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Entry version 85 (02 Dec 2020)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Piwi domain-containing protein

Gene

rde-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-203927, MicroRNA (miRNA) biogenesis
R-CEL-426486, Small interfering RNA (siRNA) biogenesis
R-CEL-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Piwi domain-containing proteinImported
Submitted name:
RNA interference promoting factor RDE-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rde-1Imported
ORF Names:CELE_K08H10.7Imported, K08H10.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
K08H10.7 ; CE28243 ; WBGene00004323 ; rde-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004323, Expressed in germ line (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60528N

Protein interaction database and analysis system

More...
IntActi
G5EEH0, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.K08H10.7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini619 – 985PiwiInterPro annotationAdd BLAST367

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1041, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012682_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNMIVTQ

Database of Orthologous Groups

More...
OrthoDBi
159407at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02171, Piwi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00950, Piwi, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50822, PIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EEH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSNFPELEK GFYRHSLDPE MKWLARPTGK CDGKFYEKKV LLLVNWFKFS
60 70 80 90 100
SKIYDREYYE YEVKMTKEVL NRKPGKPFPK KTEIPIPDRA KLFWQHLRHE
110 120 130 140 150
KKQTDFILED YVFDEKDTVY SVCRLNTVTS KMLVSEKVVK KDSEKKDEKD
160 170 180 190 200
LEKKILYTMI LTYRKKFHLN FSRENPEKDE EANRSYKFLK NVMTQKVRYA
210 220 230 240 250
PFVNEEIKVQ FAKNFVYDNN SILRVPESFH DPNRFEQSLE VAPRIEAWFG
260 270 280 290 300
IYIGIKELFD GEPVLNFAIV DKLFYNAPKM SLLDYLLLIV DPQSCNDDVR
310 320 330 340 350
KDLKTKLMAG KMTIRQAARP RIRQLLENLK LKCAEVWDNE MSRLTERHLT
360 370 380 390 400
FLDLCEENSL VYKVTGKSDR GRNAKKYDTT LFKIYEENKK FIEFPHLPLV
410 420 430 440 450
KVKSGAKEYA VPMEHLEVHE KPQRYKNRID LVMQDKFLKR ATRKPHDYKE
460 470 480 490 500
NTLKMLKELD FSSEELNFVE RFGLCSKLQM IECPGKVLKE PMLVNSVNEQ
510 520 530 540 550
IKMTPVIRGF QEKQLNVVPE KELCCAVFVV NETAGNPCLE ENDVVKFYTE
560 570 580 590 600
LIGGCKFRGI RIGANENRGA QSIMYDATKN EYAFYKNCTL NTGIGRFEIA
610 620 630 640 650
ATEAKNMFER LPDKEQKVLM FIIISKRQLN AYGFVKHYCD HTIGVANQHI
660 670 680 690 700
TSETVTKALA SLRHEKGSKR IFYQIALKIN AKLGGINQEL DWSEIAEISP
710 720 730 740 750
EEKERRKTMP LTMYVGIDVT HPTSYSGIDY SIAAVVASIN PGGTIYRNMI
760 770 780 790 800
VTQEECRPGE RAVAHGRERT DILEAKFVKL LREFAENNDN RAPAHIVVYR
810 820 830 840 850
DGVSDSEMLR VSHDELRSLK SEVKQFMSER DGEDPEPKYT FIVIQKRHNT
860 870 880 890 900
RLLRRMEKDK PVVNKDLTPA ETDVAVAAVK QWEEDMKESK ETGIVNPSSG
910 920 930 940 950
TTVDKLIVSK YKFDFFLASH HGVLGTSRPG HYTVMYDDKG MSQDEVYKMT
960 970 980 990 1000
YGLAFLSARC RKPISLPVPV HYAHLSCEKA KELYRTYKEH YIGDYAQPRT
1010 1020
RHEMEHFLQT NVKYPGMSFA
Length:1,020
Mass (Da):118,804
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E2F1A2EFC43A670
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF180730 mRNA Translation: AAF06159.1
BX284605 Genomic DNA Translation: CAB05546.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T23510

NCBI Reference Sequences

More...
RefSeqi
NP_741611.1, NM_171525.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K08H10.7.1; K08H10.7.1; WBGene00004323

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K08H10.7

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180730 mRNA Translation: AAF06159.1
BX284605 Genomic DNA Translation: CAB05546.2
PIRiT23510
RefSeqiNP_741611.1, NM_171525.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-60528N
IntActiG5EEH0, 3 interactors
STRINGi6239.K08H10.7

Genome annotation databases

EnsemblMetazoaiK08H10.7.1; K08H10.7.1; WBGene00004323
GeneIDi179393
KEGGicel:CELE_K08H10.7

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179393
WormBaseiK08H10.7 ; CE28243 ; WBGene00004323 ; rde-1

Phylogenomic databases

eggNOGiKOG1041, Eukaryota
HOGENOMiCLU_012682_0_0_1
OMAiRNMIVTQ
OrthoDBi159407at2759

Enzyme and pathway databases

ReactomeiR-CEL-203927, MicroRNA (miRNA) biogenesis
R-CEL-426486, Small interfering RNA (siRNA) biogenesis
R-CEL-5578749, Transcriptional regulation by small RNAs

Gene expression databases

BgeeiWBGene00004323, Expressed in germ line (C elegans) and 5 other tissues

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF02171, Piwi, 1 hit
SMARTiView protein in SMART
SM00950, Piwi, 1 hit
SUPFAMiSSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50822, PIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EEH0_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EEH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: December 2, 2020
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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