lin-18 or pat-3 (PubMed:32053105). RNAi-mediated knockdown in vulval precursor cells results in the intracellular accumulation of let-23 in 31% of cases (PubMed:32053105).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004504411 – 321Cysteine and histidine-rich domain-containing protein 1Add BLAST321

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
G5EEI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000502, Expressed in germ line (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5EEI8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.Y110A7A.13

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EEI8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 68CHORD 1PROSITE-ProRule annotationAdd BLAST60
Domaini152 – 210CHORD 2PROSITE-ProRule annotationAdd BLAST59
Domaini218 – 308CSPROSITE-ProRule annotationAdd BLAST91

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1667, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159429

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_040079_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQKGCVY

Database of Orthologous Groups

More...
OrthoDBi
1163528at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EEI8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007051, CHORD_dom
IPR007052, CS_dom
IPR008978, HSP20-like_chaperone

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04968, CHORD, 2 hits
PF04969, CS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764, SSF49764, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51401, CHORD, 2 hits
PS51203, CS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EEI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDESKLQCY HKGCGLLFDP KENDNEACTY HPGGPYFHDA YKIWTCCDKK
60 70 80 90 100
STDFGTWMNY KGCTRGKHSN EKPVDIVKVA AVKEIRPEKE EDVIVWKGLN
110 120 130 140 150
KSGKLDSKDA TKRIEQNLNV EVTPGATAAI EKKLKEISEA AQSADIQIGA
160 170 180 190 200
PCRNNGCSTE FDGSKNKENC QHHPGAAIFH EGMKYWSCCN KKTSNFGAFL
210 220 230 240 250
EQVGCTSGEH KFRNNEIVSK FREDWFSSNG FVTINVYCRG ALPETANIVS
260 270 280 290 300
DGHTVRVSMK HGFGNASVDL DYDLWDEVIP EESRVVIGER KVEISLKQKH
310 320
GTGWPRLKFD PELDAKNDEE A
Length:321
Mass (Da):36,007
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FF2228055BE2FBE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF192264 mRNA Translation: AAF18435.1
BX284601 Genomic DNA Translation: CCD66204.1

NCBI Reference Sequences

More...
RefSeqi
NP_491519.1, NM_059118.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y110A7A.13.1; Y110A7A.13.1; WBGene00000502
Y110A7A.13.2; Y110A7A.13.2; WBGene00000502

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y110A7A.13

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192264 mRNA Translation: AAF18435.1
BX284601 Genomic DNA Translation: CCD66204.1
RefSeqiNP_491519.1, NM_059118.4

3D structure databases

SMRiG5EEI8
ModBaseiSearch...

Protein-protein interaction databases

IntActiG5EEI8, 1 interactor
STRINGi6239.Y110A7A.13

Proteomic databases

PeptideAtlasiG5EEI8

Genome annotation databases

EnsemblMetazoaiY110A7A.13.1; Y110A7A.13.1; WBGene00000502
Y110A7A.13.2; Y110A7A.13.2; WBGene00000502
GeneIDi172138
KEGGicel:CELE_Y110A7A.13

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172138
WormBaseiY110A7A.13 ; CE23244 ; WBGene00000502 ; chp-1

Phylogenomic databases

eggNOGiKOG1667, Eukaryota
GeneTreeiENSGT00940000159429
HOGENOMiCLU_040079_0_0_1
OMAiAQKGCVY
OrthoDBi1163528at2759
PhylomeDBiG5EEI8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EEI8

Gene expression databases

BgeeiWBGene00000502, Expressed in germ line (C elegans) and 5 other tissues

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007051, CHORD_dom
IPR007052, CS_dom
IPR008978, HSP20-like_chaperone
PfamiView protein in Pfam
PF04968, CHORD, 2 hits
PF04969, CS, 1 hit
SUPFAMiSSF49764, SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51401, CHORD, 2 hits
PS51203, CS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHRD1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EEI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 12, 2020
Last sequence update: December 14, 2011
Last modified: September 29, 2021
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again